Otolaryngology Training in Immunology, Virology and Molecular Biology

免疫学、病毒学和分子生物学的耳鼻喉科培训

基本信息

  • 批准号:
    10599353
  • 负责人:
  • 金额:
    $ 28.17万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2022
  • 资助国家:
    美国
  • 起止时间:
    2022-07-01 至 2027-06-30
  • 项目状态:
    未结题

项目摘要

PROJECT SUMMARY/ABSTRACT The education of clinician-scientists is of paramount importance to the field of Otolaryngology. The need for interfaces between science and medicine, the importance of clinicians that value scientific research, and the increased importance of evidence-based medicine in health care all argue for research training of physicians. Moreover, the impact of immunological mechanisms in many ENT diseases has received increased attention in the past decade, with an increase immune/inflammatory therapeutics in our field. Immunotherapy has proven to be highly effective in several forms of cancer. Yet Otolaryngology remains behind many other areas of medicine in immunology research. As an example, the area of innate immunity mediated by pathogen receptors has seen a dramatic expansion in the broader field of immunology and infectious diseases over the past 20 years, and the head and neck represent a major pathogen interface. However, only within the last few years has an increase in innate immune research been seen in our field. The availability of molecular methods has transformed research in immunology and other areas of biomedicine, molecular therapies are in active development, and the era of genomic medicine has arrived. Clinician-scientists well trained in molecular biology are therefore needed. Finally, research into viral diseases could not be more relevant at the current time. Over the past 30 years, UCSD Otolaryngology has expanded its immunology, virology and molecular research, resulting in an established cadre of scientists. These investigators provide a fertile training ground for clinicians who wish to pursue these arenas of research, to provide ENT with well-trained clinician-scientists. We propose to continue our clinician-scientist resident research training program under the R25 mechanism. Our program addresses the major barriers to research by clinicians by providing training in: 1) experimental design and scientific techniques; 2) research collaboration and teambuilding; 3) grant and scientific manuscript writing; 4) managing the conflict between clinical work and research; and 5) preparation for academic medicine. The trainees for this program will be selected from MD's who wish to pursue eighteen months of research training during their Otolaryngology residency, consisting of the R25 year and additional periods of research training embedded in clinical training. Trainees from underrepresented groups will be actively sought. Trainees will receive advanced basic science, translational or clinical research training in the application of advanced immunology, virology and molecular biology methods to research problems within the NIDCD arena. Research training will extend throughout residency, to provide continuity and avoid a significant training gap. Trainees will also receive instruction in research ethics, methods to ensure data quality and reproducibility, responsible conduct of research, and the preparation of initial review board applications. Finally, we will encourage choice of a career including research with specific education.
项目概要/摘要 临床医生科学家的教育对于耳鼻喉科领域至关重要。需要 科学与医学之间的接口、重视科学研究的临床医生的重要性以及 循证医学在卫生保健中的重要性日益增加,所有人都主张对以下方面进行研究培训: 医生。此外,免疫机制在许多耳鼻喉疾病中的影响已经受到重视。 在过去的十年中,随着我们领域的免疫/炎症治疗的增加,人们的关注度越来越高。 免疫疗法已被证明对多种癌症非常有效。然而耳鼻喉科仍然 免疫学研究落后于许多其他医学领域。举个例子,先天免疫领域 由病原体受体介导的免疫学在更广泛的免疫学领域得到了显着的扩展 过去20年的传染病中,头颈部是主要的病原体接触面。 然而,直到最近几年,我们领域的先天免疫研究才有所增加。 分子方法的可用性改变了免疫学和其他领域的研究 生物医学、分子疗法正在积极发展,基因组医学时代已经到来。 因此,需要在分子生物学方面受过良好培训的临床医生科学家。最后,对病毒的研究 目前,疾病的相关性再大不过了。过去 30 年来,加州大学圣地亚哥分校耳鼻喉科 扩大了免疫学、病毒学和分子研究,形成了一支成熟的科学家队伍。 这些研究人员为希望从事这些领域研究的临床医生提供了肥沃的训练场地 研究,为耳鼻喉科提供训练有素的临床医生科学家。我们建议继续我们的临床医生科学家 R25机制下的驻地研究培训项目。我们的计划解决了主要障碍 临床医生通过提供以下方面的培训进行研究:1)实验设计和科学技术; 2)研究 协作和团队建设; 3)资助和科学稿件写作; 4)管理之间的冲突 临床工作和研究; 5)学术医学的准备。该计划的学员将是 从希望在耳鼻喉科期间接受十八个月的研究培训的医学博士中选拔 住院医师实习期,包括 R25 年和嵌入临床的额外研究培训期 训练。将积极寻找来自代表性不足群体的学员。学员将获得先进的 应用高级免疫学、病毒学的基础科学、转化或临床研究培训 和分子生物学方法来研究 NIDCD 领域内的问题。研究培训将延长 在整个住院期间,提供连续性并避免重大的培训差距。学员还将获得 研究伦理、确保数据质量和可重复性的方法、负责任的行为指导 研究,以及准备初步审查委员会申请。最后,我们将鼓励选择 职业包括具有特定教育的研究。

项目成果

期刊论文数量(11)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
The Feasibility of Outpatient Type I Thyroplasty with Laryngeal Reinnervation.
门诊 I 型甲状腺成形术伴喉神经支配的可行性。
  • DOI:
    10.1177/01455613221116326
  • 发表时间:
    2022
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Ostrander,BenjaminT;Vahabzadeh-Hagh,AndrewM
  • 通讯作者:
    Vahabzadeh-Hagh,AndrewM
Endoscopic Repair of a Full Thickness Hypopharyngeal Defect Using Acellular Dermal Matrix.
使用脱细胞真皮基质内窥镜修复全层下咽缺损。
  • DOI:
    10.1177/01455613231206293
  • 发表时间:
    2023
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Ostrander,BenjaminT;Kolb,FredericJ;Weissbrod,PhilipA
  • 通讯作者:
    Weissbrod,PhilipA
Free flap jaw reconstruction with dental implantation: A single-institution experience.
自由瓣颌重建并种植牙:单一机构的经验。
  • DOI:
    10.1002/hed.27683
  • 发表时间:
    2024
  • 期刊:
  • 影响因子:
    0
  • 作者:
    Ostrander,BenjaminT;Meller,Leo;Harmon,Matthew;Archambault,Katya;Kristallis,Thanos;Hammer,Daniel;Orosco,RyanK
  • 通讯作者:
    Orosco,RyanK
Comparison of Postoperative Outcomes in Cystic Versus Solid Vestibular Schwannoma in a Multi-institutional Cohort.
多机构队列中囊性前庭神经鞘瘤与实性前庭神经鞘瘤术后结果的比较。
New Medical Device and Therapeutic Approvals in Otolaryngology: State of the Art Review of 2021.
  • DOI:
    10.1177/2473974x221126495
  • 发表时间:
    2022-07
  • 期刊:
  • 影响因子:
    1.5
  • 作者:
    Choi, Alexander M.;Brenner, Michael J.;Gorelik, Daniel;Erbele, Isaac D.;Crowson, Matthew G.;Kadkade, Prajoy;Takashima, Masayoshi;Santa Maria, Peter L.;Hong, Robert S.;Rose, Austin S.;Ostrander, Benjamin T.;Rabbani, Cyrus C.;Morrison, Robert J.;Weissbrod, Philip A.;Tate, Alan D.;Kain, Joshua J.;Lina, Ioan A.;Shaffer, Scott R.;Ahmed, Omar G.
  • 通讯作者:
    Ahmed, Omar G.
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Rick A Friedman其他文献

Preserving hearing after sudden loss in acoustic neuroma
  • DOI:
    10.1016/s0194-5998(99)80288-5
  • 发表时间:
    1999-08-01
  • 期刊:
  • 影响因子:
  • 作者:
    Bradley W Kesser;Rick A Friedman;Derald E Brackmann;William E Hitselberger
  • 通讯作者:
    William E Hitselberger

Rick A Friedman的其他文献

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{{ truncateString('Rick A Friedman', 18)}}的其他基金

Otolaryngology Training in Immunology, Virology and Molecular Biology
免疫学、病毒学和分子生物学的耳鼻喉科培训
  • 批准号:
    10426896
  • 财政年份:
    2022
  • 资助金额:
    $ 28.17万
  • 项目类别:
Mechanisms of protection from noise-induced hearing loss
噪音引起的听力损失的保护机制
  • 批准号:
    10576822
  • 财政年份:
    2022
  • 资助金额:
    $ 28.17万
  • 项目类别:
Mechanisms of protection from noise-induced hearing loss
噪音引起的听力损失的保护机制
  • 批准号:
    10365558
  • 财政年份:
    2022
  • 资助金额:
    $ 28.17万
  • 项目类别:
The genetic basis for age-related hearing loss in outbred mice
远交小鼠年龄相关性听力损失的遗传基础
  • 批准号:
    10266167
  • 财政年份:
    2020
  • 资助金额:
    $ 28.17万
  • 项目类别:
The genetic basis for age-related hearing loss in outbred mice
远交小鼠年龄相关性听力损失的遗传基础
  • 批准号:
    10468839
  • 财政年份:
    2020
  • 资助金额:
    $ 28.17万
  • 项目类别:
The genetic basis for age-related hearing loss in outbred mice
远交小鼠年龄相关性听力损失的遗传基础
  • 批准号:
    10685625
  • 财政年份:
    2020
  • 资助金额:
    $ 28.17万
  • 项目类别:
High-Resolution Mapping of Susceptibility Genes for NIHL
NIHL 易感基因的高分辨率图谱
  • 批准号:
    8602516
  • 财政年份:
    2011
  • 资助金额:
    $ 28.17万
  • 项目类别:
High-Resolution Mapping of Susceptibility Genes for NIHL
NIHL 易感基因的高分辨率图谱
  • 批准号:
    8725407
  • 财政年份:
    2011
  • 资助金额:
    $ 28.17万
  • 项目类别:
High-Resolution Mapping of Susceptibility Genes for NIHL
NIHL 易感基因的高分辨率图谱
  • 批准号:
    8215868
  • 财政年份:
    2011
  • 资助金额:
    $ 28.17万
  • 项目类别:
High-Resolution Mapping of Susceptibility Genes for NIHL
NIHL 易感基因的高分辨率图谱
  • 批准号:
    8793777
  • 财政年份:
    2011
  • 资助金额:
    $ 28.17万
  • 项目类别:

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基于SSVEP的BCI注意力区域估计和安全性评估
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