Console and Probe Upgrade for a 700 MHz NMR Spectrometer
700 MHz NMR 波谱仪的控制台和探头升级
基本信息
- 批准号:10415275
- 负责人:
- 金额:$ 101.69万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-07-15 至 2023-07-14
- 项目状态:已结题
- 来源:
- 关键词:15 year oldBiomolecular Nuclear Magnetic ResonanceCommunitiesComplexDiseaseElectronicsFacultyFundingHealthHumanIowaLifeManufacturer NameMethodologyModernizationNatural ProductsNuclearNuclear Magnetic ResonancePerformanceProteinsRelaxationResearchResearch PersonnelResearch Project GrantsServicesStructural BiologistStructureSystemTimeUnited States National Institutes of HealthUniversitiesdrug discoveryexperienceexperimental studyfaculty researchinstrumentinstrumentationmetabolomicsprogramsrepairedsmall molecule
项目摘要
The Iowa State University Biomolecular NMR Facility is seeking funding to replace and upgrade
the console, cryoprobe and accessories for its 700 MHz Nuclear Magnetic Resonance (NMR)
spectrometer. This instrument serves a vibrant group of research faculty at Iowa State
University (ISU) that pursue NIH funded research programs tackling questions related to
biomolecular structures and complexes, natural products, protein disorder/aggregation,
metabolomics, and small molecule drug discovery. The requested upgrade will dramatically
increase access to high field NMR spectrometers at ISU allowing the long-term research
objectives of our faculty to be realized. As the community of structural biologists at ISU has
expanded rapidly over the past decade, the Biomolecular NMR Facility has experienced
increased demand for NMR time. The specific request includes replacing all console electronics,
all magnet accessories such as shims, the complete cryoprobe system and adding an
autosampler. The original 54 mm bore 16.5 T Bruker UltraShield superconducting magnet will
be maintained. It is typical for NMR magnets to be serviceable for several decades (much longer
than consoles). The existing 15-year-old console has reached the end of its useful life as an
instrument for state-of-the-art biomolecular NMR research. The need for repair downtime on
the 700 MHz instrument has increased steadily in recent years while at the same time the
manufacturer no longer guarantees the availability of replacement parts. Even when in good
operational condition, the performance of the spectrometer is not up to the standards of
modern methodologies, particularly the nuclear relaxation dispersion experiments required by
ISU researchers. Thus, a successful upgrade of the 700 MHz NMR spectrometer at ISU will
enhance ongoing research projects related to human health by providing greater access to high
field instrumentation as well as additional capabilities currently not available on the 700 MHz
instrument.
爱荷华州立大学生物分子核磁共振设施正在寻求资金来替换和升级
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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AMY H ANDREOTTI其他文献
AMY H ANDREOTTI的其他文献
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{{ truncateString('AMY H ANDREOTTI', 18)}}的其他基金
Molecularly imprinted nanoparticles as new tools to elucidate T cell signaling events
分子印迹纳米颗粒作为阐明 T 细胞信号传导事件的新工具
- 批准号:
10452166 - 财政年份:2022
- 资助金额:
$ 101.69万 - 项目类别:
Molecularly imprinted nanoparticles as new tools to elucidate T cell signaling events
分子印迹纳米颗粒作为阐明 T 细胞信号传导事件的新工具
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10559701 - 财政年份:2022
- 资助金额:
$ 101.69万 - 项目类别:
Screening for inhibitors of the T cell Tec kinase, ltk
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8260866 - 财政年份:2008
- 资助金额:
$ 101.69万 - 项目类别:
Regulation of T Cell Signaling: Structural Studies of PLCgamma1
T 细胞信号传导的调节:PLCgamma1 的结构研究
- 批准号:
7803735 - 财政年份:2008
- 资助金额:
$ 101.69万 - 项目类别:
Regulation of T Cell Signaling: Structural Studies of PLCgamma1
T 细胞信号传导的调节:PLCgamma1 的结构研究
- 批准号:
8068838 - 财政年份:2008
- 资助金额:
$ 101.69万 - 项目类别:
Regulation of T Cell Signaling: Structural Studies of PLCgamma1
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- 批准号:
7469611 - 财政年份:2008
- 资助金额:
$ 101.69万 - 项目类别:
Regulation of T Cell Signaling: Structural Studies of PLCgamma1
T 细胞信号传导的调节:PLCgamma1 的结构研究
- 批准号:
7615554 - 财政年份:2008
- 资助金额:
$ 101.69万 - 项目类别:
STRUCTURAL STUDIES OF A T CELL SPECIFIC TYROSINE KINASE
T 细胞特异性酪氨酸激酶的结构研究
- 批准号:
6137270 - 财政年份:1999
- 资助金额:
$ 101.69万 - 项目类别:
STRUCTURAL STUDIES OF A T CELL SPECIFIC TYROSINE KINASE
T 细胞特异性酪氨酸激酶的结构研究
- 批准号:
6488716 - 财政年份:1999
- 资助金额:
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