Effect of Mood on Cognition: A Neuropsychometric Approach to Brain Imaging

描述（由申请人提供）：拟议研究的目标是更好地理解自我评价认知中情绪约束的大脑机制。我们提出了一种新的神经心理测量方法，该方法试图将心理测量（即情绪状态测量）的优势与时间敏感性密集阵列脑电图（dEEG）相结合。我们还利用dEEG源分析的进展，以便将神经解剖学的发现背景化。这种方法不仅有助于解释结果，也使我们能够更直接地测试临床神经科学文献中提出的情感和认知大脑过程模型。情绪的二维模型（积极情绪和消极情绪）有望解释与自我评价认知相关的背-内侧和腹侧皮质网络的大脑活动差异。神经心理测量方法利用单字描述符的心理测量特性（例如，calm）来放大与积极情感相关的dEEG的方差

DESCRIPTION (provided by applicant): The goal of the proposed research is to better understand the brain mechanisms that underlie mood constraints on self-evaluative cognition. We propose a novel neuropsychometric approach to this study that attempts to merge the strengths of psychometric measurement (i.e., measurement of mood state) with the temporal sensitivity dense array electroencephalography (dEEG). We also utilize advances in dEEG source analysis in order to contextualize findings in neuroanatomy. This methodology not only aids in the interpretation of results by also enables us to more directly test models of affective and cognitive brain processes that have been suggest in the clinical neuroscience literature. A two-dimensional model of mood (Positive Affect and Negative Affect) is expected to explain differential brain activity in dorsal-medial and ventral-lateral cortical networks related to self-evaluative cognition. The neuropsychometric approach utilizes psychometric properties of single-word descriptors (e.g., calm) to amplify variance in dEEG that is related to Positive Affect or Negative Affect. A weighting statistic is derived for each descriptor item that describes the extent to which the item is associated with the psychometric scale of interest. During brain imaging, healthy, adult participants evaluate the extent to which each word is self- descriptive. Single trials of dEEG are then weighted according to the descriptor's association with PA and NA, respectively. Averaged data is expected to reflect the central tendency of the psychometric dimensions in neural indices of self-evaluative cognition. Modeled neural source activity will be used to test a model of brain function associated with maladaptive self-evaluation (i.e. depression). This research program is designed to assist the candidate's progress in the early stages of an academic research career. The candidate seeks to better understand the brain basis of psychopathology, and subsequently employ this knowledge in the development and measurement of increasingly efficacious treatments for mood-based psychological disorders.