Identifying Biomarkers of Post-traumatic Stress Disorder in U.S. Veterans using an Integrative Multi-Omics Approach

使用综合多组学方法识别美国退伍军人创伤后应激障碍的生物标志物

• 批准号: 10417012
• 负责人: Janitza Liz Montalvo-Ortiz
• 金额: --
• 依托单位: VA CONNECTICUT HEALTHCARE SYSTEM
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-01-01 至 2024-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10417012
• 关键词: Address; Age; Arousal; Bioinformatics; Biological Markers; Candidate Disease Gene; Chronic; Cognition; Cohort Studies; DNA; DNA Methylation; Data; Data Analyses; Data Set; Disease; Environmental Risk Factor; Epigenetic Process; Etiology; Event; Exposure to; Funding; Gene Expression; Gene set enrichment analysis; Genes; Genetic; Genome Scan; Genomics; Goals; Grant; Health; Healthcare; Healthcare Systems; Institution; Interdisciplinary Study; International; Knowledge; Lead; Learning; Linear Regressions; Longitudinal Studies; Mediation; Mendelian randomization; Mental disorders; Mentorship; Methods; Methylation; Military Personnel; Modeling; Monitor; Network-based; Neurosciences; Pathway Analysis; Peripheral; Phenotype; Positioning Attribute; Post-Traumatic Stress Disorders; Prevalence; Prevention; Prevention strategy; Psychiatry; Publishing; RNA; Research; Research Personnel; Research Training; Residual state; Role; Sample Size; Sampling; Site; Statistical Methods; Symptoms; Tissue-Specific Gene Expression; Tissues; Training; Transcript; Trauma; Veterans; Work; affective disturbance; base; bioinformatics tool; collaborative environment; combat; differential expression; disorder risk; epigenetic marker; epigenomics; experience; functional genomics; gene network; genome wide association study; genome-wide; genome-wide analysis; improved; individual variation; innovation; insight; longitudinal analysis; molecular marker; multidisciplinary; multilevel analysis; multiple omics; novel; personalized care; programs; psychiatric genomics; recruit; reference genome; resilience; saliva sample; skills; supportive environment; symposium; tool; transcriptome sequencing; transcriptomics

The ultimate goal of the CDA-2 is for Dr. Montalvo-Ortiz to obtain training in advanced methods of statistical genetics, functional genomics and bioinformatics to identify molecular biomarkers of posttraumatic stress disorder (PTSD) that can help monitor the progression of PTSD and inform prevention efforts and personalized care for U.S. veterans. To accomplish this goal, she will investigate the epigenomics and transcriptomics of PTSD in veterans using an integrative multi-omics approach. This study is innovative because it represents the largest longitudinal study, to date, of the epigenomics of PTSD in U.S. veterans, will address the causality of the epigenetic biomarkers identified, and will use cutting-edge bioinformatic methods to prioritize biomarkers for PTSD by integrating different datasets. This study will leverage current knowledge and provide novel insights on the etiology of PTSD needed to improve the healthcare for U.S. veterans that suffer from this disorder. The proposed research and training plans are highly complementary; Dr. Montalvo-Ortiz will acquire crucial new knowledge and skillsets that will advance her work to include 1) longitudinal analysis of genome-wide DNA methylation data; 2) RNA-sequencing analysis; 3) integration of multi- omics (DNA methylation-gene expression) datasets; and 4) functional genomics analysis using existing and novel bioinformatics tools. This CDA-2 grant will augment her neuroscience training and initial exposure in the study of the effects of trauma in psychiatric disorders with advanced and cutting-edge skills in psychiatric genomics and bioinformatics. Her mentorship is composed by a multidisciplinary group of established field-leading researchers at VA CT Healthcare and Yale. The innovative research and the supportive and collaborative environment of these institutions will equip her well in developing into an independent VA researcher with the tools necessary to conduct rigorous integrative multi-omics research on some of the most prevalent and disabling psychiatric disorders in U.S. veterans. ! !

CDA-2的最终目标是让Montalvo-Ortiz博士获得高级方法的培训