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Otolaryngology Training in Immunology, Virology and Molecular Biology

免疫学、病毒学和分子生物学的耳鼻喉科培训

基本信息

批准号：
10599353
负责人：
Rick A Friedman
金额：
$ 28.17万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN DIEGO
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-07-01 至 2027-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10599353
关键词：
Address Area Attention Basic Science Biomedical Research Career Choice Clinical Clinical Research Clinical Sciences Collaborations Communicable Diseases Conflict (Psychology)Counseling Development Disease Education Education Projects Ensure Evidence Based Medicine Experimental Designs Fellowship Female Funding Future Genomic medicine Goals Grant Head and neck structure Healthcare Immune Immunologics Immunology Immunotherapy Inflammatory Institution Instruction Length Malignant Neoplasms Manuscripts Mediating Medicine Mentors Methods Minority Mission Molecular Molecular Biology National Institute on Deafness and Other Communication Disorders Natural Immunity Otolaryngologist Otolaryngology Patient Care Patients Physicians Play Preparation Public Health Reproducibility Research Research Ethics Research Personnel Research Project Grants Research Training Residencies Role Science Scientist Structure Supervision Surgical Specialties Teacher Professional Development Techniques Therapeutic Time Training Training Programs Translational Research Underrepresented Populations Virus Diseases Wages Work Writing academic preparation career clinical training data quality education research experience medical schools medical specialties pathogen programs receptor recruit responsible research conduct skills success symposium virology

项目摘要

PROJECT SUMMARY/ABSTRACT The education of clinician-scientists is of paramount importance to the field of Otolaryngology. The need for interfaces between science and medicine, the importance of clinicians that value scientific research, and the increased importance of evidence-based medicine in health care all argue for research training of physicians. Moreover, the impact of immunological mechanisms in many ENT diseases has received increased attention in the past decade, with an increase immune/inflammatory therapeutics in our field. Immunotherapy has proven to be highly effective in several forms of cancer. Yet Otolaryngology remains behind many other areas of medicine in immunology research. As an example, the area of innate immunity mediated by pathogen receptors has seen a dramatic expansion in the broader field of immunology and infectious diseases over the past 20 years, and the head and neck represent a major pathogen interface. However, only within the last few years has an increase in innate immune research been seen in our field. The availability of molecular methods has transformed research in immunology and other areas of biomedicine, molecular therapies are in active development, and the era of genomic medicine has arrived. Clinician-scientists well trained in molecular biology are therefore needed. Finally, research into viral diseases could not be more relevant at the current time. Over the past 30 years, UCSD Otolaryngology has expanded its immunology, virology and molecular research, resulting in an established cadre of scientists. These investigators provide a fertile training ground for clinicians who wish to pursue these arenas of research, to provide ENT with well-trained clinician-scientists. We propose to continue our clinician-scientist resident research training program under the R25 mechanism. Our program addresses the major barriers to research by clinicians by providing training in: 1) experimental design and scientific techniques; 2) research collaboration and teambuilding; 3) grant and scientific manuscript writing; 4) managing the conflict between clinical work and research; and 5) preparation for academic medicine. The trainees for this program will be selected from MD's who wish to pursue eighteen months of research training during their Otolaryngology residency, consisting of the R25 year and additional periods of research training embedded in clinical training. Trainees from underrepresented groups will be actively sought. Trainees will receive advanced basic science, translational or clinical research training in the application of advanced immunology, virology and molecular biology methods to research problems within the NIDCD arena. Research training will extend throughout residency, to provide continuity and avoid a significant training gap. Trainees will also receive instruction in research ethics, methods to ensure data quality and reproducibility, responsible conduct of research, and the preparation of initial review board applications. Finally, we will encourage choice of a career including research with specific education.

项目概要/摘要临床医生科学家的教育对于耳鼻喉科领域至关重要。需要科学与医学之间的接口、重视科学研究的临床医生的重要性以及循证医学在卫生保健中的重要性日益增加，所有人都主张对以下方面进行研究培训：医生。此外，免疫机制在许多耳鼻喉疾病中的影响已经受到重视。在过去的十年中，随着我们领域的免疫/炎症治疗的增加，人们的关注度越来越高。免疫疗法已被证明对多种癌症非常有效。然而耳鼻喉科仍然免疫学研究落后于许多其他医学领域。举个例子，先天免疫领域由病原体受体介导的免疫学在更广泛的免疫学领域得到了显着的扩展过去20年的传染病中，头颈部是主要的病原体接触面。然而，直到最近几年，我们领域的先天免疫研究才有所增加。分子方法的可用性改变了免疫学和其他领域的研究生物医学、分子疗法正在积极发展，基因组医学时代已经到来。因此，需要在分子生物学方面受过良好培训的临床医生科学家。最后，对病毒的研究目前，疾病的相关性再大不过了。过去 30 年来，加州大学圣地亚哥分校耳鼻喉科扩大了免疫学、病毒学和分子研究，形成了一支成熟的科学家队伍。这些研究人员为希望从事这些领域研究的临床医生提供了肥沃的训练场地研究，为耳鼻喉科提供训练有素的临床医生科学家。我们建议继续我们的临床医生科学家 R25机制下的驻地研究培训项目。我们的计划解决了主要障碍临床医生通过提供以下方面的培训进行研究：1）实验设计和科学技术； 2）研究协作和团队建设； 3）资助和科学稿件写作； 4）管理之间的冲突临床工作和研究； 5）学术医学的准备。该计划的学员将是从希望在耳鼻喉科期间接受十八个月的研究培训的医学博士中选拔住院医师实习期，包括 R25 年和嵌入临床的额外研究培训期训练。将积极寻找来自代表性不足群体的学员。学员将获得先进的应用高级免疫学、病毒学的基础科学、转化或临床研究培训和分子生物学方法来研究 NIDCD 领域内的问题。研究培训将延长在整个住院期间，提供连续性并避免重大的培训差距。学员还将获得研究伦理、确保数据质量和可重复性的方法、负责任的行为指导研究，以及准备初步审查委员会申请。最后，我们将鼓励选择职业包括具有特定教育的研究。

项目成果

期刊论文数量（11）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

The Feasibility of Outpatient Type I Thyroplasty with Laryngeal Reinnervation.

门诊 I 型甲状腺成形术伴喉神经支配的可行性。

DOI：
10.1177/01455613221116326
发表时间：
2022
期刊：
Ear, nose, & throat journal
影响因子：
0
作者：
Ostrander,BenjaminT;Vahabzadeh-Hagh,AndrewM
通讯作者：
Vahabzadeh-Hagh,AndrewM

Endoscopic Repair of a Full Thickness Hypopharyngeal Defect Using Acellular Dermal Matrix.

使用脱细胞真皮基质内窥镜修复全层下咽缺损。

DOI：
10.1177/01455613231206293
发表时间：
2023
期刊：
Ear, nose, & throat journal
影响因子：
0
作者：
Ostrander,BenjaminT;Kolb,FredericJ;Weissbrod,PhilipA
通讯作者：
Weissbrod,PhilipA

Free flap jaw reconstruction with dental implantation: A single-institution experience.

自由瓣颌重建并种植牙：单一机构的经验。

DOI：
10.1002/hed.27683
发表时间：
2024
期刊：
Head & neck
影响因子：
0
作者：
Ostrander,BenjaminT;Meller,Leo;Harmon,Matthew;Archambault,Katya;Kristallis,Thanos;Hammer,Daniel;Orosco,RyanK
通讯作者：
Orosco,RyanK

Comparison of Postoperative Outcomes in Cystic Versus Solid Vestibular Schwannoma in a Multi-institutional Cohort.

多机构队列中囊性前庭神经鞘瘤与实性前庭神经鞘瘤术后结果的比较。

DOI：
10.1097/mao.0000000000004062
发表时间：
2024
期刊：
Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
影响因子：
0
作者：
Zhang,Lisa;Ostrander,BenjaminT;Duhon,Bailey;Moshitaghi,Omid;Lee,Joshua;Harris,Micah;Hardesty,DouglasA;Prevedello,DanielM;Schwartz,MarcS;Dodson,EdwardE;Friedman,RickA;Adunka,OliverF;Ren,Yin
通讯作者：
Ren,Yin

New Medical Device and Therapeutic Approvals in Otolaryngology: State of the Art Review of 2021.

DOI：
10.1177/2473974x221126495
发表时间：
2022-07
期刊：
OTO OPEN
影响因子：
1.5
作者：
Choi, Alexander M.;Brenner, Michael J.;Gorelik, Daniel;Erbele, Isaac D.;Crowson, Matthew G.;Kadkade, Prajoy;Takashima, Masayoshi;Santa Maria, Peter L.;Hong, Robert S.;Rose, Austin S.;Ostrander, Benjamin T.;Rabbani, Cyrus C.;Morrison, Robert J.;Weissbrod, Philip A.;Tate, Alan D.;Kain, Joshua J.;Lina, Ioan A.;Shaffer, Scott R.;Ahmed, Omar G.
通讯作者：
Ahmed, Omar G.