Multimodality PET/CT Scanner for Small Animal Imaging

项目概要/摘要 该提案的目标是为一种专用于小动物体内成像的仪器获得资金 通过集成正电子发射断层扫描（PET）/X射线计算机断层扫描建立人类疾病模型 （CT）。我们提出的仪器是由Sofie Biosciences Inc.制造的GNEXT PET/CT系统。的 PET组件为小动物分子检测提供了高分辨率、高灵敏度和多功能平台 显像CT组件是一种快速、高分辨率的系统，可对解剖结构进行连续扫描 以及PET分子成像。该系统将取代过时的独立PET和CT扫描仪 制造商不再支持这些产品，并且某些关键组件不再 available.缺乏对这些现有扫描仪的支持是广泛的临床前 在我们的研究机构进行成像研究。PET/CT扫描仪将安装在加州大学戴维斯分校分子生物学中心， 和基因组成像（CMGI），这是校园指定和支持的核心设施，提供基础设施 和专业知识进行小动物模型的体内成像研究。CMGI负责监督回旋加速器， 放射化学设施致力于临床前成像研究，并提供广泛的示踪剂， 放射性配体，将可用于所提出的扫描仪。向CMGI提供的机构支助 确保其在使用寿命内的成功运行和维护。该工具将支持至少11个主要的 以及在神经病学、肿瘤学、 风湿病学、整形外科、纳米技术和生物医学工程。

PROJECT SUMMARY/ABSTRACT The goal of this proposal is to secure funding for an instrument dedicated to in vivo imaging of small animal models of human diseases via integrated positron emission tomography (PET)/X-ray computed tomography (CT). The instrument we propose is the GNEXT PET/CT system manufactured by Sofie Biosciences Inc. The PET component offers a high-resolution, high-sensitivity, and versatile platform for small-animal molecular imaging. The CT component is a fast, high-resolution system that enables sequential scanning for anatomy alongside molecular imaging by PET. This system will replace obsolete, stand-alone PET and CT scanners which are no longer supported by the manufacturer and for which certain key components are no longer available. The lack of support for these existing scanners is a major vulnerability for a wide range of preclinical imaging research at our institution. The PET/CT scanner will be installed at the UC Davis Center for Molecular and Genomic Imaging (CMGI), which is a campus-designated and supported core facility providing infrastructure and expertise to conduct in vivo imaging studies in small-animal models. CMGI oversees a cyclotron and radiochemistry facilities dedicated to preclinical imaging research and provides a wide range of tracers and radioligands that will be available to use with the proposed scanner. Institutional support provided to the CMGI ensures its successful operation and maintenance for its lifetime. The instrument will support at least 11 major and minor users who are conducting NIH-funded research in diverse areas such as neurology, oncology, rheumatology, orthopaedics, nanotechnology and biomedical engineering.