Development of bioactive graphene based scaffolds for tissue repair

开发用于组织修复的生物活性石墨烯支架

• 批准号: 10069763
• 金额: $ 63.67万
• 依托单位: PROMETHEUS REGENERATION R&D LIMITED
• 依托单位国家: 英国
• 项目类别: Collaborative R&D
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=10069763
• 关键词: Development; bioactive; graphene; based; scaffolds

Arthritis is a disease of aging leading to pain, lack of joint movement, particularly in hips and knees, and poor quality of life. The Global Burden of Disease Study 2019 reported those living with osteoarthritis had more than doubled since 1990 and this trend will continue due to "the epidemic of obesity". Knee osteoarthritis accounted for 61% of cases. In the UK, around 33% of those over 45 have sought treatment for osteoarthritis. The number with knee osteoarthritis is \>5million and estimated to increase a further 30% by 2030\. Estimated UK direct healthcare costs for treating arthritis in 2017 were £10.2billion. There is a rapidly increasing demand for treatment of osteoarthritis in young (35-55 years old) high activity patients who are still within their working life, so costs to society include the loss of productivity (36 million lost working days in the UK per year), general and psychological health, as well as costs of direct treatment. It is widely accepted by orthopaedic scientific societies and surgeons that conservative treatment fails many of these patients but that current joint replacement technologies, although very successful in older patients, are not suitable or efficient. Therefore, a new approach is needed to tackle this problem and return these individuals to their chosen lifestyle.Current knee replacement implants are made of plastic, metal and ceramics and cannot, like our natural bodies, repair themselves. Eventually they wear out. The operation to replace them, revision knee surgery, is more difficult and more likely to have problems than the initial surgery. Therefore, a knee replacement that does not wear out is desirable. To make this possible, we will develop constructs that make tissues to be used to replace areas damaged by osteoarthritis. We have already made supporting structures that are strong enough to be implanted and support cells to grow. This project will further develop these materials to regenerate complex tissues. This will remove the need to use metal, plastic, or ceramic to mend the knee joint. This will have other benefits, such as giving better movement as it is the same as a normal knee and reducing the chances of serious infections after operations by reducing the risk of biofilm formation. It will preserve the current approach to knee surgery so also allowing patients to benefit from the advances that have been made in knee surgery over the last 30 years which have significantly improved functional outcomes.

关节炎是一种衰老疾病，会导致疼痛、关节运动不足（尤其是臀部和膝盖）以及生活质量差。 2019 年全球疾病负担研究报告称，自 1990 年以来，患有骨关节炎的人数增加了一倍多，并且由于“肥胖的流行”，这一趋势将持续下去。膝骨关节炎占病例的61%。在英国，45 岁以上的人中约有 33% 曾寻求骨关节炎治疗。患有膝骨关节炎的人数已超过 500 万，预计到 2030 年将进一步增加 30%。 2017 年英国治疗关节炎的直接医疗费用估计为 102 亿英镑。仍在工作的年轻（35-55 岁）高活动患者对骨关节炎治疗的需求迅速增加，因此社会成本包括生产力损失（英国每年损失 3600 万个工作日）、一般健康和心理健康以及直接治疗费用。骨科学会和外科医生普遍认为，保守治疗对许多此类患者无效，而目前的关节置换技术虽然在老年患者中非常成功，但并不合适或有效。因此，需要一种新的方法来解决这个问题，让这些人恢复到他们选择的生活方式。目前的膝关节置换植入物由塑料、金属和陶瓷制成，不能像我们的自然身体一样进行自我修复。最终它们会磨损。替代它们的手术，即膝关节翻修手术，比初次手术更困难，也更容易出现问题。因此，不磨损的膝关节置换术是可取的。为了实现这一目标，我们将开发制造组织的结构，用于替代骨关节炎受损的区域。我们已经制造了足够坚固的支撑结构，可以植入并支持细胞生长。该项目将进一步开发这些材料来再生复杂的组织。这将消除使用金属、塑料或陶瓷来修复膝关节的需要。这还有其他好处，例如与正常膝盖一样提供更好的运动能力，并通过降低生物膜形成的风险来减少手术后严重感染的机会。它将保留当前的膝关节手术方法，从而使患者受益于过去 30 年膝关节手术所取得的进步，这些进步显着改善了功能结果。