Total-body PET for assessing myofascial pain

用于评估肌筋膜疼痛的全身 PET

• 批准号: 10571508
• 负责人: Abhijit J Chaudhari
• 金额: $ 209.74万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-19 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10571508
• 关键词: Acupuncture Therapy; Address; Adult; Affect; American; Anatomy; Area; Back; Beds; Biological Markers; Butanols; Cell physiology; Chronic low back pain; Clinical; Collaborations; Complex; Cross-Sectional Studies; Data; Diagnosis; Disease; Dose; Emission-Computed Tomography; Evaluation; Facilities and Administrative Costs; Functional disorder; Goals; Grant; Health Care Costs; Health Policy; Hemoglobinopathies; Human body; Image; Imaging Device; Infiltration; Inflammation; Infrastructure; Institutes; Intervention; Intervention Studies; Label; Malignant Neoplasms; Measures; Metabolism; Methods; Monitor; Musculoskeletal Pain; Myofascial Pain Syndromes; Observational Study; Outcome Measure; Pain; Participant; Pathogenesis; Pathology; Patient Recruitments; Perfusion; Phase; Positioning Attribute; Positron-Emission Tomography; Process; Quantitative Evaluations; Randomized; Regional Perfusion; Resolution; Resources; Scanning; Sickle Cell Anemia; Societies; Source; Study Section; Syndrome; System; Testing; Time; Tissues; Trauma; United States National Institutes of Health; Visualization; Work; X-Ray Computed Tomography; arm; base; demographics; experience; fluorodeoxyglucose; follow-up; glucose metabolism; imaging biomarker; imaging modality; in vivo; industry partner; insight; interest; molecular imaging; novel; outcome prediction; potential biomarker; radiotracer; response; therapy outcome; tool; treatment arm

Project Summary Myofascial pain syndrome (MPS) is a prevalent and debilitating condition representing a significant burden to society. This syndrome may occur as an isolated condition, often localized in the lower back area, or be part of more complex clinical scenarios, such as hemoglobinopathy, inflammation, cancer and trauma, that affect the myofascial unit. There is a paucity of validated biomarkers for qualitative or quantitative assessment of MPS. The objective of this proposal is to establish novel measures derived from Total-body-Positron Emission Tomography/Computed Tomography (TB-PET/CT) as quantitative biomarkers to monitor response and predict outcomes for interventions that have potential to relieve myofascial pain. The TB-PET/CT measures we will assess include those reflective of myofascial tissue metabolism, perfusion, and fatty infiltration. These processes are intimately associated with myofascial tissue dysfunction and monitoring them may provide means to assess sources of pain. Therefore, this proposal is responsive to the RFA-AT-22-003 and addresses the interest area: “Quantitative evaluation of tissue metabolism, perfusion, oxygenation, and fatty infiltration”. The condition assessed in this proposal is chronic low back pain. We hypothesize that TB-PET/CT measures will (1) offer a unique insight into myofascial tissue pathology in this condition; and (2) provide biomarkers that will associate with myofascial tissue dysfunction and response to interventions. The proposed project will have two phases. The first is the R61 phase where we will conduct an observational, cross-sectional study. In this phase we will establish the association of quantitative TB-PET/CT measures with HEAL outcome measures and will determine TB-PET/CT measures that differentiate diseased versus healthy myofascial tissue. The second phase will be the R33 phase where we will carry out a randomized, controlled longitudinal interventional study. Participants will be randomly assigned to the intervention arm or the control arm. In this phase we will determine the capability of TB-PET/CT measures to track with changes in HEAL outcome measures in response to the intervention. We have defined quantitative transition criteria that will be applied to the imaging measures in the R61 phase before introducing them into the R33 phase. Therefore, through this work we hope to establish TB-PET/CT measures as potential biomarkers for providing the much-needed objectivity, sensitivity, and precision for characterizing myofascial tissue, and as surrogate measures for dysfunction, pain and for predicting and monitoring response to interventions.

项目摘要 肌筋膜疼痛综合征(MPS)是一种流行的、使人衰弱的疾病，给社会带来了巨大的负担。这种综合征可能以孤立的状态出现，通常局限于下背部，也可能是更复杂的临床情况的一部分，例如影响肌筋膜单位的血红蛋白病、炎症、癌症和创伤。目前缺乏用于MPS定性或定量评估的有效生物标志物。这项建议的目的是建立源自全身正电子发射断层扫描/计算机断层扫描(TB-PET/CT)的新指标，作为监测反应和预测有可能缓解肌筋膜疼痛的干预措施的定量生物标记物。我们将评估的TB-PET/CT措施包括那些反映肌筋膜组织代谢、灌注和脂肪渗透的措施。这些过程与肌筋膜组织功能障碍密切相关，监测它们可能提供评估疼痛来源的手段。因此，该提案响应了RFA-AT-22-003，并解决了感兴趣的领域：“定量评估组织新陈代谢、血流、氧合和脂肪渗透”。在这项建议中评估的情况是慢性下腰痛。我们假设，TB-PET/CT测量将(1)提供对这种情况下肌筋膜组织病理的独特洞察；(2)提供与肌筋膜组织功能障碍和干预反应相关的生物标志物。 拟议的项目将分为两个阶段。第一个阶段是R61阶段，我们将在这个阶段进行观察性的横断面研究。在这一阶段，我们将建立定量TB-PET/CT测量与愈合结果测量的关联，并将确定区分病变和健康肌筋膜组织的TB-PET/CT测量。第二阶段将是R33阶段，我们将在该阶段开展一项随机、对照的纵向干预研究。参与者将被随机分配到干预组或控制组。在这一阶段，我们将确定TB-PET/CT测量的能力，以跟踪干预后愈合结果测量的变化。我们已经定义了定量转换标准，在将其引入R33阶段之前，将应用于R61阶段中的成像措施。因此，通过这项工作，我们希望建立TB-PET/CT指标作为潜在的生物标志物，提供急需的客观性、敏感性和精确度来表征肌筋膜组织，并作为功能障碍、疼痛以及预测和监测干预反应的替代指标。