Building Interdisciplinary Research Careers in Women's Health

摘要 Vanderbilt-Meharry BIRCWH计划旨在增加准备充分的专职调查员队伍 通过性和性别生物学的进步来扩大对女性健康的了解。我们的学者进行 跨五个具有非凡机构实力的主题领域的研究，强调五种方法 为女童和妇女实施个性化预防、诊断和治疗的方法。 利用卓越研究的传统，学者们可以接触到许多正在进行的队列研究 方法，我们所有主题领域的现有跨学科单位，以及大规模的临床和人口- 与DNA和生物制品有关的水平数据，包括著名的财团。这种环境创造了协同效应 用于强大的机械和治疗研究，以实现实验室内外的发现。我们的36岁 以前和现在的学者进行了各种各样的研究，包括狼疮的免疫学和遗传学方面的研究，性别 重症监护病房护理结果的差异，阿尔茨海默氏症恢复力的性别差异，以及性别的作用 激素与T细胞分化和细胞因子在哮喘发病和严重程度中的表达。学者占81% 女性和28%的人认同少数民族种族/民族、性取向或历史上的弱势地位 在研究中代表性不足。几乎所有人都仍在研究中。在培训期间，学者们平均每年发表8篇论文 去年，校友们获得了107笔校外补助金，总额超过5000万美元。BIRCWH学者 以女性健康和性别差异的基本研究为基础，准备领导合作 团队，经过培训，有效地部署创新的跨学科方法来攻击和解决问题，以及 致力于研究优化所有女性的健康。学者是由竞争对手选出的 审查来自早期职业教师的申请。培训是为个别学者量身定做的，由 有组织的跨学科指导，由三名前BIRCWH联合PI监督 学者。计划资源由无数机构资源进一步扩展，确保我们的 研究人员兴旺发达。学者们组成一个指导小组，参加每周一次的BIRCWH工作进展会议 和研讨会，每年接受两次正式评估，每月参加两次职业发展研讨会系列 与其他K奖获得者合作，并定期接触到关于严格和负责任的行为的案例研究 可重复的研究。他们可以访问：1)一系列核心；2)生物统计学咨询；3)手稿 准备小组；4)成品的技术编辑；5)由专家组成的工作室，以审查科学思想， 目标、研究设计；6)校内试点资金；7)赠款编写支助，包括赠款讲习班、 资助赠款资料库和内部研究部分；以及8)新的专家咨询，以全面设计 个性化的培训计划称为路径。我们部署评估工具以不断增强我们的 由咨询委员会和网站访问者监督的计划。结合在一起，这确保了我们谨慎地 在下一代妇女健康研究人员中支持卓越和建立多样性。

ABSTRACT The Vanderbilt-Meharry BIRCWH Program seeks to increase the pool of well-prepared investigators dedicated to expanding knowledge about women's health via advances in sex and gender biology. Our scholars conduct research across five thematic areas of exceptional institutional strength emphasizing five methodologic approaches to actualize personalized prevention, diagnostics, and therapeutics for girls and women. Leveraging a tradition of research excellence, scholars have access to many ongoing cohorts taking a lifespan approach, existing interdisciplinary units in all of our thematic areas, and large-scale clinical and population- level data linked to DNA and biospecimens, including prominent consortia. This environment creates synergy for robust mechanistic and therapeutic research to deliver discoveries both inside and outside the lab. Our 36 former and current scholars conduct research as varied as immunologic and genetic aspects of lupus, gender differences in outcomes of intensive care unit care, sex differences in resilience to Alzheimer's, and role of sex hormones in T cell differentiation and cytokine expression in asthma onset and severity. Scholars are 81% women and 28% identify with minority race/ethnicity, sexual orientation, or disadvantaged status historically underrepresented in research. Nearly all remain in research. During training, scholars average 8 publications a year, and alumni have been awarded 107 extramural grants worth over $50 million total. BIRCWH Scholars are grounded in fundamentals of women's health and sex differences research, prepared to lead collaborative teams, trained to effectively deploy innovative interdisciplinary approaches to attack and solve problems, and committed to pursuing research that optimizes the health of all women. Scholars are selected by competitive review of applications from early career faculty. Training is tailored to the individual scholar guided by structured interdisciplinary mentorship and is overseen by a trio of Co-PIs who are all former BIRCWH Scholars. Program resources are further extended by myriad institutional resources that ensure our researchers thrive. Scholars form a mentoring panel, participate in weekly BIRCWH work-in-progress sessions and seminars, receive formal evaluation twice a year, attend twice-monthly career development seminar series with other K-awardees, and are regularly exposed to case studies on responsible conduct of rigorous and reproducible research. They have access to: 1) an array of cores; 2) biostatistics consults; 3) manuscript preparation groups; 4) technical editing of completed products; 5) studios with experts to vet scientific ideas, aims, and research designs; 6) intramural pilot funding; 7) grant writing support including grant workshops, a library of funded grants, and internal study sections; and 8) new expert consultations to design fully individualized training plans termed Pathways. We deploy evaluation tools to continuously enhance our program with oversight by an advisory committee and site visitors. Combined, this ensures we carefully support excellence and build diversity in the next generation of women's health researchers.