Developmental disruption of brain tissue oxygen regulation and deficiency of learning after neonatal anesthesia exposure

新生儿麻醉暴露后脑组织氧调节的发育障碍和学习缺陷

• 批准号: 10797738
• 负责人: Daniil Aksenov
• 金额: $ 8.99万
• 依托单位: NORTHSHORE UNIVERSITY HEALTHSYSTEM
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-08-15 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10797738
• 关键词: Anesthesia procedures; Behavioral; Brain; Cephalic; Child; Childhood; Development; Diagnosis; Diagnostic; Electric Stimulation; Exposure to; General Anesthesia; Learning; Magnetism; Medical Imaging; Methods; Modality; Neonatal; Neuronal Plasticity; Operative Surgical Procedures; Oxygen; Persons; Procedures; Property; Regulation; Role; brain tissue; disability; improved; synaptogenesis

Each year, millions of people, including six million children, undergo general anesthesia for surgeries, medical imaging, and other procedures. The potential negative effects of anesthesia on the developing brain are concerning, as they may lead to later learning and behavioral deficits. Currently, there are limited instrumental methods available for diagnosing and predicting anesthesia-induced disabilities, as well as limited treatment options. However, transcranial magnetic and electric stimulation (TMES) is an established, non-invasive method that enables the assessment of the excitatory and inhibitory properties of the brain. In addition to its diagnostic role, specific modalities of TMES can produce long-lasting changes in local brain excitability by stimulating neuronal plasticity and synaptogenesis. It is expected that TMES will aid in both diagnosing and treating disabilities related to anesthesia exposure during childhood.

每年有数百万人，包括六百万儿童，接受全身麻醉 用于外科手术、医学成像和其他程序。的潜在负面影响 麻醉对发育中的大脑的影响是令人担忧的，因为它们可能会导致以后的学习 和行为缺陷目前，有有限的仪器方法可用于 诊断和预测麻醉引起的残疾，以及有限的治疗 选项.然而，经颅磁电刺激（TMES）是一种有效的方法。 建立，非侵入性的方法，使兴奋性和 大脑的抑制特性。除了诊断作用外， TMES可以通过刺激局部大脑兴奋性产生持久的变化， 神经可塑性和突触发生。预计TMES将在这两个方面提供帮助。 诊断和治疗与儿童时期麻醉暴露有关的残疾。