Multimodality PET/CT Scanner for Small Animal Imaging

用于小动物成像的多模态 PET/CT 扫描仪

• 批准号: 10429458
• 负责人: Abhijit J Chaudhari
• 金额: $ 87.82万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-04-15 至 2023-07-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10429458
• 关键词: Anatomy; Animal Model; Animals; Area; Biological Sciences; Biomedical Engineering; Computed Tomography Scanners; Core Facility; Cyclotrons; Emission-Computed Tomography; Ensure; Funding; Genomics; Goals; Image; Infrastructure; Institution; Maintenance; Manufacturer Name; Minor; Molecular; Nanotechnology; Neurology; Oncology; Orthopedics; Positron-Emission Tomography; Radiochemistry; Research; Resolution; Rheumatology; Scanning; Secure; System; Tracer; United States National Institutes of Health; X-Ray Computed Tomography; animal imaging; human disease; human model; imaging study; in vivo imaging; instrument; molecular imaging; multimodality; operation; preclinical imaging; radioligand

PROJECT SUMMARY/ABSTRACT The goal of this proposal is to secure funding for an instrument dedicated to in vivo imaging of small animal models of human diseases via integrated positron emission tomography (PET)/X-ray computed tomography (CT). The instrument we propose is the GNEXT PET/CT system manufactured by Sofie Biosciences Inc. The PET component offers a high-resolution, high-sensitivity, and versatile platform for small-animal molecular imaging. The CT component is a fast, high-resolution system that enables sequential scanning for anatomy alongside molecular imaging by PET. This system will replace obsolete, stand-alone PET and CT scanners which are no longer supported by the manufacturer and for which certain key components are no longer available. The lack of support for these existing scanners is a major vulnerability for a wide range of preclinical imaging research at our institution. The PET/CT scanner will be installed at the UC Davis Center for Molecular and Genomic Imaging (CMGI), which is a campus-designated and supported core facility providing infrastructure and expertise to conduct in vivo imaging studies in small-animal models. CMGI oversees a cyclotron and radiochemistry facilities dedicated to preclinical imaging research and provides a wide range of tracers and radioligands that will be available to use with the proposed scanner. Institutional support provided to the CMGI ensures its successful operation and maintenance for its lifetime. The instrument will support at least 11 major and minor users who are conducting NIH-funded research in diverse areas such as neurology, oncology, rheumatology, orthopaedics, nanotechnology and biomedical engineering.

项目概要/摘要 该提案的目标是为专门用于小动物体内成像的仪器争取资金 通过集成正电子发射断层扫描 (PET)/X 射线计算机断层扫描建立人类疾病模型 （CT）。我们建议的仪器是 Sofie Biosciences Inc. 制造的 GNEXT PET/CT 系统。 PET 组件为小动物分子提供高分辨率、高灵敏度和多功能平台 成像。 CT 组件是一种快速、高分辨率的系统，可实现解剖结构的顺序扫描 与 PET 分子成像一起。该系统将取代过时的独立 PET 和 CT 扫描仪 制造商不再支持，并且某些关键组件不再 可用的。缺乏对这些现有扫描仪的支持是各种临床前扫描仪的一个主要漏洞 我们机构的影像研究。 PET/CT 扫描仪将安装在加州大学戴维斯分校分子中心 基因组成像（CMGI），这是校园指定和支持的核心设施，提供基础设施 以及在小动物模型中进行体内成像研究的专业知识。 CMGI 负责监督回旋加速器和 放射化学设施致力于临床前成像研究，并提供广泛的示踪剂和 可与建议的扫描仪一起使用的放射性配体。向 CMGI 提供的机构支持 确保其在整个生命周期内成功运行和维护。该仪器将支持至少 11 个主要 以及在神经学、肿瘤学等不同领域进行 NIH 资助研究的未成年用户 风湿病学、骨科、纳米技术和生物医学工程。