9.4T MRI gradients

所要求的仪器，9.4T成像仪的梯度系统，代表了一个实质性的 翻译研究方法论的进展。这个装置将取代电流， 成像器中目前使用的降级系统。目前的梯度正在遭受超过15 多年的磨损，导致隔热层绝缘材料的劣化 渐变和垫片线圈。因此，我们观察到 渐变和垫片线圈在产生的图像中造成了严重失真。这 以下提案中概述的其他指标表明，目前的梯度制度 在没有任何警告的情况下，突然故障的风险越来越大。梯度系统的集成 设计将是这些问题的彻底和持久的解决方案。此外，它还将允许研究人员 继续并完成NIH资助的重要研究，通过使用各种 磁共振(MR)模式，促进强有力的经验发现。建议数 将利用该系统的项目将旨在识别发育和细胞 健康状态和围产期静息功能磁共振成像的机制 脑损伤，新生儿麻醉后发育影响的磁共振信号，理解 内脏疼痛的生理学等。目前，北岸大学医疗系统不 目前拥有能够进行这类研究的替代仪器，甚至 尽管PI和他们的团队已经获得了必要的经验和专业知识来 安全有效地实施和运行梯度制度，即刻生效。这个 梯度制度加上热情的机构支持，无疑将促进 与NIGMS和北岸大学的使命相一致的研究进展 HealthSystem通过支持即时和受影响驱动的研究来保护和改进 人类的生命。

The requested instrument, the gradient system for a 9.4T imager, represents a substantial advancement in the methodology of translational research. This device will replace the current, degrading system currently in use in the imager. The current gradient is suffering from over 15 years of wear, which has led to the deterioration of the insulation materials that separate the gradient and shim coils. Consequently, we have observed that the electrical couplings between the gradient and shim coils caused a significant distortion in the images produced. This indication, among others outlined in the proposal below suggest that the current gradient system is at increasing risk of sudden failure without any warning. The gradient system’s integrated design will be a complete and lasting fix for these issues. Furthermore, it will permit researchers to continue and accomplish important NIH-funded research, through the use of various magnetic resonance (MR) modalities which promote robust empirical findings. The proposed projects that will utilize the system will aim to identify the developmental and cellular mechanisms of resting state functional MR imaging (fMRI) in healthy state and after perinatal brain injury, the MR signature of developmental effects after neonatal anesthesia, understand the physiology of visceral pain, etc. At present, NorthShore University HealthSystem does not currently possess an alternative instrument capable of conducting this type of research even though the PI and their team already has obtained the necessary experience and expertise to safely and effectively implement and operate the gradient system with immediate effect. The gradient system along with the enthusiastic institutional support will unquestionably facilitate the progression of research in line with the mission of NIGMS as well as NorthShore University HealthSystem by enabling immediate and impact-driven research to preserve and improve human life.