NEUROSCIENCE AND METABOLIC DISORDERS PROJECT

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 由神经和/或代谢系统失调引起的公共卫生问题对埃尔帕索及其周围社区的居民非常重要。德克萨斯大学埃尔帕索分校(UTEP)是美国/墨西哥边境一流的少数民族服务机构，在我们边境生物医学研究中心(BBRC)的RCMI支持下，该校拥有强大的基础研究项目。在BBRC内，神经科学和代谢紊乱项目(NMDP)进行合作研究，调查导致该地区高度表达的复杂疾病的神经和代谢机制。我们的愿景是，在我们提议的新研究主题(神经和代谢失调、神经毒理学、神经退化和恢复，以及细胞机制和癌症)下，正在进行的和新的合作以及试点研究资助将促进多学科研究，并允许未来对抑郁症、成瘾、糖尿病和肥胖以及癌症等与边境相关的健康状况的治疗和干预进行翻译研究。NMDP的科学家通过使用包含专门化设备和技术支持的优秀核心设施来提高他们的生产力。拟议的活动将为调查人员和方案带来机会，使它们变得更加成熟，并朝着否则可能不可能的方向发展。新招聘的教员将在通过独立项目、试点研究补助金和使用核心设施获得的势头的基础上，促进NMDP内部以及NMDP与BBRC其他项目(毒理学、传染病和免疫学)之间的协同和扩展。这一新研究战略的积极成果将是：1)在获得外部资金方面取得更大的成功；2)同时减少我们对RCMI资金的依赖；3)开发和追求多研究者和/或计划项目类型的拨款申请；以及4)为培训来自代表性不足群体的年轻科学家创造一个富有成效的环境。通过这项研究计划，我们将实现我们的使命，为埃尔帕索/华雷斯社区的人们的健康和教育做出重大贡献，以及NIH和NCRR的使命。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. Public health issues that result from nervous and/or metabolic system dysregulation are highly significant for the residents of El Paso and its surrounding communities. The University of Texas at El Paso (UTEP), a premier minority-serving institution on the U.S./Mexico border, has a robust basic research program made possible by the RCMI support of our Border Biomedical Research Center (BBRC). Within the BBRC the Neuroscience and Metabolic Disorders Project (NMDP) pursues collaborative research that investigates neurological and metabolic mechanisms that contribute to complex diseases that are highly expressed in this region. Our vision is that ongoin and new collaborations, and pilot research grants under our proposed new themes for research (neurological and metabolic dysregulation, neurotoxicology, neurodegeneration and recovery, and cellular mechanisms and cancer), will promote multidisciplinary research and permit future translational studies into therapeutics and interventions for border-relevant health conditions such as depression, addiction, diabetes and obesity, and cancer. Scientists in the NMDP enhance their productivity through the use of outstanding Core facilities which contain specilized equipment and technical support. Opportunities for investigators and programs to become more established and move in directions that likely would not otherwise be possible will result from the proposed activities. New faculty hires will build on the momentum gained through independent projects, pilot research grants and the use of the Core facilities, promoting synergy and expansion within the NMDP and between the NMDP and the other BBRC Projects (Toxicology and Infectious Diseases and Immunology). Positive outcomes of this new research strategy will be: 1) increased success in securing extramural funding; 2) a concurrent decrease in our dependence on RCMI funds; 3) the development and pursuit of multi-investigator and/or program project-type grant applications; and 4) a productive environment for training young scientists from underrepresented groups. Through this research plan, we will achieve our mission to contribute substantially to the health and education of people in the El Paso/Ciudad Juarez community as well as the missions of the NIH and NCRR.