Multimodality PET/CT Scanner for Small Animal Imaging
用于小动物成像的多模态 PET/CT 扫描仪
基本信息
- 批准号:10429458
- 负责人:
- 金额:$ 87.82万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2022
- 资助国家:美国
- 起止时间:2022-04-15 至 2023-07-14
- 项目状态:已结题
- 来源:
- 关键词:AnatomyAnimal ModelAnimalsAreaBiological SciencesBiomedical EngineeringComputed Tomography ScannersCore FacilityCyclotronsEmission-Computed TomographyEnsureFundingGenomicsGoalsImageInfrastructureInstitutionMaintenanceManufacturer NameMinorMolecularNanotechnologyNeurologyOncologyOrthopedicsPositron-Emission TomographyRadiochemistryResearchResolutionRheumatologyScanningSecureSystemTracerUnited States National Institutes of HealthX-Ray Computed Tomographyanimal imaginghuman diseasehuman modelimaging studyin vivo imaginginstrumentmolecular imagingmultimodalityoperationpreclinical imagingradioligand
项目摘要
PROJECT SUMMARY/ABSTRACT
The goal of this proposal is to secure funding for an instrument dedicated to in vivo imaging of small animal
models of human diseases via integrated positron emission tomography (PET)/X-ray computed tomography
(CT). The instrument we propose is the GNEXT PET/CT system manufactured by Sofie Biosciences Inc. The
PET component offers a high-resolution, high-sensitivity, and versatile platform for small-animal molecular
imaging. The CT component is a fast, high-resolution system that enables sequential scanning for anatomy
alongside molecular imaging by PET. This system will replace obsolete, stand-alone PET and CT scanners
which are no longer supported by the manufacturer and for which certain key components are no longer
available. The lack of support for these existing scanners is a major vulnerability for a wide range of preclinical
imaging research at our institution. The PET/CT scanner will be installed at the UC Davis Center for Molecular
and Genomic Imaging (CMGI), which is a campus-designated and supported core facility providing infrastructure
and expertise to conduct in vivo imaging studies in small-animal models. CMGI oversees a cyclotron and
radiochemistry facilities dedicated to preclinical imaging research and provides a wide range of tracers and
radioligands that will be available to use with the proposed scanner. Institutional support provided to the CMGI
ensures its successful operation and maintenance for its lifetime. The instrument will support at least 11 major
and minor users who are conducting NIH-funded research in diverse areas such as neurology, oncology,
rheumatology, orthopaedics, nanotechnology and biomedical engineering.
项目摘要/摘要
这项提案的目标是为致力于小动物活体成像的仪器争取资金。
用正电子发射断层扫描(PET)/X射线计算机断层扫描建立人类疾病模型
(CT)。我们建议的仪器是苏菲生物科学公司制造的GNEXT PET/CT系统。
PET组件为小动物分子提供了一个高分辨率、高灵敏度和多功能的平台
成像。CT组件是一种快速、高分辨率的系统,可以对解剖进行顺序扫描
同时使用正电子发射计算机断层扫描进行分子成像。该系统将取代过时的、独立的PET和CT扫描仪
不再受制造商支持,并且某些关键组件不再受支持
可用。缺乏对这些现有扫描仪的支持是广泛的临床前疾病的主要弱点
我们机构的影像研究。PET/CT扫描仪将安装在加州大学戴维斯分子中心
和基因组成像(CMGI),这是一个园区指定和支持的核心设施,提供基础设施
以及在小动物模型上进行活体成像研究的专业知识。CMGI负责一个回旋加速器和
致力于临床前影像研究的放射化学设施,并提供广泛的示踪剂和
放射性配基将可用于拟议的扫描仪。向CMGI提供的机构支持
确保其在其生命周期内成功运行和维护。该工具将支持至少11个主要的
以及在神经学、肿瘤学等不同领域进行NIH资助的研究的小型用户,
风湿学、骨科、纳米技术和生物医学工程。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Abhijit J Chaudhari其他文献
Beyond skin deep: total-body positron emission tomography to illuminate systemic inflammation in psoriatic arthritis
不仅仅是表面现象:全身正电子发射断层扫描揭示银屑病关节炎中的全身性炎症
- DOI:
10.1016/j.coi.2025.102587 - 发表时间:
2025-08-01 - 期刊:
- 影响因子:5.800
- 作者:
Abhijit J Chaudhari;Yasser G Abdelhafez;Lorenzo Nardo;Siba P Raychaudhuri - 通讯作者:
Siba P Raychaudhuri
Abhijit J Chaudhari的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Abhijit J Chaudhari', 18)}}的其他基金
Total-body PET for assessing myofascial pain
用于评估肌筋膜疼痛的全身 PET
- 批准号:
10571508 - 财政年份:2022
- 资助金额:
$ 87.82万 - 项目类别:
Imaging biomarkers of early synaptic changes in a preclinical model of Alzheimer’s disease
阿尔茨海默病临床前模型中早期突触变化的成像生物标志物
- 批准号:
9980756 - 财政年份:2019
- 资助金额:
$ 87.82万 - 项目类别:
Total-Body PET/CT for assessing Rheumatoid Arthritis Disease Activity and Treatment Response
全身 PET/CT 用于评估类风湿性关节炎疾病活动性和治疗反应
- 批准号:
9817105 - 财政年份:2019
- 资助金额:
$ 87.82万 - 项目类别:
Quantifying synaptic density loss in a monkey model of early Alzheimer's Disease
量化早期阿尔茨海默病猴子模型中的突触密度损失
- 批准号:
9809280 - 财政年份:2019
- 资助金额:
$ 87.82万 - 项目类别:
Total-Body PET/CT for assessing Rheumatoid Arthritis Disease Activity and Treatment Response
全身 PET/CT 用于评估类风湿性关节炎疾病活动性和治疗反应
- 批准号:
10220852 - 财政年份:2019
- 资助金额:
$ 87.82万 - 项目类别:
Imaging biomarkers of early synaptic changes in a preclinical model of Alzheimer’s disease
阿尔茨海默病临床前模型中早期突触变化的成像生物标志物
- 批准号:
9807999 - 财政年份:2019
- 资助金额:
$ 87.82万 - 项目类别:
相似海外基金
Quantification of Neurovasculature Changes in a Post-Hemorrhagic Stroke Animal-Model
出血性中风后动物模型中神经血管变化的量化
- 批准号:
495434 - 财政年份:2023
- 资助金额:
$ 87.82万 - 项目类别:
Small animal model for evaluating the impacts of cleft lip repairing scar on craniofacial growth and development
评价唇裂修复疤痕对颅面生长发育影响的小动物模型
- 批准号:
10642519 - 财政年份:2023
- 资助金额:
$ 87.82万 - 项目类别:
Bioactive Injectable Cell Scaffold for Meniscus Injury Repair in a Large Animal Model
用于大型动物模型半月板损伤修复的生物活性可注射细胞支架
- 批准号:
10586596 - 财政年份:2023
- 资助金额:
$ 87.82万 - 项目类别:
A Comparison of Treatment Strategies for Recovery of Swallow and Swallow-Respiratory Coupling Following a Prolonged Liquid Diet in a Young Animal Model
幼年动物模型中长期流质饮食后吞咽恢复和吞咽呼吸耦合治疗策略的比较
- 批准号:
10590479 - 财政年份:2023
- 资助金额:
$ 87.82万 - 项目类别:
Diurnal grass rats as a novel animal model of seasonal affective disorder
昼夜草鼠作为季节性情感障碍的新型动物模型
- 批准号:
23K06011 - 财政年份:2023
- 资助金额:
$ 87.82万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Longitudinal Ocular Changes in Naturally Occurring Glaucoma Animal Model
自然发生的青光眼动物模型的纵向眼部变化
- 批准号:
10682117 - 财政年份:2023
- 资助金额:
$ 87.82万 - 项目类别:
A whole animal model for investigation of ingested nanoplastic mixtures and effects on genomic integrity and health
用于研究摄入的纳米塑料混合物及其对基因组完整性和健康影响的整体动物模型
- 批准号:
10708517 - 财政年份:2023
- 资助金额:
$ 87.82万 - 项目类别:
A Novel Large Animal Model for Studying the Developmental Potential and Function of LGR5 Stem Cells in Vivo and in Vitro
用于研究 LGR5 干细胞体内外发育潜力和功能的新型大型动物模型
- 批准号:
10575566 - 财政年份:2023
- 资助金额:
$ 87.82万 - 项目类别:
Elucidating the pathogenesis of a novel animal model mimicking chronic entrapment neuropathy
阐明模拟慢性卡压性神经病的新型动物模型的发病机制
- 批准号:
23K15696 - 财政年份:2023
- 资助金额:
$ 87.82万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
The effect of anti-oxidant on swallowing function in an animal model of dysphagia
抗氧化剂对吞咽困难动物模型吞咽功能的影响
- 批准号:
23K15867 - 财政年份:2023
- 资助金额:
$ 87.82万 - 项目类别:
Grant-in-Aid for Early-Career Scientists