Post-Doctoral Training in Joint Health

关节健康博士后培训

• 批准号: 10636625
• 负责人: D Rick Sumner
• 金额: $ 20.18万
• 依托单位: RUSH UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-06-01 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10636625
• 关键词: Health; Joints; post-doctoral training

We propose a post-doctoral training program in the multi-disciplinary area of musculoskeletal biology with the ultimate aim of developing future leaders in orthopedic- and rheumatology-related research. The program emphasizes research training in joint health, encompassing three major programmatic areas: osteoarthritis, total joint replacement and small molecule therapeutics. Dr. Rick Sumner (Cell & Molecular Medicine) will serve as the principal investigator with Dr. Anne-Marie Malfait (Internal Medicine-Rheumatology) and Dr. Markus Wimmer (Orthopedic Surgery) as the co-directors. We are requesting support for three post-doctoral fellows and three short-term trainees. Joint health is a theme that connects many departments at Rush, offering an environment and intellectual capital available to post-doctoral fellows that is unique in the nation. The multidisciplinary training that is offered integrates the research endeavors of scientists in basic science and clinical departments with clinician investigators, caregivers, and educators who specialize in musculoskeletal disease and joint health. The training themes for this grant represent the strengths of the preceptors who have been selected as mentors. Training will take place in the laboratories of 19 faculty in two basic science departments (Cell & Molecular Medicine and Physiology & Biophysics) and three clinical departments (Internal Medicine, Orthopedic Surgery and Pediatrics). There are currently 40 post-doctoral trainees in these departments, with 22 advised by preceptors on this application. These 19 faculty are principal investigators on grants totaling $8.4M in annual direct costs, including 31 R01 or R01 equivalent grants and 16 other grants. Our primary focus will be on training PhD post-doctoral fellows, but we will make every effort to recruit candidates with clinical training into our program. One means to encourage interest among clinical trainees is to provide meaningful introductory research experiences. Thus, we will include short-term trainees (medical students) in our program. There is a deep history of collaborative research among musculoskeletal researchers at Rush. We will take advantage of a very strong mentoring program and an active post-doctoral research society that has created a vibrant community for trainees. Our training plan focuses on the six competencies defined by the National Postdoctoral Association: Discipline-specific conceptual knowledge, Research skill development, Communication skills, Professionalism, Leadership and management skills, and Responsible conduct of research. Each mentee, his/her primary advisor and personalized mentoring committee will use individual development plans to guide their efforts with a focus on publishing and participating in national research meetings and submitting independent grants. We anticipate that trainees will be assigned to the T32 for two years with the expectation that support will transfer to individual awards (e.g., F32’s) or their preceptors’ grants. After completing our program, we expect the trainees to continue in science as independent, team-oriented, investigators.

我们提出了肌肉骨骼生物学多学科领域的博士后培训计划， 培养骨科和风湿病相关研究的未来领导者的最终目标。该计划 强调关节健康方面的研究培训，包括三个主要方案领域：骨关节炎， 全关节置换术和小分子疗法。里克·萨姆纳博士(细胞和分子医学)将 与Anne-Marie Malfait博士(内科-风湿病学)和Dr.Anne-Marie Malfait博士担任首席研究员。 马库斯·维默(整形外科)担任联合导演。我们请求为三位博士后提供支持 研究员和三名短期实习生。联合健康是拉什许多部门联系在一起的一个主题， 为博士后提供一个在全国独一无二的环境和智力资本。 所提供的多学科培训整合了基础科学科学家的研究努力。 和临床科室，有临床研究人员、护理人员和教育工作者，他们专门从事 肌肉骨骼疾病和关节健康。这笔赠款的培训主题代表了 被选为导师的导师。培训将在19名教员的实验室进行，分两个阶段进行 基础科学系(细胞与分子医学和生理与生物物理学)和三个临床 内科、整形外科和儿科。目前有40名博士后 这些部门的实习生，其中22人由教导员就此申请提供建议。这19名教职员工是校长 调查员每年直接费用共计840万美元，包括31笔R01或R01等值补助金和16笔 其他赠款。我们的主要重点将是培养博士后研究员，但我们将尽一切努力 招募经过临床培训的应聘者加入我们的计划。一种鼓励临床医生兴趣的方法 学员的目的是提供有意义的介绍性研究经验。因此，我们将包括短期受训人员。 (医科学生)在我们的项目中。肌肉骨骼之间的合作研究有着深厚的历史 拉什大学的研究人员。我们将利用非常强大的指导计划和活跃的博士后 研究协会为学员创造了一个充满活力的社区。我们的培训计划主要集中在六个方面 国家博士后协会定义的能力：特定学科的概念知识， 研究技能发展、沟通技能、专业精神、领导力和管理技能，以及 负责任的研究行为。每位学员、他/她的主要顾问和个性化辅导 委员会将使用个人发展计划来指导他们的努力，重点是出版和 参加国家研究会议并提交独立赠款。我们预计受训人员将 被分配到T32，为期两年，期望支持将转移到个人奖项(例如， F32‘S)或其导师的补助金。在完成我们的计划后，我们希望学员们继续从事科学研究 作为独立的、以团队为导向的调查人员。

项目成果

The Association of an Alpha-2 Adrenergic Receptor Agonist and Mortality in Patients With COVID-19.

• DOI: 10.3389/fmed.2021.797647
• 发表时间: 2021
• 期刊: Frontiers in medicine
• 影响因子: 3.9
• 作者: Hamilton JL;Vashi M;Kishen EB;Fogg LF;Wimmer MA;Balk RA
• 通讯作者: Balk RA

A MOVING CONTACT OF ARTICULATION ENHANCES THE BIOSYNTHETIC AND FUNCTIONAL RESPONSES OF ARTICULAR CARTILAGE.

关节的移动接触增强了关节软骨的生物合成和功能反应。

• DOI: 10.1016/j.biotri.2021.100180
• 发表时间: 2021
• 期刊: Biotribology (Oxford)
• 作者: Shekhawat,VivekK;Hamilton,JohnL;Pacione,CarolA;Schmid,ThomasM;Wimmer,MarkusA
• 通讯作者: Wimmer,MarkusA

The gut microbiota may be a novel pathogenic mechanism in loosening of orthopedic implants in rats.

• DOI: 10.1096/fj.202001364r
• 发表时间: 2020-11
• 期刊: FASEB journal : official publication of the Federation of American Societies for Experimental Biology
• 作者: Moran MM;Wilson BM;Li J;Engen PA;Naqib A;Green SJ;Virdi AS;Plaas A;Forsyth CB;Keshavarzian A;Sumner DR
• 通讯作者: Sumner DR

Therapeutic assessment of N-formyl-methionyl-leucyl-phenylalanine (fMLP) in reducing periprosthetic joint infection.

• DOI: 10.22203/ecm.v042a09
• 发表时间: 2021-08-26
• 期刊: European cells & materials
• 影响因子: 3.1
• 作者: Hamilton JL;Mohamed MF;Witt BR;Wimmer MA;Shafikhani SH
• 通讯作者: Shafikhani SH

Correlating Spatial Ability With Anatomy Assessment Performance: A Meta-Analysis.

• DOI: 10.1002/ase.2029
• 发表时间: 2021-05
• 期刊: ANATOMICAL SCIENCES EDUCATION
• 影响因子: 7.3
• 作者: Roach, Victoria A.;Mi, Misa;Mussell, Jason;Van Nuland, Sonya E.;Lufler, Rebecca S.;DeVeau, Kathryn M.;Dunham, Stacey M.;Husmann, Polly;Herriott, Hannah L.;Edwards, Danielle N.;Doubleday, Alison F.;Wilson, Brittany M.;Wilson, Adam B.
• 通讯作者: Wilson, Adam B.