Genetic dissection of dementia
痴呆症的基因剖析
基本信息
- 批准号:10412678
- 负责人:
- 金额:$ 15.3万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-05-13 至 2026-04-30
- 项目状态:未结题
- 来源:
- 关键词:AcetylcholineAddressAffectAgeAllelesAlzheimer&aposs DiseaseAlzheimer&aposs disease related dementiaAmericanAmyloidAnimal ModelBiomedical ResearchCandidate Disease GeneCaregiversChronic DiseaseCommunitiesConsumptionDNA Sequence AlterationDeletion MutationDementiaDevelopmentDiseaseDissectionDrosophila genusDrosophila melanogasterEconomic BurdenElderlyEnzymesEtiologyGene ExpressionGene MutationGenesGeneticGenetic CrossesGenetic ScreeningGoalsHispanic PopulationsInsertion MutationIntercistronic RegionIntronsKnowledgeLinkMammalsMeasuresMemoryMemory LossMutationNerve DegenerationNeurosciences ResearchOxidative StressPathogenicityPoint MutationPrevalencePreventionProcessProgressive DiseaseRNA InterferenceResearchResearch TrainingRestRodent ModelRoleSleep DeprivationSocietiesStudentsSymptomsSynapsesTauopathiesTestingTherapeuticTimeTraining and EducationTransgenic OrganismsX Chromosomeage relatedbiological researchcaucasian Americancombatconditioningcostcost effectivedopaminergic neuronendophenotypeexecutive functionflygene discoverygene functiongenetic risk factorgenome wide association studygenomic locushealth economicshuman old age (65+)innovationinsightmutantnon-geneticrelating to nervous systemscreeningsocial factorssocial stresstau aggregationtool
项目摘要
Project Abstract
The major goal of this research is to identify the genetic risk factors with functional significance to
dementia in the model organism Drosophila melanogaster. The key aspect of dementia is age-
dependent neurodegeneration that cripples executive functions (e.g. inhibitory control) and
memory. Most dementia studies have focused on memory loss, which is a prominent symptom of
AD - the most common dementia type. While animal models have provided important insights into
the mechanism for memory loss, their utility for dementia gene discovery is limited since the study
of memory loss is time-consuming and laborious. Executive deficits are major symptoms in early
stage AD and related dementias yet largely understudied. We overcome these limitations by
studying inhibitory control deficit as a dementia endophenotype for the discovery of dementia
genes, which is innovative. Our approach is to conduct an unbiased screen for the genetic loci
causing dysfunctional inhibitory control in an age-dependent manner, with or without the non-
genetic risk factors. In this proposal we will also test the hypothesis that the genetic and non-
genetic risk factor interaction has a greater effect on dementia than a genetic factor alone.
Drosophila is tractable for student research training and education as it is easy to handle, allows to
readily apply state-of-the-art tools and approaches, and is cost-and time-effective. There is
currently no other biological research on dementia at UTEP. Dementia prevalence is
disproportionately higher in Hispanics than white Americans thus this study will not only promote
research relevant to our students and community but also increase the representation of Hispanics
in neuroscience research that is disproportionately low at present.
项目摘要
项目成果
期刊论文数量(0)
专著数量(0)
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会议论文数量(0)
专利数量(0)
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Kyung-An Han其他文献
Kyung-An Han的其他文献
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{{ truncateString('Kyung-An Han', 18)}}的其他基金
Social and Environmental Influences on Response Inhibition
社会和环境对反应抑制的影响
- 批准号:
9326341 - 财政年份:2016
- 资助金额:
$ 15.3万 - 项目类别:
Social and Environmental Influences on Response Inhibition
社会和环境对反应抑制的影响
- 批准号:
9182549 - 财政年份:2016
- 资助金额:
$ 15.3万 - 项目类别:
Research Supplement to Promote Diversity in Health-Related Research
促进健康相关研究多样性的研究补充
- 批准号:
8908604 - 财政年份:2014
- 资助金额:
$ 15.3万 - 项目类别:
Monoamine Functions in Drosophila Female Reproduction
单胺在果蝇雌性生殖中的功能
- 批准号:
6969943 - 财政年份:2005
- 资助金额:
$ 15.3万 - 项目类别:
Monoamine Functions in Drosophila Female Reproduction
单胺在果蝇雌性生殖中的功能
- 批准号:
7086370 - 财政年份:2005
- 资助金额:
$ 15.3万 - 项目类别:
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