National Center for Quantitative Biology of Complex Systems

项目总结--行政和管理 我们的行政基础设施已经被塑造，以满足今天NCQBCS的需要。所有的合作- 资源皮孔已经招募了调查人员，以满足 资源。共同调查员帕利亚里尼和李都是第一周期的一部分，他们将继续致力于 NCQBCS的工作。我们的研发人员和DBP已被组织起来，以利用 调查人员。Pagliarini博士将在Katie Overymyer博士的协助下继续领导DBP。帕利亚里尼 在化学和分子生物学方面有广泛的背景。奥弗迈尔是一位受过古典训练的生物化学家。 他最近加入了我们的员工队伍。李教授是公认的定量化学标记策略的领导者。 蛋白质组学使用质谱学，因此是一个天然适合的研发2，专注于开发 用于蛋白质定量的增强标记技术。在第二周期中，我们很兴奋地宣布，我们将 引入密歇根大学的罗伯特·肯尼迪教授，提供所需的尖端分离技术 以推进我们科学目标中的多组学组成部分。因此，我们的既定程序将是 修改以确保将一名非现场协查人员适当地整合到资源中。肯尼迪教授的专业知识 使他成为研发3的理想领导者，致力于整合多组学。Pi Coon带来了广泛的 在乐器、培训和领导方面的经验，使他成为资源和 R&D 1在生物分子表征上的领先。尽管每个调查员都有责任指导和 在单个部件上，没有任何研发或DBP能够单独成功地进行。他们都不是 完全不同的项目或研究兴趣，只是碰巧属于同一主题的保护伞。事实上, 它们在设计上是与研发项目中的Co-I之间的协作互动相结合的。 图3.NCQBCS组织结构图请注意，这是 结构在很大程度上与第一周期没有变化。

PROJECT SUMMARY – ADMINISTRATION AND MANAGEMENT Our administrative infrastructure has been molded to meet the needs of the NCQBCS as it stands today. All Co- Investigators have been recruited by Resource PI Coon to fulfill the scientific and technical needs of the Resource. Co-Investigators Pagliarini and Li, both part of Cycle 1, will continue their commitment to the NCQBCS’s work. Our TR&Ds and DBPs have been organized to take advantage of the expertise of the investigators. Dr. Pagliarini, with assistance from Dr. Katie Overymyer, will continue to lead the DBPs. Pagliarini has an extensive background in chemical and molecular biology. Overmyer is a classically trained biochemist who has recently joined our staff. Prof. Li is recognized as a leader in chemical labeling strategies for quantitative proteomics using mass spectrometry and is therefore a natural fit for TR&D 2, which focuses on developing enhanced tagging technologies for protein quantification. In Cycle 2, we are excited to announce that we will be bringing in Prof. Robert Kennedy, University of Michigan, to provide cutting-edge separations technology needed to advance the multi-omics component of our scientific aims. Therefore, our established procedures will be modified to ensure proper integration of an off-sight Co-Investigator into the Resource. Prof. Kennedy’s expertise makes him the ideal lead for TR&D 3, directed toward integrated multi-omics. PI Coon brings extensive experience in instrumentation, training, and leadership, making him the perfect fit as the PI of the Resource and lead of TR&D 1 on biomolecule characterization. Although each investigator has responsibility for direction and lead on an individual component, no TR&D or DBP can be successfully carried out on their own. They are neither disparate projects nor research interests that simply happen to fall under the same thematic umbrella. In fact, they are by design integrative with collaborative interaction between the Co-I’s across the TR&D projects. Figure 3. NCQBCS organizational chart. Note this is structure is largely unchanged from Cycle 1.