Characterization of endovascular ablative therapies with computational modeling

通过计算模型表征血管内消融治疗

• 批准号: 10629321
• 负责人: David Fuentes
• 金额: $ 18.56万
• 依托单位: UNIVERSITY OF TX MD ANDERSON CAN CTR
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-05-26 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10629321
• 关键词: Ablation; Acids; Acute; Aliquot; Area; Behavior; Biochemistry; Biological; Blood flow; Bolus Infusion; Calibration; Catheters; Cell Death; Characteristics; Chemicals; Chlorides; Clinical; Computer Models; Convection; Data; Diameter; Diffusion; Disease; Environment; Equilibrium; Goals; Hydrochloric Acid; Hydrolysis; Hyperthermia; Image; Image Enhancement; Inflammation; Intervention; Interventional radiology; Intuition; Investigation; Ischemia; Left; Liver; Mathematics; Measurement; Measures; Methods; Modality; Modeling; Monitor; Neoplasm Metastasis; Outcome; Parents; Patients; Physics; Porosity; Primary carcinoma of the liver cells; Procedures; Process; Property; Protocols documentation; Reaction; Reagent; Recurrence; Reflexology; Research; Risk; Route; Solvents; Techniques; Temperature; Therapeutic Embolization; Thermal Ablation Therapy; Thermal Conductivity; Thermometry; Tissues; Translating; Transport Process; Validation; Vascular blood supply; Veterinary Pathology; Viscosity; chemical reaction; clinical translation; contrast enhanced; curative treatments; in vivo; insight; liver ablation; liver function; liver preservation; mathematical model; minimally invasive; model development; neoplastic cell; novel; novel strategies; patient population; porcine model; preclinical study; predictive modeling; pressure; prospective; quantitative imaging; risk minimization; simulation; tumor; vascular bed; virtual experiments

Curative therapies are not available to greater than 80% of the patient population with hepatocellular carcinoma (HCC). There is a well-recognized need for novel methods that can intricately balance (1) treatment of the disease extent with (2) preservation of liver function and minimizing risk of recurrence and metastasis. Thermoemboliza- tion provides a novel conceptual platform for minimally invasive interventions in which an acid chloride reagent is delivered through an endovascular route via transarterial catheter. The reagent is dissolved in an inert oily solvent and sandwiched between two aliquots of the inert solvent at the leading and trailing edges. Hydrolysis of the acid chloride within the target tissue simultaneously releases the parent acid and an equivalent of hy- drochloric acid. The localized release of acid combined with disruption of the blood supply as well as the heat energy from the exothermic reaction synergistically causes tumor cell death. Current challenges in translating this exciting therapy to patients are a lack of characterization of the mechanisms for a controlled delivery. Project efforts focus on integrating imaging measurements with mathematical model developments to provide key insight in developing this novel thermoembolization treatment approach. The use of high-fidelity predictive models will characterize fundamental mass, thermal, and chemical transport processes needed for control of an effective thermoembolization delivery without unwanted tissue damage. A highly interdisciplinary team with expertise in imaging physics, mathematical modeling, interventional radiology, veterinary pathology, and biochemistry has been assembled to accomplish this goal.

超过80%的肝细胞癌患者无法获得根治性治疗