Advanced Materials to Improve Moisture Management for Prosthetic Socket Liners

先进材料可改善假肢接受腔衬垫的水分管理

• 批准号: 9192453
• 负责人: Paul D. Marasco
• 金额: --
• 依托单位: LOUIS STOKES CLEVELAND VA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9192453
• 关键词: Adsorption; Affect; Amputees; Back; Cellulose; Characteristics; Clinical; Collection; Coupled; Development; Devices; Diffuse; Diffusion; Engineering; Evaluation; Extravasation; Filler; Friction; Heel; Hydration status; Hydrophobicity; Hygiene; Infection; Influenza; Limb Prosthesis; Limb structure; Link; Lower Extremity; Maintenance; Mechanics; Modernization; Molecular Weight; Natural regeneration; Participant; Patients; Performance; Physical therapy; Play; Polymers; Polyurethanes; Population; Production; Property; Prosthesis; Regimen; Role; Sampling; Shear Strength; Silicones; Skin; Stress; Suction; Suspensions; Sweat; Sweat test; System; Technology; Testing; Tissues; Traction; Upper Extremity; Vacuum; Veterans; Walkers; Walking; Water; base; clay; clinical practice; crosslink; design; diabetic; ethylene glycol; hydrophilicity; improved; mechanical properties; microbial; nanocomposite; nanocrystal; polydimethylsiloxane; prevent; prosthetic socket; prototype; residual limb; retinal rods; standard of care; uptake

In modern prosthetics a suction liner provides a mechanical connection to the rigid socket by “gripping” the residual limb of the patient by either skin traction or suction. Conventionally, liners are made from materials that are impermeable to water such as silicone and polyurethane. Prolonged moisture accumulation inside the liner adversely affects fit and contributes to issues such as maceration (tissue softening from constant water exposure), breakdown, and infection, as well as issues of comfort and hygiene.  Managing this issue could revolutionize the clinical implementation of this widely used suspension system. We propose to develop a new type of advanced-material prosthetic liner system that maintains skin traction and suction but also absorbs, wicks, channels, and manages the water from sweat. This material will improve clinical practice by providing a more stable, comfortable, and less problematic interface between the limb and socket. Our objective is to develop a highly cross-linked prototype hydrated material system, for use in place of the water-impermeable silicone liner, to maintain airless skin traction and suction while managing sweat and keeping a static volume in relation to water content. This new liner material will require the development of two advanced materials, a sweat- transporting medium incorporating silicone cellulose nanocrystal nanocomposites (CNCs), and a polymer/clay aerogel which can absorb and retain moisture until it is deliberately removed. Both of these materials will be developed and tested to optimize their mechanical and sweat-diffusion properties. Finally, these materials will be layered along with a third, sealant layer made of standard liner silicone into a three-layered prototype for further mechanical, sweat management, durability, and regeneration testing as well as hygiene examination coupled to functional evaluation of the material in a rigid  walking boot. Improving water management in this critical component will fundamentally improve standard of care for a large population of lower and upper limb amputees.

在现代假肢中，吸气衬里提供了与刚性的机械连接 通过皮肤牵引或自杀“抓住”患者残留的肢体插座。 通常，线性是由不渗透的材料制成的，例如 有机硅和聚氨酯。长时间的水分积聚在衬里内部不利 影响拟合并导致浸渍等问题（恒定的组织软化 水暴露），分解和感染以及舒适和卫生问题。 管理这个问题可能会彻底改变此广泛使用的临床实施 悬架系统。 我们建议开发一种新型的高级物质假体衬里系统 保持皮肤牵引和任务，但还可以吸收，灯芯，频道并管理 汗水的水。该材料将通过提供更稳定的， 舒适，肢体和插座之间的问题界面更少。我们的目标 是要开发高度交联的原型水合物质系统，以供适当的使用 可耐水的硅胶衬里，以保持无空的皮肤牵引力和任务 同时管理汗水并保持与水含量有关的静态体积。这 新的衬里材料将需要开发两种高级材料，一种汗水 - 运输培养基掺入有机硅纤维素纳米晶纳米复合材料 （CNCS）和一个可以吸收和保留水分直到其的聚合物/粘土气凝胶 故意删除。这两种材料都将经过开发和测试以优化 它们的机械和汗水扩散特性。最后，这些材料将分层 以及三分之一的密封剂层由标准衬里有机硅制成的三层 用于进一步机械，汗水管理，耐用性和再生的原型 测试以及卫生检查，并在刚性中对材料的功能评估结合 步行靴。改善此关键组成部分的水管理将从根本上 改善上肢和上肢截肢者人群的护理标准。