Electrophysiological Read-Out of Interoceptive Processing in the Insula

岛叶内感受处理的电生理读数

• 批准号: 10426540
• 负责人: Allison Candice Waters
• 金额: $ 24.8万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10426540
• 关键词: Affective; Anxiety; Arousal; Attention; Behavior; Behavioral; Biofeedback Training; Blood Pressure; Brain; Breathing; Cardiac; Characteristics; Chest; Clinical; Clinical Research; Cognitive; Cues; Data; Decision Making; Diffuse; Disease; Distress; Electroencephalography; Electrophysiology (science); Epilepsy; Esthesia; Evoked Potentials; Feeling; Foundations; Frequencies; Future; Gambling; Generations; Gilles de la Tourette syndrome; Goals; Heart; Informal Social Control; Insula of Reil; Interoception; Interruption; Intervention; Investigation; Knowledge; Learning; Link; Major Depressive Disorder; Measurement; Measures; Mental Depression; Mental disorders; Modeling; Monitor; Motor; Neurologic; Obsessive-Compulsive Disorder; Outcome; Outcome Study; Patients; Pattern; Performance; Physiological; Play; Population; Pressoreceptors; Prevalence; Property; Psychometrics; Regulation; Reporting; Research; Research Domain Criteria; Rewards; Role; Scalp structure; Signal Transduction; Source; Stimulus; Surface; Symptoms; Testing; Time; addiction; base; compulsion; craving; experience; heart function; heart rate variability; indexing; insight; learned behavior; maladaptive behavior; negative mood; neural implant; neural model; neural network; neuromechanism; neuroregulation; novel; novel strategies; pressure; prevent; relating to nervous system; response; theories; tool; tool development

Project Summary / Abstract Abnormal interoceptive processing is observed across psychiatric and neurological conditions wherein core symptoms are motivated by diffuse bodily feeling: pervasive negative mood in Major Depression, compulsive urge in Obsessive Compulsive Disorder, urge to tic in Tourette Syndrome, and craving in addiction. Despite the prevalence of interoceptive abnormality, there is a scarcity of data on neurovisceral interactions in clinical populations. This knowledge gap can be attributed in part to a need for objective, neural measures of interoceptive processing. A candidate neural measure is the heartbeat evoked potential (HEP), a brain electrophysiological signal that is time-locked to the heartbeat and thought to index baroreceptor sensation in the chest cavity. While promising, basic characteristics of this signal are unknown, which limits its application to mechanistic and clinical research. Cortical sources of the HEP have been identified in the insula, yet spatial and temporal characteristics diverge across experimental paradigms. This suggests multiple functional correlates and cortical sources of the HEP index, including the insula. An added challenge is that the insula may be too deep for non-invasive recording and modulation, which necessitates invasive neural recording to explain non-invasive measures. Aim 1 validates neural source generators of the HEP with simultaneous invasive stereoelectroencephalography and dense array EEG on the scalp surface, while patients complete a battery of interoceptive tasks. Aim 2 investigates neural network dynamics during interoceptive attention, arousal and anticipation: theorizing that key clinical symptoms (e.g., tic, compulsions, negative mood) are learned behaviors in response to interoceptive cues, we test the specific hypothesis that interoceptive activity is a predictor of reward-based decisions, particularly when decision-making demands a go with your gut strategy as reward outcomes are learned. Critically, Aim 3 then applies a deep breathing strategy to strategically perturb cardiac dynamics and disambiguate functional correlates of the HEP signal. Outcomes define properties of the HEP signal that must be known for this measurement strategy to inform and validate models of abnormal interoceptive circuit dynamics involving maladaptive responses to bodily distress.

项目概要/摘要 在精神科和神经科疾病中观察到异常的内感受处理，其中核心 症状是由分散的身体感觉引起的：重度抑郁症中普遍存在的负面情绪、强迫症 强迫症中的冲动、抽动秽语综合症中的抽动冲动以及成瘾中的渴望。尽管 由于内感受异常的普遍存在，临床上缺乏神经内脏相互作用的数据 人口。这种知识差距可以部分归因于需要客观的神经测量 内感受加工。一种候选的神经测量方法是心跳诱发电位 (HEP)，即大脑 与心跳时间锁定的电生理信号，被认为可以指示压力感受器的感觉 胸腔。虽然很有希望，但该信号的基本特征尚不清楚，这限制了其应用 机制和临床研究。 HEP 的皮层来源已在岛叶中被发现，但空间 不同实验范式的时间特征有所不同。这表明多功能 HEP 指数与皮质来源（包括岛叶）相关。另一个挑战是岛叶 对于非侵入性记录和调制来说可能太深，这需要侵入性神经记录 解释非侵入性措施。目标 1 验证 HEP 的神经源生成器，同时 在头皮表面进行侵入式立体脑电图和密集阵列脑电图，同时患者完成 一系列内感受任务。目标 2 研究内感受注意力期间的神经网络动力学， 唤醒和预期：理论认为关键的临床症状（例如抽动、强迫、消极情绪）是 为了响应内感受线索而学习的行为，我们测试了内感受活动的具体假设 是基于奖励的决策的预测因素，特别是当决策需要凭直觉进行时 学习奖励结果时的策略。至关重要的是，目标 3 然后应用深呼吸策略 战略性地扰乱心脏动力学并消除 HEP 信号的功能相关性的歧义。结果 定义此测量策略必须了解的 HEP 信号的属性，以通知和验证 异常内感受回路动力学模型，涉及对身体不适的适应不良反应。