Young Adult and Midlife Transitions in Physical Activity and Sedentary Behavior with Heart Failure Risk and Progression: Coronary Artery Risk Development in Young Adults (CARDIA)

年轻人和中年体力活动和久坐行为的转变与心力衰竭风险和进展：年轻人冠状动脉风险发展（CARDIA）

• 批准号: 10687120
• 负责人: Kelley Pettee Gabriel
• 金额: $ 93.88万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-08-01 至 2024-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10687120
• 关键词: Accelerometer; Address; Adult; Aerobic; Age; Aging; Agreement; Ancillary Study; Attenuated; Behavioral; Biological; Biological Markers; Black Populations; Blood specimen; Brain natriuretic peptide; Cardiac; Caring; Classification; Clinical; Clinical Trials Design; Complement; Coronary Artery Risk Development in Young Adults Study; Coronary heart disease; Data; Disease; Disparity; Dose; EFRAC; Early Intervention; Elderly; Eligibility Determination; Equation; Event; Exercise Test; Financial Hardship; Functional disorder; Future; Goals; Guidelines; Health; Health Benefit; Healthcare Systems; Heart failure; High Prevalence; Hour; Hypertension; Individual; Intervention; Leisures; Literature; Maintenance; Measures; N-terminal; Nature; Non-Insulin-Dependent Diabetes Mellitus; Older Population; Outcome; Oxygen; Participant; Pharmacotherapy; Phenotype; Physical activity; Population; Prevalence; Prevention; Prevention approach; Prevention strategy; Progressive Disease; Public Health; Race; Race Relations; Reporting; Research; Risk; Testing; Time; Troponin T; Walking; Woman; Work; behavior change; black men; cardiorespiratory fitness; chronotropic; clinical practice; clinical risk; cohort; comorbidity; emerging adult; improved; innovation; lifetime risk; light intensity; meter; middle age; novel; outcome prediction; pre-clinical; preservation; prevent; programs; public health relevance; racial disparity; response; sedentary; sedentary lifestyle; sex; uptake; vigorous intensity; young adult

ABSTRACT Heart failure prevalence is increasing in the U.S., particularly among blacks and older adults. Heart failure is a progressive disease defined by stages, and onset of asymptomatic, preclinical heart failure is often evident decades before symptomatic, clinical disease. This provides an opportunity to discover novel targets for intervention during preclinical stages to prevent or attenuate progression to clinical heart failure stages. This early prevention approach is critical since, once an individual advances to the next stage, regression is unlikely. Reported moderate to vigorous intensity physical activity (MVPA) and cardiorespiratory fitness (CRF) are independently related to a reduced risk of lifetime, clinical heart failure; a relation that has been primarily studied in midlife or older adults. Nothing is known about the relations of light intensity physical activity (LPA) or sedentary behaviors (SED) with heart failure. This focus on event-driven endpoints discounts the progressive nature of heart failure and biases the field against discovery of novel targets for improving more proximal outcomes that are predictive of future clinical disease, including N-terminal pro-brain natriuretic peptide (NT-proBNP), high sensitivity cardiac Troponin T (hscTnT), peak oxygen uptake (peak VO2), and heart failure stage classification. Evidence from CARDIA demonstrates an increased prevalence of preclinical heart failure, and progression to more severe heart failure stages over 25-years defining young adulthood to midlife. This has occurred in parallel with declines in reported MVPA and CRF over these 25-years, and replacement of active time for sedentary time (based on accelerometry) during the first 10-years of midlife. Given that these biomarkers are not currently available in CARDIA, the impacts of these exposures have not been tested in this cohort, or in other studies. To address this need, we propose the CARDIA Activity and Heart Failure (ACT-HF) Study, a four-year ancillary study to the Year 35 core exam (2020-21; cohort ages 53-65 years). Participants will be all those who attend the core exam, who meet eligibility criteria, and agree to participate (estimated n≥2,431). To complement 35-years of extant data, CARDIA ACT-HF measures include: (1) third accelerometry measures to fully characterize midlife, (2) first measures of NT-proBNP and hscTnT in CARDIA (at Years 20, 30 & 35 via stored blood samples), and (3) a final maximal graded exercise test (GXT) test for measured or estimated peak VO2. The validity of the 400-meter walk test, as a possible replacement for the maximal GXT in future exams, will be tested. We aim to examine the: (1) independent and simultaneous longitudinal relations of 20-year changes in a) reported MVPA and b) CRF from early adulthood to midlife with 15-year changes in heart failure biomarkers collected across midlife; (2) independent and simultaneous longitudinal relations of accelerometer-based a) MVPA, b) LPA, and c) SED changes with heart failure biomarkers across midlife; and (3) bidirectional relations of a) accelerometer-based MVPA, LPA, and SED and b) CRF with heart failure stages across midlife. Interactions of these relations by race and sex will be tested in all study aims.

摘要

项目成果

Blood-Based Fingerprint of Cardiorespiratory Fitness and Long-Term Health Outcomes in Young Adulthood.

呼吸疾病适应性的血液指纹和成年后的长期健康结果。

• DOI: 10.1161/jaha.122.026670
• 发表时间: 2022-09-20
• 期刊: JOURNAL OF THE AMERICAN HEART ASSOCIATION
• 影响因子: 5.4
• 作者: Shah, Ravi, V;Miller, Patricia;Colangelo, Laura A.;Chernofsky, Ariel;Houstis, Nicholas E.;Malhotra, Rajeev;Velagaleti, Raghava S.;Jacobs, David R., Jr.;Gabriel, Kelley Pettee;Reis, Jared P.;Lloyd-Jones, Donald M.;Clish, Clary B.;Larson, Martin G.;Vasan, Ramachandran S.;Murthy, Venkatesh L.;Lewis, Gregory D.;Nayor, Matthew
• 通讯作者: Nayor, Matthew

Associations of Physical Activity and Lactation Duration With Cardiometabolic Risk Factors: The CARDIA Study.

体力活动和哺乳时间与心脏代谢危险因素的关联：CARDIA 研究。

• DOI: 10.1016/j.jacadv.2023.100378
• 发表时间: 2023
• 期刊: JACC. Advances
• 作者: Lane,Abbi;Whitaker,KaraM;Tahir,Muna;BaroneGibbs,Bethany;Catov,Janet;Carnethon,Mercedes;Gunderson,EricaP
• 通讯作者: Gunderson,EricaP

Factors Associated with Age-Related Declines in Cardiorespiratory Fitness from Early Adulthood Through Midlife: CARDIA.

• DOI: 10.1249/mss.0000000000002893
• 发表时间: 2022-07-01
• 期刊: Medicine and science in sports and exercise
• 影响因子: 4.1

Thirteen-Year Associations of Occupational and Leisure-Time Physical Activity with Cardiorespiratory Fitness in CARDIA.

CARDIA 职业和休闲时间身体活动与心肺健康的十三年协会。

• DOI: 10.1249/mss.0000000000003237
• 发表时间: 2023
• 期刊: Medicine and science in sports and exercise
• 影响因子: 4.1
• 作者: Quinn,TylerD;Lane,Abbi;PetteeGabriel,Kelley;Sternfeld,Barbara;JacobsJr,DavidR;Smith,Peter;BaroneGibbs,Bethany
• 通讯作者: BaroneGibbs,Bethany