Multimodality PET/CT Scanner for Small Animal Imaging

项目摘要/摘要 这项提案的目标是为致力于小动物活体成像的仪器争取资金。 用正电子发射断层扫描(PET)/X射线计算机断层扫描建立人类疾病模型 (CT)。我们建议的仪器是苏菲生物科学公司制造的GNEXT PET/CT系统。 PET组件为小动物分子提供了一个高分辨率、高灵敏度和多功能的平台 成像。CT组件是一种快速、高分辨率的系统，可以对解剖进行顺序扫描 同时使用正电子发射计算机断层扫描进行分子成像。该系统将取代过时的、独立的PET和CT扫描仪 不再受制造商支持，并且某些关键组件不再受支持 可用。缺乏对这些现有扫描仪的支持是广泛的临床前疾病的主要弱点 我们机构的影像研究。PET/CT扫描仪将安装在加州大学戴维斯分子中心 和基因组成像(CMGI)，这是一个园区指定和支持的核心设施，提供基础设施 以及在小动物模型上进行活体成像研究的专业知识。CMGI负责一个回旋加速器和 致力于临床前影像研究的放射化学设施，并提供广泛的示踪剂和 放射性配基将可用于拟议的扫描仪。向CMGI提供的机构支持 确保其在其生命周期内成功运行和维护。该工具将支持至少11个主要的 以及在神经学、肿瘤学等不同领域进行NIH资助的研究的小型用户， 风湿学、骨科、纳米技术和生物医学工程。

PROJECT SUMMARY/ABSTRACT The goal of this proposal is to secure funding for an instrument dedicated to in vivo imaging of small animal models of human diseases via integrated positron emission tomography (PET)/X-ray computed tomography (CT). The instrument we propose is the GNEXT PET/CT system manufactured by Sofie Biosciences Inc. The PET component offers a high-resolution, high-sensitivity, and versatile platform for small-animal molecular imaging. The CT component is a fast, high-resolution system that enables sequential scanning for anatomy alongside molecular imaging by PET. This system will replace obsolete, stand-alone PET and CT scanners which are no longer supported by the manufacturer and for which certain key components are no longer available. The lack of support for these existing scanners is a major vulnerability for a wide range of preclinical imaging research at our institution. The PET/CT scanner will be installed at the UC Davis Center for Molecular and Genomic Imaging (CMGI), which is a campus-designated and supported core facility providing infrastructure and expertise to conduct in vivo imaging studies in small-animal models. CMGI oversees a cyclotron and radiochemistry facilities dedicated to preclinical imaging research and provides a wide range of tracers and radioligands that will be available to use with the proposed scanner. Institutional support provided to the CMGI ensures its successful operation and maintenance for its lifetime. The instrument will support at least 11 major and minor users who are conducting NIH-funded research in diverse areas such as neurology, oncology, rheumatology, orthopaedics, nanotechnology and biomedical engineering.