Neuropathology Core

神经病理学核心

基本信息

项目摘要

NEUROPATHOLOGY CORE PROJECT SUMMARY/ABSTRACT The importance of human brain tissue in ADRD research cannot be overstated, both as a resource to explore and define novel molecular pathways, as well as a critical resource for animal researchers who wish to validate their findings in human tissue. The AMP-AD initiative recently launched by NIA is further validation of the importance of human brain tissue in defining disease-relevant pathways, and has resulted in numerous publications that have added to our evolving understanding of AD pathogenesis. The Columbia University ADRC Neuropathology (NP) Core has a long history of serving the wider ADRD research community’s need for well characterized human brain tissue, and we will continue this mission under this new P30 application. The chief function of the NP Core is to provide state-of-the-art diagnostic services, and to collect, maintain, and distribute optimally prepared brain samples to researchers at Columbia and throughout the world. The NP Core also has a responsibility to train and educate the next generation of neurodegenerative disease researchers and brain bankers. Finally, the NP Core will contribute to the investigation of the three pathways that are the scientific focus of this application. With regards to tissue banking and distribution, the NP Core has a well-established procedure for receiving and banking brains, and we will continue this protocol for this new P30 application. Upon death of a donor, one half brain is immersed in formalin and kept for thorough neuropathological evaluation, and the contralateral half is extensively dissected at the fresh state and processed to yield up to 150 blocks and pulverized aliquots of parenchyma. Our samples are barcoded and electronically tracked, which aids in organizing the samples, maintaining them safely, and ultimately speeds the selection of samples for research. With regards to education, the NP Core has a long-standing tradition of educating the next generation of neuroscientists and brain bankers, through weekly brain cutting, monthly clinicopathological conferences, and periodic hosting of visiting neuroscientists throughout the world (since 2001, our methodology has been fully or partially instituted at eight other academic sites). Finally, we will use the resources of the NP core to inform on the three AD-associated biological pathways. Specifically, we will use single-nucleus RNA-seq to ask the following questions: 1) What cell types express the three established genes that relate to the three pathways (i.e. TREM2, APOE, SORL1)?; 2) Is there regional variation in the cell types that express these three genes?, and 3) Does this expression pattern change during successive Braak stages?
神经病理学核心项目摘要/摘要

项目成果

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Andrew Franklin Teich其他文献

Andrew Franklin Teich的其他文献

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{{ truncateString('Andrew Franklin Teich', 18)}}的其他基金

Neuropathology Core
神经病理学核心
  • 批准号:
    10187488
  • 财政年份:
    2020
  • 资助金额:
    $ 31.84万
  • 项目类别:
Neuropathology Core
神经病理学核心
  • 批准号:
    10668247
  • 财政年份:
    2020
  • 资助金额:
    $ 31.84万
  • 项目类别:
A Translational Bioinformatics Approach to Rescuing Synaptic and Neurophysiologic Dysfunction in Alzheimer's Disease
挽救阿尔茨海默病突触和神经生理功能障碍的转化生物信息学方法
  • 批准号:
    10320653
  • 财政年份:
    2018
  • 资助金额:
    $ 31.84万
  • 项目类别:
A Translational Bioinformatics Approach to Rescuing Synaptic and Neurophysiologic Dysfunction in Alzheimer's Disease
挽救阿尔茨海默病突触和神经生理功能障碍的转化生物信息学方法
  • 批准号:
    10441481
  • 财政年份:
    2018
  • 资助金额:
    $ 31.84万
  • 项目类别:
A Translational Bioinformatics Approach to Rescuing Synaptic and Neurophysiologic Dysfunction in Alzheimer's Disease
挽救阿尔茨海默病突触和神经生理功能障碍的转化生物信息学方法
  • 批准号:
    10165445
  • 财政年份:
    2018
  • 资助金额:
    $ 31.84万
  • 项目类别:
An integrative analysis of DNA methylation, transcriptomic changes, and cognitive dysfunction in Alzheimer's disease
阿尔茨海默病 DNA 甲基化、转录组变化和认知功能障碍的综合分析
  • 批准号:
    9353721
  • 财政年份:
    2016
  • 资助金额:
    $ 31.84万
  • 项目类别:
A systems approach to DNA methylation, gene expression, and cognitive dysfunction in Alzheimer's disease
阿尔茨海默病 DNA 甲基化、基因表达和认知功能障碍的系统方法
  • 批准号:
    8869425
  • 财政年份:
    2015
  • 资助金额:
    $ 31.84万
  • 项目类别:
A study of ZCCHC17 regulation of synaptic genes in Alzheimers disease
ZCCHC17对阿尔茨海默病突触基因调控的研究
  • 批准号:
    8757603
  • 财政年份:
    2014
  • 资助金额:
    $ 31.84万
  • 项目类别:
Learning and Adaptation in Primary Visual Cortex
初级视觉皮层的学习和适应
  • 批准号:
    6790437
  • 财政年份:
    2004
  • 资助金额:
    $ 31.84万
  • 项目类别:
Learning and Adaptation in Primary Visual Cortex
初级视觉皮层的学习和适应
  • 批准号:
    6886122
  • 财政年份:
    2004
  • 资助金额:
    $ 31.84万
  • 项目类别:

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生物样本暴露于解冻条件下的等分水平视觉指示器
  • 批准号:
    10357225
  • 财政年份:
    2022
  • 资助金额:
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  • 项目类别:
Aliquot-level visual indicators of biospecimen exposure to thawed conditions
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  • 批准号:
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数字的解剖学和生理学-素数和等分和的统计-
  • 批准号:
    21K13772
  • 财政年份:
    2021
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    $ 31.84万
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    Grant-in-Aid for Early-Career Scientists
Experimental Analysis of Aliquot Sequences
等分序列的实验分析
  • 批准号:
    467312-2014
  • 财政年份:
    2014
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