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National Center for Quantitative Biology of Complex Systems

国家复杂系统定量生物学中心

基本信息

批准号：
10426382
负责人：
JOSHUA J COON
金额：
$ 5.75万
依托单位：
UNIVERSITY OF WISCONSIN-MADISON
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-07-05 至 2026-06-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10426382
关键词：
Address Adoption Advisory Committees Bioinformatics Biology Chemicals Collaborations Communities Complex Complex Mixtures Conflict (Psychology)Data Disputes Effectiveness Ensure Faculty Goals Individual Infrastructure Institutes Intellectual Property Label Lead Leadership Mass Spectrum Analysis Methodology Michigan Molds Molecular Biology New Acceptors Policies Procedures Process Proteins Proteomics Protocols documentation Research Research Personnel Resources Role Scanning Schedule Scientist Services Structure Suggestion System Techniques Technology Training Training Programs United States National Institutes of Health Universities Update Vision Voting Work base community engagement design experience falls frontier instrumentation interest meetings member multiple omics novel operation organizational structure recruit skills success technological innovation tool web site

项目摘要

PROJECT SUMMARY – ADMINISTRATION AND MANAGEMENT Our administrative infrastructure has been molded to meet the needs of the NCQBCS as it stands today. All Co- Investigators have been recruited by Resource PI Coon to fulfill the scientific and technical needs of the Resource. Co-Investigators Pagliarini and Li, both part of Cycle 1, will continue their commitment to the NCQBCS’s work. Our TR&Ds and DBPs have been organized to take advantage of the expertise of the investigators. Dr. Pagliarini, with assistance from Dr. Katie Overymyer, will continue to lead the DBPs. Pagliarini has an extensive background in chemical and molecular biology. Overmyer is a classically trained biochemist who has recently joined our staff. Prof. Li is recognized as a leader in chemical labeling strategies for quantitative proteomics using mass spectrometry and is therefore a natural fit for TR&D 2, which focuses on developing enhanced tagging technologies for protein quantification. In Cycle 2, we are excited to announce that we will be bringing in Prof. Robert Kennedy, University of Michigan, to provide cutting-edge separations technology needed to advance the multi-omics component of our scientific aims. Therefore, our established procedures will be modified to ensure proper integration of an off-sight Co-Investigator into the Resource. Prof. Kennedy’s expertise makes him the ideal lead for TR&D 3, directed toward integrated multi-omics. PI Coon brings extensive experience in instrumentation, training, and leadership, making him the perfect fit as the PI of the Resource and lead of TR&D 1 on biomolecule characterization. Although each investigator has responsibility for direction and lead on an individual component, no TR&D or DBP can be successfully carried out on their own. They are neither disparate projects nor research interests that simply happen to fall under the same thematic umbrella. In fact, they are by design integrative with collaborative interaction between the Co-I’s across the TR&D projects. Figure 3. NCQBCS organizational chart. Note this is structure is largely unchanged from Cycle 1.

项目摘要-行政和管理我们的行政基础设施已被塑造，以满足NCQBCS的需要，因为它是今天。所有Co- Resource PI Coon招募了研究者，以满足研究者的科学和技术需求。 Resource.共同研究者Pagliarini和Li都是第1周期的一部分，他们将继续致力于 NCQBCS的工作。我们的TR& D和DBP已经组织起来，以利用 investigators. Pagliarini博士在Katie Overymyer博士的协助下，将继续领导DBP。帕利亚里尼拥有丰富的化学和分子生物学背景。Overmyer是一个受过传统训练的生物化学家他最近加入了我们的工作。李教授被公认为定量化学标记策略的领导者。蛋白质组学使用质谱，因此是一个自然适合TR&D 2，重点是开发用于蛋白质定量的增强标记技术。在第二周期，我们很高兴地宣布，我们将引进密歇根大学罗伯特·肯尼迪教授，提供所需的尖端分离技术来推进我们科学目标中的多组学部分。因此，我们的既定程序将进行修改，以确保将视线外的联合研究者正确整合到资源中。肯尼迪教授的专业知识使他成为TR&D 3的理想领导者，致力于整合多组学。PI Coon带来了广泛的在仪器、培训和领导力方面的经验，使他成为资源和领导力的PI的完美人选领导TR&D 1生物分子表征。虽然每个调查员都有责任指导和由于在单个组件上进行了引导，因此没有TR&D或DBP可以单独成功地进行。他们既不是不同的项目或研究兴趣，只是碰巧落在同一个主题伞。事实上，通过设计，它们与跨TR&D项目的Co-I之间的协作互动相结合。图3. NCQBCS组织结构图。注意这是结构与第一周期基本相同。