权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Impact of sensory impairments on movement in children with cerebral palsy

感觉障碍对脑瘫儿童运动的影响

基本信息

批准号：
10417072
负责人：
Kathleen Margaret Friel
金额：
$ 38.64万
依托单位：
WINIFRED MASTERSON BURKE MED RES INST
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-09-13 至 2024-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10417072
关键词：
Abnormal coordination Affect Area Brain Brain region Cerebral Palsy Child Childhood Childhood Neurological Disorder Clinical Complex Cutaneous Data Development Diffusion Diffusion Magnetic Resonance Imaging Discrimination Esthesia Exhibits Functional disorder Goals Hand Impairment Intervention Lesion Lifting Limb structure Location Magnetic Resonance Measures Modality Motion Motor Motor Pathways Movement Movement Disorders Outcome Parietal Pathway interactions Persons Physiological Plant Roots Play Population Positioning Attribute Posture Predictive Factor Proprioception Recovery Rehabilitation therapy Research Sensorimotor functions Sensory Spastic Cerebral Palsy Stereognosis Surface System Tactile Testing Texture Therapeutic Touch sensation Upper Extremity Work base disability evidence base expectation grasp improved insight motor deficit motor disorder motor impairment nervous system disorder new therapeutic target novel novel strategies sensorimotor system sensory integration sensory system somatosensory spasticity targeted treatment therapy development tractography

项目摘要

PROJECT SUMMARY Cerebral palsy (CP) is the most common pediatric neurological disorder. CP is caused by damage to brain areas during development. CP results in weakness, altered tone and abnormal coordination. In unilateral spastic CP (USCP), the damage has a unilateral predominance. Although CP is defined as a motor disability, approximately 80% of people with USCP have deficits in sensation that limit the extent of rehabilitation. There is a poor understanding of how the sensory and motor systems interact in children with USCP. Impairments in motor and sensory function have largely been studied in isolation (rather than together) in children with USCP, even though voluntary movement requires the integration of sensory and motor processing. Moreover, while the motor system is better-characterized, there is still a limited understanding of how the location, type, and size of a child’s lesion impacts sensorimotor processing. There is an urgent need to identify and quantify sensory factors that impair movement in children with USCP. Our long-term goal is to develop evidence-based ways to improve movement in children with USCP. The overall objective for this project is to determine how fine touch sensation and sensation of limb position contribute to movement deficits in children with USCP. To meet our goal, we must not only know how sensory systems impact impairment in movement, but we must determine how a child’s lesion and brain connectivity contributes to these impairments. Our central hypothesis is that sensory dysfunction plays a key role in the ability of children with USCP to engage in functional, skillful movements. We also hypothesize that damage to specific brain regions cause specific kinds of impairments. The rationale for the proposed work is that demonstration of a strong relationship between sensory impairments and movement deficits will steer the development of therapies that engage children in the use of sensory information during meaningful complex tasks, with the goal of boosting motor function. !

项目摘要脑性瘫痪（CP）是最常见的小儿神经系统疾病。CP是由损坏大脑在发育过程中。CP导致虚弱、音调改变和协调异常。单侧痉挛性CP（USCP），损害以单侧为主。虽然CP被定义为运动障碍，大约80%的USCP患者存在感觉缺陷，这限制了康复的程度。那里对于患有USCP的儿童的感觉和运动系统如何相互作用的理解很差。中的减损运动和感觉功能在很大程度上是单独（而不是一起）研究USCP儿童的，尽管自主运动需要感觉和运动处理的整合。而且，尽管虽然运动系统的特征更好，但对运动系统的位置、类型和运动方式的理解仍然有限，儿童病变的大小会影响感觉运动处理。迫切需要确定和量化影响USCP儿童运动的感觉因素。我们的长期目标是开发基于证据的方法来改善USCP儿童的运动。本项目的总体目标是确定如何精细触觉和肢体位置的感觉导致USCP儿童的运动缺陷。为了实现我们的目标，我们不仅要知道感官系统影响运动障碍，但我们必须确定儿童的病变和大脑连接导致了这些损伤。我们的中心假设是感觉功能障碍在患有USCP的儿童进行功能性、熟练运动的能力。我们还假设，特定的大脑区域会导致特定类型的损伤。拟议工作的理由是，证明感觉障碍和运动缺陷之间的密切关系将引导开发治疗方法，使儿童在有意义的复杂过程中使用感官信息，任务，目的是提高运动功能。 !