Characterization of endovascular ablative therapies with computational modeling

超过80%的肝细胞癌患者人群无法获得治愈性治疗 （HCC）。人们普遍认识到需要新的方法来复杂地平衡（1）疾病的治疗 程度与（2）保存肝功能和最大限度地减少复发和转移的风险。热栓塞- Tion为微创干预提供了一个新的概念平台，其中酰氯试剂 通过经动脉导管的血管内途径输送。将试剂溶解在惰性油状物中， 溶剂，并在前缘和后缘处夹在惰性溶剂的两个等分试样之间。水解 目标组织内的酰氯同时释放母体酸和当量的HY- 盐酸酸的局部释放加上血液供应的中断以及热量 来自放热反应的能量协同地导致肿瘤细胞死亡。当前翻译面临的挑战 这种令人兴奋的治疗对患者来说是一种缺乏表征的机制，用于控制输送。项目 工作重点是将成像测量与数学模型开发相结合， 开发这种新型热栓塞治疗方法。高精度预测模型的使用将 描述控制有效的大气污染所需的基本质量、热量和化学传输过程。 热栓塞输送，无不必要的组织损伤。一个高度跨学科的团队， 影像物理学、数学建模、介入放射学、兽医病理学和生物化学， 是为了实现这一目标。

Curative therapies are not available to greater than 80% of the patient population with hepatocellular carcinoma (HCC). There is a well-recognized need for novel methods that can intricately balance (1) treatment of the disease extent with (2) preservation of liver function and minimizing risk of recurrence and metastasis. Thermoemboliza- tion provides a novel conceptual platform for minimally invasive interventions in which an acid chloride reagent is delivered through an endovascular route via transarterial catheter. The reagent is dissolved in an inert oily solvent and sandwiched between two aliquots of the inert solvent at the leading and trailing edges. Hydrolysis of the acid chloride within the target tissue simultaneously releases the parent acid and an equivalent of hy- drochloric acid. The localized release of acid combined with disruption of the blood supply as well as the heat energy from the exothermic reaction synergistically causes tumor cell death. Current challenges in translating this exciting therapy to patients are a lack of characterization of the mechanisms for a controlled delivery. Project efforts focus on integrating imaging measurements with mathematical model developments to provide key insight in developing this novel thermoembolization treatment approach. The use of high-fidelity predictive models will characterize fundamental mass, thermal, and chemical transport processes needed for control of an effective thermoembolization delivery without unwanted tissue damage. A highly interdisciplinary team with expertise in imaging physics, mathematical modeling, interventional radiology, veterinary pathology, and biochemistry has been assembled to accomplish this goal.