Translational Post-doctoral Training in Neurodevelopment

项目摘要/摘要 这项名为“神经发育的转化性博士后培训(TPND)”的申请是对 申请额外五年的资助，以支持我们的院校培训补助金(T32)。TPND计划 波士顿儿童医院旨在为有前途的博士后研究人员(医学博士、博士或 博士/博士)，在从临床前考虑到的基本翻译主题方面进行高级培训 通过对患有一系列神经发育障碍的个人进行临床试验。大型 许多儿童、青少年和成年人受到早期开始的神经发育障碍的影响。 生命，并植根于异常的大脑回路。目前大多数可用的治疗方法对 神经发育障碍的病程。遗传学、神经科学和神经成像的最新进展 使我们对神经发育障碍的发病机制有了很大的了解。我们现在 有可能为这一领域的许多疾病开发基于机制的治疗方法，因此 迫切需要培训年轻的调查人员，他们将成为发起和执行方面的领导者 研究这些进步的界面，并最终改善受这些进步影响的个人的生活 精神错乱。TPND利用了翻译神经科学中心(TNC)的显著优势，即Fuss 波士顿神经精神疾病研究中心和认知神经科学实验室 儿童医院和哈佛医学院为学员提供从 通过临床试验参与神经发育障碍的临床前和认知神经科学实验室。 这一计划的一个关键前提是在翻译神经科学领域进行有效的研究培训 需要在翻译研究的各个领域拥有专业知识的两位导师 神经发育障碍和正在进行的计划，以支持受训者进行创新、高效率 影响翻译研究。17名教师导师将在2年内让实习生参加(3名新入职人员 每年)与翻译神经发育科学中反映核心的一系列最先进的方法 TNC计划的领域包括基础科学和翻译方法以及临床应用 参与神经发育障碍治疗试验的人群。这一研究经验将是 辅以教学和临床沉浸体验，旨在为学员提供技能 需要在这一关键和新兴领域成为成功的独立调查人员。最终，这项研究 经验将有可能产生新的治疗方法和洞察力，进而通过以下方式影响该领域 减少现在与神经发育相关的负担和护理成本以及社会成本 精神错乱。此外，该中心还将为有前途的年轻人开发跨学科研究培训模式。 这将对该领域产生革命性的影响。

Project Summary/Abstract This application, “Translational Postdoctoral Training in Neurodevelopment (TPND)” is a competing renewal to request five additional years of funding in support of our Institutional Training Grant (T32). The TPND Program at Boston Children's Hospital is designed to provide promising postdoctoral investigators (MD, PhD or MD/PhD) with advanced training in essential translational topics ranging from preclinical considerations through implementation of clinical trials for individuals with a range of neurodevelopmental disorders. Large numbers of children, adolescents, and adults are affected by neurodevelopmental disorders that begin early in life, and are rooted in aberrant brain circuitry. Most currently available treatments have had limited impact on the course of neurodevelopmental disorders. Recent advances in genetics, neuroscience, and neuroimaging have led to dramatic gains in our understanding of the pathogenesis of neurodevelopmental disorders. We now have the possibility of developing mechanism-based treatments for many disorders in this field, and thus there is an urgent need for training young investigators who will become the leaders in initiating and executing research at the interface of these advances and ultimately improving the lives of individuals affected with these disorders. TPND leverages the significant strengths of the Translational Neuroscience Center (TNC), the Fuss Center for Neuropsychiatric Disease Research, and the Laboratories of Cognitive Neuroscience at Boston Children's Hospital and Harvard Medical School to provide trainees with research experiences ranging from pre-clinical and cognitive neuroscience labs through clinical trial involvement in neurodevelopmental disorders. A key premise of this program is that effective research training in the field of translational neuroscience requires both mentors with expertise in areas across the continuum of translational research with neurodevelopmental disorders and ongoing programs to support the trainees to conduct innovative, high impact translational research. The 17 faculty mentors will involve trainees over a 2-year period (3 new entrants per year) with a range of state of the art methods in translational neurodevelopmental science that reflect core areas of the TNC program including basic science and translational methods as well as application to clinical populations in therapeutic trials for neurodevelopmental disorders. This research experience will be supplemented with both didactic and clinical immersion experiences designed to provide trainees with the skills needed to be successful independent investigators in this critical and emerging field. Ultimately this research experience will have the potential to yield new treatments and insight that in turn will impact the field by reducing the burdens and costs of care and costs to society that is now associated with neurodevelopmental disorders. In addition, the TPND will develop models of interdisciplinary research training for promising young scientists that will have a transformative impact on the field.