Electrophysiological Read-Out of Interoceptive Processing in the Insula

项目概要/摘要 在精神和神经病症中观察到异常的内感受性处理，其中核心 症状是由弥漫性身体感觉引起的：重度抑郁症中普遍的消极情绪，强迫性 强迫症中的冲动，图雷特综合征中的抽搐冲动，以及成瘾中的渴望。尽管 内感受性异常的患病率，在临床中缺乏关于神经内脏相互作用的数据。 人口。这种知识差距可以部分归因于需要客观的，神经的措施， 内感受加工候选神经测量是心跳诱发电位（HEP），即脑电测量。 时间锁定到心跳的电生理信号，并被认为是压力感受器感觉的指标， 胸腔虽然有希望，但该信号的基本特征是未知的，这限制了其应用于 机制和临床研究。HEP的皮质来源已经在大脑中被确定，但空间上 和时间特征在实验范式中存在差异。这表明多功能 HEP指数的相关性和皮质来源，包括脑皮层。另一个挑战是， 对于非侵入性记录和调制来说可能太深，这需要侵入性神经记录， 解释非侵入性措施。目标1验证HEP的神经源发生器， 侵入性立体脑电图和密集阵列脑电图在头皮表面，而患者完成一个 一系列的内感受任务。目的2研究内感受性注意过程中的神经网络动力学， 唤醒和预期：理论上关键的临床症状（例如，抽搐，强迫症，消极情绪）是 学习行为的反应内感受性线索，我们测试的具体假设，内感受性活动 是基于奖励的决策的预测器，特别是当决策需要跟随你的直觉时 作为奖励结果的策略是学习的。关键的是，目标3然后应用深呼吸策略， 策略性地扰乱心脏动力学并消除HEP信号的功能相关性。成果 定义HEP信号的属性，这些属性对于该测量策略必须是已知的，以通知和验证 异常内感受回路动力学模型，涉及对身体痛苦的适应不良反应。

Project Summary / Abstract Abnormal interoceptive processing is observed across psychiatric and neurological conditions wherein core symptoms are motivated by diffuse bodily feeling: pervasive negative mood in Major Depression, compulsive urge in Obsessive Compulsive Disorder, urge to tic in Tourette Syndrome, and craving in addiction. Despite the prevalence of interoceptive abnormality, there is a scarcity of data on neurovisceral interactions in clinical populations. This knowledge gap can be attributed in part to a need for objective, neural measures of interoceptive processing. A candidate neural measure is the heartbeat evoked potential (HEP), a brain electrophysiological signal that is time-locked to the heartbeat and thought to index baroreceptor sensation in the chest cavity. While promising, basic characteristics of this signal are unknown, which limits its application to mechanistic and clinical research. Cortical sources of the HEP have been identified in the insula, yet spatial and temporal characteristics diverge across experimental paradigms. This suggests multiple functional correlates and cortical sources of the HEP index, including the insula. An added challenge is that the insula may be too deep for non-invasive recording and modulation, which necessitates invasive neural recording to explain non-invasive measures. Aim 1 validates neural source generators of the HEP with simultaneous invasive stereoelectroencephalography and dense array EEG on the scalp surface, while patients complete a battery of interoceptive tasks. Aim 2 investigates neural network dynamics during interoceptive attention, arousal and anticipation: theorizing that key clinical symptoms (e.g., tic, compulsions, negative mood) are learned behaviors in response to interoceptive cues, we test the specific hypothesis that interoceptive activity is a predictor of reward-based decisions, particularly when decision-making demands a go with your gut strategy as reward outcomes are learned. Critically, Aim 3 then applies a deep breathing strategy to strategically perturb cardiac dynamics and disambiguate functional correlates of the HEP signal. Outcomes define properties of the HEP signal that must be known for this measurement strategy to inform and validate models of abnormal interoceptive circuit dynamics involving maladaptive responses to bodily distress.