MRI-compatible high resolution microendoscopic system

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The requested instrument, the OASIS Implant Microendoscope, represents a revolutionary advancement in the methodology of translational research. The unique device is engineered in such a way that mitigates much of the limitations of other available imaging implants. Its lightweight and electronic-free headmount allows more natural behavior to be exhibited, as it is designed to enable the subject animal to respond as freely as possible to its environment. Furthermore, it permits researchers to simultaneously report direct observations of neuronal activation obtained through the implant microendoscope and indirect observations via functional Magnetic Resonance Imaging (fMRI). This method of interrogation is likely to yield incredibly robust empirical findings. Specifically, the proposed projects that will utilize the device will aim to identify the developmental and cellular mechanisms of resting state fMRI, the effects of neonatal anesthesia on brain tissue oxygen dynamics, and understand the physiology of the raphe magnus and its role in visceral pain. At present, NorthShore University HealthSystem does not currently possess an instrument capable of conducting this type of research even though the PI already has obtained the necessary experience and expertise to safely and effectively operate the device with immediate effect. The OASIS Implant Microendoscope along with the enthusiastic institutional support will unquestionably facilitate the progression of research in line with the mission of NIGMS as well as NorthShore University HealthSystem by enabling immediate and impact-driven research to preserve and improve human life.