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Impact of sensory impairments on movement in children with cerebral palsy

感觉障碍对脑瘫儿童运动的影响

基本信息

批准号：
10417072
负责人：
Kathleen Margaret Friel
金额：
$ 38.64万
依托单位：
WINIFRED MASTERSON BURKE MED RES INST
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-09-13 至 2024-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10417072
关键词：
Abnormal coordination Affect Area Brain Brain region Cerebral Palsy Child Childhood Childhood Neurological Disorder Clinical Complex Cutaneous Data Development Diffusion Diffusion Magnetic Resonance Imaging Discrimination Esthesia Exhibits Functional disorder Goals Hand Impairment Intervention Lesion Lifting Limb structure Location Magnetic Resonance Measures Modality Motion Motor Motor Pathways Movement Movement Disorders Outcome Parietal Pathway interactions Persons Physiological Plant Roots Play Population Positioning Attribute Posture Predictive Factor Proprioception Recovery Rehabilitation therapy Research Sensorimotor functions Sensory Spastic Cerebral Palsy Stereognosis Surface System Tactile Testing Texture Therapeutic Touch sensation Upper Extremity Work base disability evidence base expectation grasp improved insight motor deficit motor disorder motor impairment nervous system disorder new therapeutic target novel novel strategies sensorimotor system sensory integration sensory system somatosensory spasticity targeted treatment therapy development tractography

项目摘要

PROJECT SUMMARY Cerebral palsy (CP) is the most common pediatric neurological disorder. CP is caused by damage to brain areas during development. CP results in weakness, altered tone and abnormal coordination. In unilateral spastic CP (USCP), the damage has a unilateral predominance. Although CP is defined as a motor disability, approximately 80% of people with USCP have deficits in sensation that limit the extent of rehabilitation. There is a poor understanding of how the sensory and motor systems interact in children with USCP. Impairments in motor and sensory function have largely been studied in isolation (rather than together) in children with USCP, even though voluntary movement requires the integration of sensory and motor processing. Moreover, while the motor system is better-characterized, there is still a limited understanding of how the location, type, and size of a child’s lesion impacts sensorimotor processing. There is an urgent need to identify and quantify sensory factors that impair movement in children with USCP. Our long-term goal is to develop evidence-based ways to improve movement in children with USCP. The overall objective for this project is to determine how fine touch sensation and sensation of limb position contribute to movement deficits in children with USCP. To meet our goal, we must not only know how sensory systems impact impairment in movement, but we must determine how a child’s lesion and brain connectivity contributes to these impairments. Our central hypothesis is that sensory dysfunction plays a key role in the ability of children with USCP to engage in functional, skillful movements. We also hypothesize that damage to specific brain regions cause specific kinds of impairments. The rationale for the proposed work is that demonstration of a strong relationship between sensory impairments and movement deficits will steer the development of therapies that engage children in the use of sensory information during meaningful complex tasks, with the goal of boosting motor function. !

项目总结