Building Interdisciplinary Research Careers in Women's Health

建立女性健康领域的跨学科研究职业

• 批准号: 10425633
• 负责人: KATHERINE E HARTMANN
• 金额: $ 61.02万
• 依托单位: VANDERBILT UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-26 至 2027-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10425633
• 关键词: Advisory Committees; Alzheimer' s Disease; Area; Asthma; Award; Biology; Biometry; Caring; Case Study; Clinical; Consult; Consultations; DNA; Data; Diagnostic; Disadvantaged; Educational workshop; Ensure; Environment; Ethnic Origin; Evaluation; Exposure to; Extramural Activities; Funding; Gender; Genetic; Gonadal Steroid Hormones; Grant; Health; Immunologics; Individual; Intensive Care Units; Interdisciplinary Study; Knowledge; Lead; Libraries; Link; Longevity; Lupus; Manuscripts; Mentors; Mentorship; Methodology; Minority; Outcome; Pathway interactions; Population; Preparation; Problem Solving; Publications; Race; Reproducibility; Research; Research Design; Research Personnel; Resources; Role; Section 8; Series; Severities; Sex Differences; Sex Orientation; Site; Structure; Study Section; T cell differentiation; Therapeutic; Therapeutic Human Experimentation; Training; Woman; Women' s Health; Writing; career; career development; cohort; cytokine; design; early-career faculty; gender difference; girls; health difference; individualized prevention; innovation; interdisciplinary approach; next generation; programs; resilience; sex; synergism; tool

ABSTRACT The Vanderbilt-Meharry BIRCWH Program seeks to increase the pool of well-prepared investigators dedicated to expanding knowledge about women's health via advances in sex and gender biology. Our scholars conduct research across five thematic areas of exceptional institutional strength emphasizing five methodologic approaches to actualize personalized prevention, diagnostics, and therapeutics for girls and women. Leveraging a tradition of research excellence, scholars have access to many ongoing cohorts taking a lifespan approach, existing interdisciplinary units in all of our thematic areas, and large-scale clinical and population- level data linked to DNA and biospecimens, including prominent consortia. This environment creates synergy for robust mechanistic and therapeutic research to deliver discoveries both inside and outside the lab. Our 36 former and current scholars conduct research as varied as immunologic and genetic aspects of lupus, gender differences in outcomes of intensive care unit care, sex differences in resilience to Alzheimer's, and role of sex hormones in T cell differentiation and cytokine expression in asthma onset and severity. Scholars are 81% women and 28% identify with minority race/ethnicity, sexual orientation, or disadvantaged status historically underrepresented in research. Nearly all remain in research. During training, scholars average 8 publications a year, and alumni have been awarded 107 extramural grants worth over $50 million total. BIRCWH Scholars are grounded in fundamentals of women's health and sex differences research, prepared to lead collaborative teams, trained to effectively deploy innovative interdisciplinary approaches to attack and solve problems, and committed to pursuing research that optimizes the health of all women. Scholars are selected by competitive review of applications from early career faculty. Training is tailored to the individual scholar guided by structured interdisciplinary mentorship and is overseen by a trio of Co-PIs who are all former BIRCWH Scholars. Program resources are further extended by myriad institutional resources that ensure our researchers thrive. Scholars form a mentoring panel, participate in weekly BIRCWH work-in-progress sessions and seminars, receive formal evaluation twice a year, attend twice-monthly career development seminar series with other K-awardees, and are regularly exposed to case studies on responsible conduct of rigorous and reproducible research. They have access to: 1) an array of cores; 2) biostatistics consults; 3) manuscript preparation groups; 4) technical editing of completed products; 5) studios with experts to vet scientific ideas, aims, and research designs; 6) intramural pilot funding; 7) grant writing support including grant workshops, a library of funded grants, and internal study sections; and 8) new expert consultations to design fully individualized training plans termed Pathways. We deploy evaluation tools to continuously enhance our program with oversight by an advisory committee and site visitors. Combined, this ensures we carefully support excellence and build diversity in the next generation of women's health researchers.

摘要 Vanderbilt-Meharry BIRCWH计划旨在增加准备充分的调查人员， 通过性和性别生物学的进步来扩大对妇女健康的认识。我们的学者进行 研究跨越五个专题领域的特殊机构实力，强调五种方法 为女孩和妇女实施个性化预防、诊断和治疗的方法。 利用卓越的研究传统，学者们可以访问许多正在进行的队列， 方法，在我们所有的主题领域现有的跨学科单位，以及大规模的临床和人口- 与DNA和生物标本相关的水平数据，包括著名的财团。这种环境创造了协同效应 用于强大的机制和治疗研究，以在实验室内外提供发现。我们的36 以前和现在的学者进行的研究，如免疫和遗传方面的狼疮，性别， 重症监护室治疗结果的差异，对阿尔茨海默病的恢复力的性别差异，以及性别的作用 激素在T细胞分化和细胞因子表达中的作用学者占81% 女性和28%的人认为自己是少数种族/民族、性取向或历史上的弱势地位 在研究中被低估。几乎所有人都在研究中。在培训期间，学者平均每年发表8篇论文， 年内，校友共获得107项校外赠款，总值超过5，000万元。BIRCWH学者 立足于妇女健康和性别差异研究的基础，准备领导合作 团队，经过培训，能够有效地部署创新的跨学科方法来解决问题， 致力于追求优化所有女性健康的研究。学者是通过竞争选拔出来的。 对早期职业教师的申请进行审查。培训是针对个别学者的指导下， 结构化的跨学科指导，并由三名共同PI监督，他们都是前BIRCWH 学者计划资源通过无数的机构资源进一步扩展，以确保我们的 研究人员茁壮成长。学者们组成一个指导小组，参加每周一次的BIRCWH工作进展会议 和研讨会，每年接受两次正式评估，参加每月两次的职业发展系列研讨会 与其他K-获奖者，并定期接触案例研究，对负责任的行为，严格和 可复制的研究他们可以获得：1）一系列核心; 2）生物统计学咨询; 3）手稿 准备小组; 4）完成产品的技术编辑; 5）专家审查科学思想的工作室， 目的和研究设计; 6）校内试点资金; 7）赠款写作支持，包括赠款讲习班， 资助赠款图书馆和内部研究部门;以及8）新的专家咨询，以充分设计 个性化的培训计划称为路径。我们部署评估工具，以不断提高我们的 由咨询委员会和网站访问者监督的程序。结合起来，这确保我们仔细 支持下一代女性健康研究人员的卓越表现并建立多样性。