权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Electrophysiological Read-Out of Interoceptive Processing in the Insula

岛叶内感受处理的电生理读数

基本信息

批准号：
10426540
负责人：
Allison Candice Waters
金额：
$ 24.8万
依托单位：
ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-04-01 至 2024-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10426540
关键词：
Affective Anxiety Arousal Attention Behavior Behavioral Biofeedback Training Blood Pressure Brain Breathing Cardiac Characteristics Chest Clinical Clinical Research Cognitive Cues Data Decision Making Diffuse Disease Distress Electroencephalography Electrophysiology (science)Epilepsy Esthesia Evoked Potentials Feeling Foundations Frequencies Future Gambling Generations Gilles de la Tourette syndrome Goals Heart Informal Social Control Insula of Reil Interoception Interruption Intervention Investigation Knowledge Learning Link Major Depressive Disorder Measurement Measures Mental Depression Mental disorders Modeling Monitor Motor Neurologic Obsessive-Compulsive Disorder Outcome Outcome Study Patients Pattern Performance Physiological Play Population Pressoreceptors Prevalence Property Psychometrics Regulation Reporting Research Research Domain Criteria Rewards Role Scalp structure Signal Transduction Source Stimulus Surface Symptoms Testing Time addiction base compulsion craving experience heart function heart rate variability indexing insight learned behavior maladaptive behavior negative mood neural implant neural model neural network neuromechanism neuroregulation novel novel strategies pressure prevent relating to nervous system response theories tool tool development

项目摘要

Project Summary / Abstract Abnormal interoceptive processing is observed across psychiatric and neurological conditions wherein core symptoms are motivated by diffuse bodily feeling: pervasive negative mood in Major Depression, compulsive urge in Obsessive Compulsive Disorder, urge to tic in Tourette Syndrome, and craving in addiction. Despite the prevalence of interoceptive abnormality, there is a scarcity of data on neurovisceral interactions in clinical populations. This knowledge gap can be attributed in part to a need for objective, neural measures of interoceptive processing. A candidate neural measure is the heartbeat evoked potential (HEP), a brain electrophysiological signal that is time-locked to the heartbeat and thought to index baroreceptor sensation in the chest cavity. While promising, basic characteristics of this signal are unknown, which limits its application to mechanistic and clinical research. Cortical sources of the HEP have been identified in the insula, yet spatial and temporal characteristics diverge across experimental paradigms. This suggests multiple functional correlates and cortical sources of the HEP index, including the insula. An added challenge is that the insula may be too deep for non-invasive recording and modulation, which necessitates invasive neural recording to explain non-invasive measures. Aim 1 validates neural source generators of the HEP with simultaneous invasive stereoelectroencephalography and dense array EEG on the scalp surface, while patients complete a battery of interoceptive tasks. Aim 2 investigates neural network dynamics during interoceptive attention, arousal and anticipation: theorizing that key clinical symptoms (e.g., tic, compulsions, negative mood) are learned behaviors in response to interoceptive cues, we test the specific hypothesis that interoceptive activity is a predictor of reward-based decisions, particularly when decision-making demands a go with your gut strategy as reward outcomes are learned. Critically, Aim 3 then applies a deep breathing strategy to strategically perturb cardiac dynamics and disambiguate functional correlates of the HEP signal. Outcomes define properties of the HEP signal that must be known for this measurement strategy to inform and validate models of abnormal interoceptive circuit dynamics involving maladaptive responses to bodily distress.

项目摘要/摘要