Translational Post-doctoral Training in Neurodevelopment

项目概要/摘要 这个应用程序，“神经发育（TPND）的翻译博士后培训”是一个竞争性的更新， 申请额外五年的资助，以支持我们的机构培训补助金（T32）。TPND计划 在波士顿儿童医院的目的是提供有前途的博士后研究人员（MD，博士或 医学博士/博士），在基本的翻译主题方面接受过高级培训，从临床前考虑 通过对患有一系列神经发育障碍的个体进行临床试验。大 许多儿童、青少年和成年人都受到开始于幼年的神经发育障碍的影响。 生命，并植根于异常的大脑回路。目前大多数可用的治疗方法对 神经发育障碍的过程。遗传学、神经科学和神经影像学的最新进展 在我们对神经发育障碍的发病机制的理解上取得了巨大的进展。我们现在 有可能为这一领域的许多疾病开发基于机制的治疗方法，因此， 迫切需要培训年轻的调查人员，他们将成为发起和执行 研究这些进步的界面，并最终改善受这些影响的个人的生活， 紊乱TPND利用转化神经科学中心（TNC）的显著优势，Fuss 波士顿神经精神疾病研究中心和认知神经科学实验室 儿童医院和哈佛医学院为学员提供研究经验， 临床前和认知神经科学实验室通过临床试验参与神经发育障碍。 该计划的一个关键前提是，在转化神经科学领域的有效研究培训 要求导师在翻译研究的连续性领域具有专业知识， 神经发育障碍和正在进行的计划，以支持学员进行创新，高 影响翻译研究。17名教师导师将在2年内培训学员（3名新学员 每年）与一系列最先进的方法，在转化神经发育科学，反映核心 TNC计划的领域包括基础科学和转化方法以及临床应用 神经发育障碍治疗试验中的人群。这一研究经验将是 辅以教学和临床沉浸式体验，旨在为学员提供技能 需要在这一关键和新兴领域成为成功的独立调查员。最终，这项研究 经验将有可能产生新的治疗方法和见解，反过来将影响该领域， 减少护理的负担和成本以及现在与神经发育相关的社会成本， 紊乱此外，TPND将为有前途的年轻人开发跨学科研究培训模式。 将对该领域产生变革性影响的科学家。

Project Summary/Abstract This application, “Translational Postdoctoral Training in Neurodevelopment (TPND)” is a competing renewal to request five additional years of funding in support of our Institutional Training Grant (T32). The TPND Program at Boston Children's Hospital is designed to provide promising postdoctoral investigators (MD, PhD or MD/PhD) with advanced training in essential translational topics ranging from preclinical considerations through implementation of clinical trials for individuals with a range of neurodevelopmental disorders. Large numbers of children, adolescents, and adults are affected by neurodevelopmental disorders that begin early in life, and are rooted in aberrant brain circuitry. Most currently available treatments have had limited impact on the course of neurodevelopmental disorders. Recent advances in genetics, neuroscience, and neuroimaging have led to dramatic gains in our understanding of the pathogenesis of neurodevelopmental disorders. We now have the possibility of developing mechanism-based treatments for many disorders in this field, and thus there is an urgent need for training young investigators who will become the leaders in initiating and executing research at the interface of these advances and ultimately improving the lives of individuals affected with these disorders. TPND leverages the significant strengths of the Translational Neuroscience Center (TNC), the Fuss Center for Neuropsychiatric Disease Research, and the Laboratories of Cognitive Neuroscience at Boston Children's Hospital and Harvard Medical School to provide trainees with research experiences ranging from pre-clinical and cognitive neuroscience labs through clinical trial involvement in neurodevelopmental disorders. A key premise of this program is that effective research training in the field of translational neuroscience requires both mentors with expertise in areas across the continuum of translational research with neurodevelopmental disorders and ongoing programs to support the trainees to conduct innovative, high impact translational research. The 17 faculty mentors will involve trainees over a 2-year period (3 new entrants per year) with a range of state of the art methods in translational neurodevelopmental science that reflect core areas of the TNC program including basic science and translational methods as well as application to clinical populations in therapeutic trials for neurodevelopmental disorders. This research experience will be supplemented with both didactic and clinical immersion experiences designed to provide trainees with the skills needed to be successful independent investigators in this critical and emerging field. Ultimately this research experience will have the potential to yield new treatments and insight that in turn will impact the field by reducing the burdens and costs of care and costs to society that is now associated with neurodevelopmental disorders. In addition, the TPND will develop models of interdisciplinary research training for promising young scientists that will have a transformative impact on the field.