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Program for Interdisciplinary Training in CHemical Biology

化学生物学跨学科培训计划

基本信息

批准号：
10418768
负责人：
Michael S Kay
金额：
$ 18.72万
依托单位：
UNIVERSITY OF UTAH
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-07-01 至 2024-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10418768
关键词：
Biology Chemicals Training programs

项目摘要

ABSTRACT Chemical Biology is an interdisciplinary science that requires crosstraining in both chemistry and biology. This Training Grant application (PITCH – Program for Interdisciplinary Training in CHemical Biology) requests support for an interdepartmental Chemical Biology Training Program at the University of Utah. This Program seeks to extend the benefits of the highly successful Biological Chemistry Program, an interdisciplinary 1st-year graduate program that trains students to pursue research on the chemistry/biology interface, to the entire PhD period. The Program consists of individualized research training under the guidance of 37 faculty members from the College of Science, College of Pharmacy, and School of Medicine, which are in close proximity. PITCH will supplement the training program in each student’s home department (from which they receive their PhD) and provide a co-mentor that complements the expertise of the primary mentor. The Steering Committee selects Trainees, monitors their progress, and organizes PITCH activities. The PITCH mentors provide a diverse interdisciplinary training environment in Chemical Biology. Prospective predoctoral trainees are admitted to graduate school through the Biological Chemistry, Chemistry, or MD/PhD programs and compete for two years of PITCH support starting early in their second year based on a competitive application process that evaluates excellence in research and coursework, a research proposal, a training plan, and letters of recommendation. All trainees are required to take a Scientific Ethics course, an approved slate of courses, and participate in PITCH activities, including a summer Journal Club, monthly student-only dinners to present research progress, an annual retreat, a virtual seminar series curated from participating departmental offerings, and a Nano-Sabbatical program to acquire professional experience outside of the thesis lab. Support is requested for four predoctoral students per year. The impact of this program will be amplified by including students not selected for funding in PITCH activities via an affiliate program. PITCH will prepare students for leading independent positions in Chemical Biology.

摘要化学生物学是一门跨学科的科学，需要在化学和生物学此培训补助金申请（PITCH -化学生物学跨学科培训计划）请求支持犹他州大学的跨部门化学生物学培训计划。这计划旨在扩大非常成功的生物化学计划的好处，跨学科的第一年研究生课程，培养学生从事化学/生物学研究整个PhD期间的接口。该计划包括个性化的研究培训下，来自理学院、药学院和医学院的37名教员的指导，它们非常接近。PITCH将在每个学生的家庭部门补充培训计划 (from他们获得博士学位），并提供一个共同导师，补充了主要的专业知识导师指导委员会挑选受训人员，监测他们的进展，并组织PITCH活动。 PITCH导师在化学生物学方面提供了多样化的跨学科培训环境。前瞻性博士预科生通过生物化学，化学或MD/PhD进入研究生院计划和竞争两年的PITCH支持，从第二年开始，基于竞争力的应用程序，评估卓越的研究和课程，研究建议，培训计划和推荐信。所有受训人员都必须参加科学道德课程，批准的课程，并参加PITCH活动，包括夏季杂志俱乐部，每月学生专用晚餐，以介绍研究进展，年度务虚会，虚拟研讨会系列策划从参与部门产品，和纳米休假计划，以获得专业经验在论文实验室外面每年需要资助4名博士前学生。这样做的影响该计划将通过一个附属机构将未被选中参加PITCH活动的学生包括在内程序. PITCH将为学生在化学生物学中的领导独立职位做好准备。

项目成果

期刊论文数量（7）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Intermolecular electron transfer in radical SAM enzymes as a new paradigm for reductive activation.

DOI：
10.1016/j.jbc.2023.105058
发表时间：
2023-09
期刊：
The Journal of biological chemistry
影响因子：
0
作者：
Eastman KAS;Jochimsen AS;Bandarian V
通讯作者：
Bandarian V

In vitro studies provide insight into effects of Dicer-2 helicase mutations in Drosophila melanogaster.

DOI：
10.1261/rna.077289.120
发表时间：
2020-12
期刊：
RNA (New York, N.Y.)
影响因子：
0
作者：
Donelick HM;Talide L;Bellet M;Aruscavage PJ;Lauret E;Aguiar ERGR;Marques JT;Meignin C;Bass BL
通讯作者：
Bass BL

A Promiscuous rSAM Enzyme Enables Diverse Peptide Cross-linking.

DOI：
10.1021/acsbiomedchemau.3c00043
发表时间：
2023-12-20
期刊：
ACS BIO & MED CHEM AU
影响因子：
0
作者：
Eastman, Karsten A S;Mifflin, Marcus C;Oblad, Paul F;Roberts, Andrew G;Bandarian, Vahe
通讯作者：
Bandarian, Vahe

Dicer's Helicase Domain: A Meeting Place for Regulatory Proteins.