Otolaryngology Training in Immunology, Virology and Molecular Biology

免疫学、病毒学和分子生物学的耳鼻喉科培训

• 批准号: 10426896
• 负责人: Rick A Friedman
• 金额: $ 28.17万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-07-01 至 2027-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10426896
• 关键词: Address; Area; Attention; Basic Science; Biomedical Research; Career Choice; Clinical; Clinical Research; Clinical Sciences; Collaborations; Communicable Diseases; Conflict (Psychology); Counseling; Development; Disease; Education; Education Projects; Ensure; Evidence Based Medicine; Experimental Designs; Fellowship; Female; Funding; Future; Genomic medicine; Goals; Grant; Head and neck structure; Healthcare; Immune; Immunologics; Immunology; Immunotherapy; Inflammatory; Institution; Instruction; Lead; Length; Malignant Neoplasms; Manuscripts; Mediating; Medicine; Mentors; Methods; Minority; Mission; Molecular; Molecular Biology; National Institute on Deafness and Other Communication Disorders; Natural Immunity; Otolaryngologist; Otolaryngology; Patient Care; Patients; Physicians; Play; Preparation; Public Health Education; Reproducibility; Research; Research Ethics; Research Personnel; Research Project Grants; Research Training; Residencies; Role; Science; Scientist; Structure; Supervision; Surgical Specialties; Teacher Professional Development; Techniques; Therapeutic; Time; Training; Training Programs; Translational Research; Underrepresented Populations; Virus Diseases; Wages; Work; Writing; academic preparation; career; data quality; education research; experience; medical schools; medical specialties; pathogen; programs; receptor; recruit; responsible research conduct; skills; success; symposium; virology

PROJECT SUMMARY/ABSTRACT The education of clinician-scientists is of paramount importance to the field of Otolaryngology. The need for interfaces between science and medicine, the importance of clinicians that value scientific research, and the increased importance of evidence-based medicine in health care all argue for research training of physicians. Moreover, the impact of immunological mechanisms in many ENT diseases has received increased attention in the past decade, with an increase immune/inflammatory therapeutics in our field. Immunotherapy has proven to be highly effective in several forms of cancer. Yet Otolaryngology remains behind many other areas of medicine in immunology research. As an example, the area of innate immunity mediated by pathogen receptors has seen a dramatic expansion in the broader field of immunology and infectious diseases over the past 20 years, and the head and neck represent a major pathogen interface. However, only within the last few years has an increase in innate immune research been seen in our field. The availability of molecular methods has transformed research in immunology and other areas of biomedicine, molecular therapies are in active development, and the era of genomic medicine has arrived. Clinician-scientists well trained in molecular biology are therefore needed. Finally, research into viral diseases could not be more relevant at the current time. Over the past 30 years, UCSD Otolaryngology has expanded its immunology, virology and molecular research, resulting in an established cadre of scientists. These investigators provide a fertile training ground for clinicians who wish to pursue these arenas of research, to provide ENT with well-trained clinician-scientists. We propose to continue our clinician-scientist resident research training program under the R25 mechanism. Our program addresses the major barriers to research by clinicians by providing training in: 1) experimental design and scientific techniques; 2) research collaboration and teambuilding; 3) grant and scientific manuscript writing; 4) managing the conflict between clinical work and research; and 5) preparation for academic medicine. The trainees for this program will be selected from MD's who wish to pursue eighteen months of research training during their Otolaryngology residency, consisting of the R25 year and additional periods of research training embedded in clinical training. Trainees from underrepresented groups will be actively sought. Trainees will receive advanced basic science, translational or clinical research training in the application of advanced immunology, virology and molecular biology methods to research problems within the NIDCD arena. Research training will extend throughout residency, to provide continuity and avoid a significant training gap. Trainees will also receive instruction in research ethics, methods to ensure data quality and reproducibility, responsible conduct of research, and the preparation of initial review board applications. Finally, we will encourage choice of a career including research with specific education.

项目摘要/摘要 临床医生科学家的教育对于耳鼻喉科领域至关重要。需要 科学与医学之间的接口，重视科学研究的临床医生的重要性以及 循证医学在卫生保健中的重要性都主张 医师。此外，免疫机制在许多ENT疾病中的影响已收到 在过去的十年中，人们的注意力越来越高，我们领域的免疫/炎症治疗剂会增加。 事实证明，免疫疗法在几种形式的癌症中非常有效。然而，耳鼻喉科仍然存在 免疫学研究中许多其他医学领域的背后。例如，先天免疫区域 由病原体受体介导的，在较广泛的免疫学领域和 在过去的20年中，传染病是一种主要的病原体界面。 但是，只有在过去的几年中，我们领域的先天免疫研究才增加。 分子方法的可用性改变了免疫学和其他领域的研究 生物医学，分子疗法正在积极发育，基因组医学的时代已经到来。 因此，需要经过良好训练分子生物学的临床医生。最后，对病毒的研究 目前，疾病不可能更相关。在过去的30年中，UCSD耳鼻喉科具有 扩大了其免疫学，病毒学和分子研究，导致了一群成熟的科学家干部。 这些调查人员为希望追求这些领域的临床医生提供了肥沃的培训理由 研究，为ENT提供训练有素的临床医生科学家。我们建议继续我们的临床医生科学家 R25机制下的居民研究培训计划。我们的计划解决了主要障碍 临床医生通过提供培训的研究：1）实验设计和科学技术； 2）研究 协作和团队建设； 3）赠款和科学手稿写作； 4）管理 临床工作和研究； 5）准备学术医学。该计划的学员将是 从医学博士选中，希望在耳鼻喉科期间接受18个月的研究培训 居住权，包括R25年和嵌入在临床中的其他研究培训期 训练。来自代表性不足的团体的学员将被积极寻求。学员将获得高级 高级免疫学，病毒学应用的基础科学，转化或临床研究培训 和分子生物学方法来研究NIDCD领域内的问题。研究培训将扩展 在整个驻留期间，提供连续性并避免明显的训练差距。学员也将收到 研究伦理学的指导，确保数据质量和可重复性的方法，负责任的行为 研究以及初始审查委员会申请的准备。最后，我们将鼓励选择 职业包括对特定教育的研究。