Anesthesia-induced learning deficiency and brain hyperoxia
麻醉引起的学习缺陷和大脑高氧血症
基本信息
- 批准号:9688777
- 负责人:
- 金额:$ 4.84万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2016
- 资助国家:美国
- 起止时间:2016-08-15 至 2021-05-31
- 项目状态:已结题
- 来源:
- 关键词:AdolescenceAdolescentAgeAirAnesthesia proceduresAnestheticsAnimal ModelAnimalsApoptosisAttentionBehavioralBiochemicalBiological MarkersBlinkingBrainCell DeathChildCholineClinicalClinical ResearchCognitionCognitiveConsumptionDevelopmentDiffusionElectrophysiology (science)EquilibriumExposure toGene ExpressionGeneral AnesthesiaGlutamatesGoalsHippocampus (Brain)HourHyperoxiaImpairmentInfantInhalation AnestheticsIsofluraneLeadLearningLearning DisabilitiesLifeLightLinkLiteratureMagnetic Resonance ImagingMagnetic Resonance SpectroscopyMeasurementMeasuresMemoryMyelinN-acetylaspartateNeurogliaNeuronsOperative Surgical ProceduresOryctolagus cuniculusOxidative StressOxygenPathologicPathologyPhysiologyPlayProceduresProductionProtocols documentationReactive Oxygen SpeciesReportingRiskSignal TransductionSourceStructureTestinganxiety-like behaviorawakeaxon growthbehavior measurementbrain tissuecerebral atrophyclinical practiceconditioningexperimental studyfield studygamma-Aminobutyric Acidinfancymyelinationneuron developmentneuron lossneuronal survivalneurotoxicneurotoxicityresearch studyresponsesevoflurane
项目摘要
PROJECT SUMMARY
Cognitive damage induced by anesthesia delivered in the course of surgery and other clinical
procedures has been the focus of increasing attention in recent years. A growing body of
literature has established that anesthesia can potentially lead to pathological effects including
increased apoptosis and disruption of myelin formation, ultimately resulting in learning
deficiencies. However, the mechanisms underlying these anesthesia-induced changes are not
well understood. We have reported previously that isoflurane anesthesia significantly increases
the oxygen level in brain tissue compared to the awake state. Oxidative stress is a well-
established source of neurotoxicity which is known to induce neuronal and glial cell death and
can disrupt myelin formation. Brain hyperoxia could therefore play a key role in explaining the
learning impairments associated with anesthesia. The proposed study will examine the
relationship between anesthesia, brain oxygen level, and structural, biochemical, and behavioral
measures of pathology. In Aim 1, we will characterize oxygen, electrophysiological responses,
and reactive oxygen species under two common inhaled anesthetics (isoflurane and
sevoflurane,) in air and in 80% oxygen. In Aim 2, we will evaluate the effect of anesthesia
exposure on behavioral learning. In Aim 3, we will evaluate the structural and biochemical
changes in brain induced by anesthesia exposure. These studies will provide a deeper
understanding of the physiology of anesthesia and its relationship with oxygen levels in the
brain. Behavioral, MRI, oxygen, and electrophysiological measurements will provide information
on the short- and long-term influence of anesthesia/hyperoxia on brain structure and cognition.
项目总结
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Daniil Aksenov其他文献
Daniil Aksenov的其他文献
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{{ truncateString('Daniil Aksenov', 18)}}的其他基金
MRI-compatible high resolution microendoscopic system
兼容 MRI 的高分辨率显微内窥镜系统
- 批准号:
10415460 - 财政年份:2022
- 资助金额:
$ 4.84万 - 项目类别:
Role of interneurons in brain tissue oxygen regulation
中间神经元在脑组织氧调节中的作用
- 批准号:
10409799 - 财政年份:2018
- 资助金额:
$ 4.84万 - 项目类别:
Role of interneurons in brain tissue oxygen regulation
中间神经元在脑组织氧调节中的作用
- 批准号:
9752001 - 财政年份:2018
- 资助金额:
$ 4.84万 - 项目类别:
Role of interneurons in brain tissue oxygen regulation
中间神经元在脑组织氧调节中的作用
- 批准号:
10204133 - 财政年份:2018
- 资助金额:
$ 4.84万 - 项目类别:
Developmental disruption of brain tissue oxygen regulation and deficiency of learning after neonatal anesthesia exposure
新生儿麻醉暴露后脑组织氧调节的发育障碍和学习缺陷
- 批准号:
10378327 - 财政年份:2016
- 资助金额:
$ 4.84万 - 项目类别:
Developmental disruption of brain tissue oxygen regulation and deficiency of learning after neonatal anesthesia exposure
新生儿麻醉暴露后脑组织氧调节的发育障碍和学习缺陷
- 批准号:
10686998 - 财政年份:2016
- 资助金额:
$ 4.84万 - 项目类别:
Developmental disruption of brain tissue oxygen regulation and deficiency of learning after neonatal anesthesia exposure
新生儿麻醉暴露后脑组织氧调节的发育障碍和学习缺陷
- 批准号:
10797738 - 财政年份:2016
- 资助金额:
$ 4.84万 - 项目类别:
Anesthesia-induced learning deficiency and brain hyperoxia
麻醉引起的学习缺陷和大脑高氧血症
- 批准号:
9330887 - 财政年份:2016
- 资助金额:
$ 4.84万 - 项目类别:
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