9.4T MRI gradients

9.4T MRI 梯度

• 批准号: 10628143
• 负责人: Daniil Aksenov
• 金额: $ 19.7万
• 依托单位: NORTHSHORE UNIVERSITY HEALTHSYSTEM
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-03-01 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10628143
• 关键词: Anesthesia procedures; Deterioration; Development; Devices; Failure; Functional Magnetic Resonance Imaging; Funding; Health system; Human; Image; Institution; Life; Magnetic Resonance; Magnetic Resonance Imaging; Methodology; Mission; Modality; National Institute of General Medical Sciences; Neonatal; Perinatal Brain Injury; Physiology; Research; Research Personnel; Rest; Risk; System; Translational Research; United States National Institutes of Health; Universities; Visceral pain; design; experience; imager; improved; instrument; preservation

The requested instrument, the gradient system for a 9.4T imager, represents a substantial advancement in the methodology of translational research. This device will replace the current, degrading system currently in use in the imager. The current gradient is suffering from over 15 years of wear, which has led to the deterioration of the insulation materials that separate the gradient and shim coils. Consequently, we have observed that the electrical couplings between the gradient and shim coils caused a significant distortion in the images produced. This indication, among others outlined in the proposal below suggest that the current gradient system is at increasing risk of sudden failure without any warning. The gradient system’s integrated design will be a complete and lasting fix for these issues. Furthermore, it will permit researchers to continue and accomplish important NIH-funded research, through the use of various magnetic resonance (MR) modalities which promote robust empirical findings. The proposed projects that will utilize the system will aim to identify the developmental and cellular mechanisms of resting state functional MR imaging (fMRI) in healthy state and after perinatal brain injury, the MR signature of developmental effects after neonatal anesthesia, understand the physiology of visceral pain, etc. At present, NorthShore University HealthSystem does not currently possess an alternative instrument capable of conducting this type of research even though the PI and their team already has obtained the necessary experience and expertise to safely and effectively implement and operate the gradient system with immediate effect. The gradient system along with the enthusiastic institutional support will unquestionably facilitate the progression of research in line with the mission of NIGMS as well as NorthShore University HealthSystem by enabling immediate and impact-driven research to preserve and improve human life.

所要求的仪器，9.4T成像仪的梯度系统，代表了一个实质性的 翻译研究方法的进步。这个装置将取代目前的， 目前在成像仪中使用的降级系统。目前的梯度是遭受超过15 多年的磨损，这导致了绝缘材料的恶化， 梯度和匀场线圈。因此，我们观察到， 梯度和匀场线圈在所产生的图像中引起显著的失真。这 除其他外，以下提案中概述的迹象表明，目前的梯度制度 在没有任何警告的情况下突然失败的风险越来越大。梯度系统是集成的 设计将是这些问题的一个完整和持久的解决方案。此外，它还将允许研究人员 继续并完成重要的NIH资助的研究，通过使用各种 磁共振（MR）模态，其促进稳健的经验发现。拟议 将利用该系统的项目将旨在确定发展和细胞 静息态功能磁共振成像（fMRI）在健康和围产期后的机制 脑损伤，新生儿麻醉后发育影响的MR特征，了解 内脏疼痛的生理学等。目前，北岸大学卫生系统不 目前拥有一种能够进行这种研究的替代工具， 尽管PI及其团队已经获得了必要的经验和专业知识， 安全和有效地实施和操作梯度系统，立即生效。的 梯度系统沿着热情的制度支持，无疑将促进 研究进展符合NIGMS以及北岸大学的使命 卫生系统，使即时和影响驱动的研究，以维护和改善 人类生活