Markerless Tracking of 3D Posture to Reveal the Sensory Origins of Body Schema
3D 姿势无标记跟踪揭示身体图式的感官起源
基本信息
- 批准号:10410450
- 负责人:
- 金额:$ 6.98万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-06-01 至 2023-05-31
- 项目状态:已结题
- 来源:
- 关键词:3-DimensionalAddressAffectAmputationAnatomyAnimalsAreaAwarenessBehaviorBehavioralBody partBrainClinicalCodeCognitiveCollaborationsCommunitiesComputer AnalysisComputer Vision SystemsData AnalysesDeafferentation procedureDiseaseEducational workshopElectrophysiology (science)ElementsEngineeringEnvironmentExcisionExperimental ModelsFacultyFeedbackGoalsHeadHealthHumanIndividualInterventionKnowledgeLabelLearningLimb ProsthesisLimb structureLocomotionMachine LearningMaintenanceMedicalMentorshipMethodologyMethodsModelingMonitorMotorMovementMusNeurobiologyNeuronsOperative Surgical ProceduresParietal LobePositioning AttributePostureProcessProxyReportingResearchResearch TrainingSelf PerceptionSensorySomatosensory CortexSpecialistSpeedStrokeSystemTactileTalentsTechnical ExpertiseTechniquesTechnologyTestingTouch sensationTrainingUniversitiesUpdateVertebral columnbasebrain machine interfacecareercomputational neuroscienceconvolutional neural networkdeep learningdesignexperimental studymeetingsmotor controlneural circuitneural correlateneuromechanismnovelnovel strategiesoptogeneticsprofessorrelating to nervous systemresearch to practicesensory inputskillssocial cognitionsomatosensorystroke recoverysymposiumtenure tracktool
项目摘要
The goal of this proposed research is to reveal the sensory origins underlying the body schema
representation. Body schema is the brain's internal model of the body's spatial configuration. This internal
representation is critical for sensorimotor processing, movement control, and self-awareness, and is
continuously updated during movement. Body schema representations are disrupted when somatosensory input
is lost. The first step toward discover the neural correlates of body schema is to uncover neural mechanisms that
generate body posture representation. We hypothesize that sensory inputs from primary somatosensory cortex
(S1) and secondary somatosensory cortex (S2) to the posterior parietal cortex (PPC) are transformed to
construct a body posture representation.
To delineate the mechanisms underlying the neural coding of body posture, this project will utilize large-
scale monitoring, apply interventional tools, develop new data analysis tools, and integrate new approaches. Our
approach is to perform large-scale electrophysiological recording and novel markerless tracking of 3D posture
in freely moving mice. To track posture, the first aim is to adapt a markerless tracking pipeline comprised of a
deep 3D convolutional neural network to process high-speed videography of mouse behavior from multiple
cameras. The second aim is to perform large-scale recording of neurons in S1, S2, and PPC and use advanced
computational approaches to determine which postural features best explain the activity of neurons in these
cortical areas. Finally, the third aim is to use optogenetic and projection-specific manipulations to address the
causal impact of proprioceptive inputs from S1 and S2 on coding of posture in PPC. This research promises to
uncover how sensory inputs are involved in generating the body schema representation and guiding behavior.
Extensive training will be required to carry out this project and achieve my goal of earning a tenure-track
professor position. The rigorous methodological and intellectual environment in Dr. Fan Wang’s lab and the Duke
Neurobiology community will advance my conceptual knowledge and technical skills. I will implement deep
learning techniques through training and collaboration with specialists. I will learn new techniques by attending
Neuropixel and computational neuroscience courses. Finally, I will develop my professional skills by frequent
attendance of seminars, workshops, and meeting with a postdoctoral mentorship committee.
The proposed project will be conducted in the Department of Neurobiology at the Duke University Medical
Campus. This interdisciplinary community at Duke will bolster the research and training included in this
application through frequent interaction with talented and collaborative faculty, organization of seminars and
symposia, numerous opportunities to practice research talks and receive valuable feedback, formation of a
personalized postdoctoral mentorship committee, extensive career and professional training, and invaluable
support from the postdoctoral association.
这项研究的目的是揭示身体图式背后的感觉起源
表示。身体图式是大脑对身体空间配置的内部模型。这个内部
表征对于感觉运动处理、运动控制和自我意识至关重要,并且
运动过程中不断更新。当体感输入时,身体图式表示会被破坏
丢失了。发现身体图式的神经关联的第一步是揭示神经机制
生成身体姿势表示。我们假设来自初级体感皮层的感觉输入
(S1) 和次级体感皮层 (S2) 到后顶叶皮层 (PPC) 转化为
构建身体姿势表示。
为了描述身体姿势神经编码的机制,该项目将利用大
规模监测、应用干预工具、开发新的数据分析工具并整合新方法。我们的
方法是进行大规模电生理记录和新颖的 3D 姿势无标记跟踪
在自由活动的小鼠中。为了跟踪姿势,第一个目标是采用由
深度 3D 卷积神经网络处理多个小鼠行为的高速摄像
相机。第二个目标是对 S1、S2 和 PPC 中的神经元进行大规模记录,并使用先进的
计算方法来确定哪些姿势特征最能解释这些神经元的活动
皮质区域。最后,第三个目标是使用光遗传学和投影特异性操作来解决
S1 和 S2 的本体感受输入对 PPC 姿势编码的因果影响。这项研究有望
揭示感官输入如何参与生成身体图式表征和指导行为。
需要进行广泛的培训才能开展该项目并实现我获得终身教职的目标
教授职位。王帆博士实验室和杜克大学严谨的方法论和智力环境
神经生物学社区将提高我的概念知识和技术技能。我将深入贯彻落实
通过培训和与专家合作来学习技术。我将通过参加学习新技术
神经像素和计算神经科学课程。最后,我将通过频繁地培养我的专业技能
参加研讨会、讲习班以及与博士后指导委员会的会议。
拟议的项目将在杜克大学医学院神经生物学系进行
校园。杜克大学的这个跨学科社区将加强本项目中的研究和培训
通过与有才华和协作的教师的频繁互动、组织研讨会和
研讨会、大量实践研究演讲并获得宝贵反馈的机会、形成
个性化的博士后导师委员会、广泛的职业和专业培训以及宝贵的
博士后协会的支持。
项目成果
期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Geometric deep learning enables 3D kinematic profiling across species and environments.
- DOI:10.1038/s41592-021-01106-6
- 发表时间:2021-05
- 期刊:
- 影响因子:48
- 作者:Dunn TW;Marshall JD;Severson KS;Aldarondo DE;Hildebrand DGC;Chettih SN;Wang WL;Gellis AJ;Carlson DE;Aronov D;Freiwald WA;Wang F;Ölveczky BP
- 通讯作者:Ölveczky BP
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Kyle Scott Severson其他文献
Kyle Scott Severson的其他文献
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{{ truncateString('Kyle Scott Severson', 18)}}的其他基金
Markerless Tracking of 3D Posture to Reveal the Sensory Origins of Body Schema
3D 姿势无标记跟踪揭示身体图式的感官起源
- 批准号:
10216941 - 财政年份:2020
- 资助金额:
$ 6.98万 - 项目类别:
Markerless Tracking of 3D Posture to Reveal the Sensory Origins of Body Schema
3D 姿势无标记跟踪揭示身体图式的感官起源
- 批准号:
10326961 - 财政年份:2020
- 资助金额:
$ 6.98万 - 项目类别:
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