9.4T MRI gradients

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The requested instrument, the gradient system for a 9.4T imager, represents a substantial advancement in the methodology of translational research. This device will replace the current, degrading system currently in use in the imager. The current gradient is suffering from over 15 years of wear, which has led to the deterioration of the insulation materials that separate the gradient and shim coils. Consequently, we have observed that the electrical couplings between the gradient and shim coils caused a significant distortion in the images produced. This indication, among others outlined in the proposal below suggest that the current gradient system is at increasing risk of sudden failure without any warning. The gradient system’s integrated design will be a complete and lasting fix for these issues. Furthermore, it will permit researchers to continue and accomplish important NIH-funded research, through the use of various magnetic resonance (MR) modalities which promote robust empirical findings. The proposed projects that will utilize the system will aim to identify the developmental and cellular mechanisms of resting state functional MR imaging (fMRI) in healthy state and after perinatal brain injury, the MR signature of developmental effects after neonatal anesthesia, understand the physiology of visceral pain, etc. At present, NorthShore University HealthSystem does not currently possess an alternative instrument capable of conducting this type of research even though the PI and their team already has obtained the necessary experience and expertise to safely and effectively implement and operate the gradient system with immediate effect. The gradient system along with the enthusiastic institutional support will unquestionably facilitate the progression of research in line with the mission of NIGMS as well as NorthShore University HealthSystem by enabling immediate and impact-driven research to preserve and improve human life.