Characterization of endovascular ablative therapies with computational modeling

超过80%的肝细胞癌患者无法获得根治性治疗 (肝细胞癌)。有一种公认的需要新的方法，可以复杂地平衡疾病的治疗 (2)保护肝功能，将复发和转移的风险降至最低。热栓子- TION为微创干预提供了一个新的概念平台，在该平台中，酸性氯化物试剂 通过血管内途径经动脉导管输送。试剂溶解在一种惰性油中。 并夹在前缘和后缘的两等份惰性溶剂之间。水解法 靶组织内的酸性氯化物同时释放母体酸和相当于hy- 氟氯酸。局部的酸释放，伴随着血液供应的中断和高温 放热反应产生的能量协同作用导致肿瘤细胞死亡。当前翻译面临的挑战 这种令人兴奋的治疗方法对患者来说是缺乏对受控分娩机制的描述。项目 工作重点是将成像测量与数学模型开发相结合，以提供关键的洞察力 在开发这一新的热栓塞治疗方法方面。使用高fi精确度预测模型将 描述控制有效气体的基本质量、热和化学传输过程 热栓塞术不会对组织造成损害。一支高度跨学科的团队，具有以下专业知识 成像物理学、数学建模、介入放射学、兽医病理学和生物化学 都是为了实现这一目标而组装的。

Curative therapies are not available to greater than 80% of the patient population with hepatocellular carcinoma (HCC). There is a well-recognized need for novel methods that can intricately balance (1) treatment of the disease extent with (2) preservation of liver function and minimizing risk of recurrence and metastasis. Thermoemboliza- tion provides a novel conceptual platform for minimally invasive interventions in which an acid chloride reagent is delivered through an endovascular route via transarterial catheter. The reagent is dissolved in an inert oily solvent and sandwiched between two aliquots of the inert solvent at the leading and trailing edges. Hydrolysis of the acid chloride within the target tissue simultaneously releases the parent acid and an equivalent of hy- drochloric acid. The localized release of acid combined with disruption of the blood supply as well as the heat energy from the exothermic reaction synergistically causes tumor cell death. Current challenges in translating this exciting therapy to patients are a lack of characterization of the mechanisms for a controlled delivery. Project efforts focus on integrating imaging measurements with mathematical model developments to provide key insight in developing this novel thermoembolization treatment approach. The use of high-fidelity predictive models will characterize fundamental mass, thermal, and chemical transport processes needed for control of an effective thermoembolization delivery without unwanted tissue damage. A highly interdisciplinary team with expertise in imaging physics, mathematical modeling, interventional radiology, veterinary pathology, and biochemistry has been assembled to accomplish this goal.