Development & Malleability from Childhood to Adulthood
发展
基本信息
- 批准号:10410479
- 负责人:
- 金额:$ 69.45万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2018
- 资助国家:美国
- 起止时间:2018-08-01 至 2024-05-31
- 项目状态:已结题
- 来源:
- 关键词:Academic achievementAdolescenceAdultAfrican AmericanAfrican American populationAgeAnxietyBaltimoreBehaviorBirthCharacteristicsChild RearingChildhoodCoercionCommunitiesCountryDNADataDependenceDevelopmentDiseaseDistalEconomically Deprived PopulationEpidemiologyEpigenetic ProcessFamilyFutureGeneticHabitsHousingIncomeIndependent LivingInsectaInterventionKnowledgeLeadLengthMarriageMeasuresMediationMediator of activation proteinModelingMoldsNatureNeighborhoodsOccupationsOutcomeParticipantPathogenicityPeer GroupPhenotypePopulationPrevention trialRandomizedRiotsRodentRoleSchoolsSexually Transmitted DiseasesStressSubstance abuse problemTelomeraseTimeVariantWagesWorkantisocial behaviorbasechild depressiondisorder riskelementary schoolemerging adultfallsfirst gradehigh risk sexual behaviormeetingspreventive interventionprospectivepsychiatric symptomracial discriminationsocialsoundsubstance useteachertelomereviolent crimeyoung adult
项目摘要
Abstract
The central purpose of the proposed study is to extend through ages 31-35 an examination of normal and
pathogenic development and the impact of two, universal, first grade, preventive interventions on the distal
targets of: antisocial behavior, substance abuse/dependence, psychiatric symptoms/disorders, high risk sexual
behavior, and successful adaptation to the relevant developmental demands of the educational, work, romantic
relationships, and family (both family of procreation and origin/orientation) social fields/contexts. This study
capitalizes on the scientific value of 1) a prospective, developmental epidemiological prevention trial involving a
population (N = 798) of urban, predominately African-American young adults, who began first grade in the fall
of 1993 in 9 elementary schools in predominantly low to lower middle-income Baltimore areas96. Participants
and teachers were randomly assigned to one of two universal, elementary school-based, preventive
interventions, or a control condition. Both interventions—the Family School Partnership (FSP) and Classroom-
Centered (CC)--targeted aggressive-coercive behavior and poor academic achievement as antecedents of the
distal outcomes elaborated above. Annual data on these outcomes and their hypothesized phenotypic
moderators and mediators, including participant, family, peer group, school, and neighborhood characteristics,
have been collected from 1st grade through age 26. DNA was obtained in early adulthood, which has allowed
examination of the interplay between genetic and phenotypic factors in explaining variation in developmental
and intervention outcomes. The proposed annual assessments will allow a more precise assessment of the
timing and sequencing of the interplay of phenotypic and genetic influences, including the interventions, on
successful adaptation to the relevant developmental challenges between the ages of 31-35. Similarly, we will
continue to study the role of phenotypic and genetic factors and the impact of the interventions on the
development and course of substance use/abuse/dependence, psychiatric symptoms/disorders, antisocial
behavior/disorder, and high risk sexual behavior through young adulthood. Finally, we will also assess
potential epigenetic effects in terms of change in telomere length and telomerase activity as a function of
accumulative stress over time and the interventions as moderators of the stress/telomere relationship. The
knowledge accrued over the course of the proposed assessments should serve to inform the nature, targets,
and timing of our future preventive intervention efforts.
摘要
这项研究的主要目的是对31-35岁的人进行一项正常和
病原体的发展和两种普遍的一级预防性干预措施对远端
目标:反社会行为,药物滥用/依赖,精神症状/障碍,高风险性行为
行为,并成功适应教育,工作,浪漫的相关发展需求
关系和家庭(包括生育家庭和出身/取向)社会领域/背景。本研究
利用以下科学价值:1)前瞻性、发展性流行病学预防试验,
城市人口(N = 798),主要是非洲裔美国年轻人,他们在秋季开始上一年级
1993年,在巴尔的摩主要是中低收入地区的9所小学中,参与者
教师们被随机分配到两个普遍的,以小学为基础的,预防性的
干预或控制条件。这两种干预措施----家庭学校伙伴关系和课堂----
中心(CC)-有针对性的攻击-胁迫行为和学业成绩差的前因,
上述远端结局。关于这些结果及其假设表型的年度数据
主持人和调解人,包括参与者,家庭,同龄人群体,学校和邻里特征,
都是从一年级到26岁收集的。DNA是在成年早期获得的,这使得
研究遗传和表型因素在解释发育变异中的相互作用
干预的结果。拟议的年度评估将有助于更准确地评估
表型和遗传影响相互作用的时间和顺序,包括干预措施,
成功适应31-35岁之间的相关发展挑战。同样,我们将
继续研究表型和遗传因素的作用以及干预措施对
物质使用/滥用/依赖的发展和过程,精神症状/障碍,反社会
行为/障碍,以及成年早期的高风险性行为。最后,我们还将评估
端粒长度和端粒酶活性的变化作为一个功能的潜在表观遗传效应
随着时间的推移累积的压力和干预作为压力/端粒关系的调节剂。的
在拟议的评估过程中积累的知识应有助于为评估的性质、目标
以及我们未来预防性干预工作的时间安排。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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NICHOLAS S IALONGO其他文献
NICHOLAS S IALONGO的其他文献
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{{ truncateString('NICHOLAS S IALONGO', 18)}}的其他基金
An Evaluation of an Integrated Approach to Prevention and Early Intervention
对预防和早期干预综合方法的评估
- 批准号:
9906869 - 财政年份:2016
- 资助金额:
$ 69.45万 - 项目类别:
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