Post-Doctoral Training in Joint Health

关节健康博士后培训

• 批准号: 10451818
• 负责人: D Rick Sumner
• 金额: $ 25.16万
• 依托单位: RUSH UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-06-01 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10451818
• 关键词: Health; Joints; post-doctoral training

We propose a post-doctoral training program in the multi-disciplinary area of musculoskeletal biology with the ultimate aim of developing future leaders in orthopedic- and rheumatology-related research. The program emphasizes research training in joint health, encompassing three major programmatic areas: osteoarthritis, total joint replacement and small molecule therapeutics. Dr. Rick Sumner (Cell & Molecular Medicine) will serve as the principal investigator with Dr. Anne-Marie Malfait (Internal Medicine-Rheumatology) and Dr. Markus Wimmer (Orthopedic Surgery) as the co-directors. We are requesting support for three post-doctoral fellows and three short-term trainees. Joint health is a theme that connects many departments at Rush, offering an environment and intellectual capital available to post-doctoral fellows that is unique in the nation. The multidisciplinary training that is offered integrates the research endeavors of scientists in basic science and clinical departments with clinician investigators, caregivers, and educators who specialize in musculoskeletal disease and joint health. The training themes for this grant represent the strengths of the preceptors who have been selected as mentors. Training will take place in the laboratories of 19 faculty in two basic science departments (Cell & Molecular Medicine and Physiology & Biophysics) and three clinical departments (Internal Medicine, Orthopedic Surgery and Pediatrics). There are currently 40 post-doctoral trainees in these departments, with 22 advised by preceptors on this application. These 19 faculty are principal investigators on grants totaling $8.4M in annual direct costs, including 31 R01 or R01 equivalent grants and 16 other grants. Our primary focus will be on training PhD post-doctoral fellows, but we will make every effort to recruit candidates with clinical training into our program. One means to encourage interest among clinical trainees is to provide meaningful introductory research experiences. Thus, we will include short-term trainees (medical students) in our program. There is a deep history of collaborative research among musculoskeletal researchers at Rush. We will take advantage of a very strong mentoring program and an active post-doctoral research society that has created a vibrant community for trainees. Our training plan focuses on the six competencies defined by the National Postdoctoral Association: Discipline-specific conceptual knowledge, Research skill development, Communication skills, Professionalism, Leadership and management skills, and Responsible conduct of research. Each mentee, his/her primary advisor and personalized mentoring committee will use individual development plans to guide their efforts with a focus on publishing and participating in national research meetings and submitting independent grants. We anticipate that trainees will be assigned to the T32 for two years with the expectation that support will transfer to individual awards (e.g., F32’s) or their preceptors’ grants. After completing our program, we expect the trainees to continue in science as independent, team-oriented, investigators.

我们提出了肌肉骨骼生物学多学科领域的博士后培训计划 最终目标是培养骨科和风湿病学相关研究的未来领导者。该计划 强调关节健康方面的研究培训，涵盖三个主要规划领域：骨关节炎、 全关节置换术和小分子疗法。 Rick Sumner 博士（细胞与分子医学）将 与 Anne-Marie Malfait 博士（内科-风湿病学）和 Dr. Anne-Marie Malfait 博士一起担任首席研究员。 Markus Wimmer（骨科）担任联合主任。我们正在请求支持三名博士后 研究员和三名短期实习生。关节健康是连接 Rush 多个部门的一个主题， 为博士后研究员提供全国独一无二的环境和智力资本。 提供的多学科培训整合了基础科学科学家的研究成果 以及临床部门，其中包括专门从事以下领域的临床研究人员、护理人员和教育工作者 肌肉骨骼疾病和关节健康。这笔赠款的培训主题代表了该机构的优势 被选为导师的导师。培训将在两个地区 19 名教员的实验室进行 基础科学系（细胞与分子医学以及生理学与生物物理学）和三个临床系 科室（内科、骨科和儿科）。现有博士后40人 这些部门的受训人员中，有 22 名受训人员就本申请提供建议。这19位教授是校长 研究人员每年直接费用总计 840 万美元的补助金，包括 31 项 R01 或 R01 同等补助金和 16 项 其他补助金。我们的首要重点是培养博士、博士后研究员，但我们将尽一切努力 招募接受过临床培训的候选人加入我们的计划。一种激发临床兴趣的方法 受训者的目的是提供有意义的介绍性研究经验。因此，我们将包括短期实习生 （医学生）在我们的项目中。肌肉骨骼领域的合作研究有着悠久的历史 拉什的研究人员。我们将利用非常强大的指导计划和活跃的博士后 研究协会为学员创建了一个充满活力的社区。我们的培训计划重点关注六大方面 国家博士后协会定义的能力：特定学科的概念知识， 研究技能发展、沟通技能、专业精神、领导力和管理技能，以及 负责任地进行研究。每个受训者、他/她的主要顾问和个性化指导 委员会将使用个人发展计划来指导他们的工作，重点是出版和 参加国家研究会议并提交独立资助。我们预计学员将 被分配到 T32 两年，期望支持将转移到个人奖项（例如， F32）或他们的导师的资助。完成我们的计划后，我们希望学员继续从事科学工作 作为独立的、以团队为导向的调查员。