Core B: Neuroimaging Core

核心 B：神经影像核心

• 批准号: 10684077
• 负责人: Abhijit J Chaudhari
• 金额: $ 27.2万
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2027-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10684077
• 关键词: Acute; Affect; Brain; Brain imaging; Budgets; Chronic; Collaborations; Communities; Data; Data Analyses; Dedications; Derivation procedure; Development; Dimensions; Disease; Doctor of Philosophy; Emerging Technologies; Ensure; Equipment; Fluorescence; Functional Imaging; Functional disorder; Future; Genomics; Goals; Grant; Human; IACUC; Image; Image Analysis; Imaging Device; Imaging technology; Intoxication; Lead; Machine Learning; Magnetic Resonance Imaging; Manuscripts; Measures; Medical Imaging; Methods; Microscopic; Military Personnel; Mission; Modality; Modernization; Molecular; Monitor; Neurologic; Organophosphates; Pharmacology; Positron-Emission Tomography; Preparation; Protocols documentation; Radiology Specialty; Reproducibility; Research; Research Personnel; Resources; Scientist; Surrogate Endpoint; Technology; Therapeutic; Therapeutic Intervention; Tissue imaging; Tracer; Training; Translating; Validation; X-Ray Computed Tomography; analysis pipeline; anatomic imaging; animal imaging; cellular imaging; data acquisition; design; education research; experience; experimental study; fluorescence imaging; human imaging; image processing; imaging Segmentation; imaging biomarker; imaging modality; imaging probe; imaging science; imaging study; improved; in vivo; in vivo imaging; kinetic model; molecular imaging; multimodality; neuroimaging; neuroimaging marker; neuropathology; neurotoxicology; novel; optical imaging; professor; quantitative imaging; radiotracer; response; structural imaging; success; targeted imaging; therapeutically effective; tool; toxic organophosphate insecticide exposure; virtual

Project Summary – Neuroimaging Core – Core B The Neuroimaging Core will provide UC Davis CounterACT Center investigators with outstanding resources in the rapidly evolving field of neuroimaging technologies, for which there is strong demand by all three scientific Projects. Neuroimaging tools provide one of the best modern means for examining the pathophysiology of disorders that affect the brain. Center investigators have previously shown the benefits of neuroimaging technologies for evaluating the short- and long-term consequences of acute organophosphate intoxication on the brain and identifying effective therapeutic strategies that mitigate the resulting neuropathology. The Neuroimaging Core will capitalize on these previous successes and provide state-of-the-art equipment for neuroimaging spanning microscopic to whole brain in vivo imaging, and dedicated expertise in image acquisition, analysis and the development and validation of imaging biomarkers to support the scientific Projects. The neuroimaging resources provided will include modalities focused on structural neuroimaging, such as magnetic resonance imaging (MRI) and X-ray computed tomography (CT), functional and molecular imaging, such as MRI and positron emission tomography (PET), and correlative cellular high-content brightfield and fluorescence tissue imaging. Oversight and management of the Neuroimaging Core will be provided by Core Lead, Abhijit Chaudhari, PhD, Professor of Radiology and the Director of the UC Davis Center for Molecular and Genomic Imaging (CMGI), with over 15 years of experience in animal and human imaging with various imaging modalities, quantitative imaging science, imaging biomarker design and validation and medical image processing; and Core Co-Lead, Brad Hobson, PhD, Research Scientist at the CMGI, who has extensive training in neurotoxicology, pharmacology and the validation of ex vivo and in vivo neuroimaging methods in the context of organophosphate exposure. The objectives of the Neuroimaging Core are to: (1) provide Center investigators with access to a wide array of neuroimaging technologies ranging from cellular imaging to macroscopic in vivo structural, functional, and molecular imaging in pursuit of the scientific aims of the Projects; (2) develop and deploy advanced imaging technologies that will enhance Center investigators’ research endeavors.; and (3) contribute to the research education mission of the Center by providing virtual and hands-on training in the utilization of imaging methods, data acquisition, and image analysis. By providing neuroimaging expertise, the Core will ensure that imaging studies by the UC Davis Center investigators are designed, implemented, and analyzed rigorously to ensure transparency, reproducibility and future translatability to humans.

项目总结-神经成像核心-核心B 神经影像学核心将为加州大学戴维斯分校CounterACT中心的研究人员提供出色的资源， 快速发展的神经成像技术领域，这三个科学领域都有强烈的需求。 项目神经影像学工具提供了一个最好的现代手段，检查的病理生理， 影响大脑的疾病中心的研究人员以前已经证明了神经成像的好处 急性有机磷中毒对儿童的短期和长期影响的评估技术 大脑和确定有效的治疗策略，减轻由此产生的神经病理学。的 神经影像核心将利用这些以前的成功，并提供最先进的设备， 神经成像，从显微镜到全脑活体成像，以及图像采集方面的专业知识， 分析以及开发和验证成像生物标志物，以支持科学项目。的 提供的神经成像资源将包括侧重于结构神经成像的模式，如磁共振成像， 磁共振成像（MRI）和X射线计算机断层扫描（CT），功能和分子成像，如MRI 和正电子发射断层扫描（PET），以及相关的细胞高含量明场和荧光组织 显像神经影像学核心的监督和管理将由核心负责人Abhijit Chaudhari提供， 加州大学戴维斯分校分子和基因组成像中心主任 （CMGI），在各种成像模式的动物和人类成像方面拥有超过15年的经验， 定量成像科学、成像生物标志物设计和验证以及医学图像处理;以及核心 共同负责人，布拉德霍布森博士，CMGI研究科学家，他在神经毒理学方面接受过广泛的培训， 药理学以及在有机磷背景下离体和体内神经成像方法的验证 exposure.神经影像学核心的目标是：（1）为中心研究者提供访问 广泛的神经成像技术，从细胞成像到宏观体内结构， （2）开发和部署用于实现项目科学目标的功能成像和分子成像技术; 先进的成像技术，这将增强中心研究人员的研究努力。（3）贡献 该中心的研究教育使命，提供虚拟和实践培训，利用 成像方法、数据采集和图像分析。通过提供神经影像学专业知识，核心将 确保加州大学戴维斯分校中心研究人员的成像研究得到设计、实施和分析 严格确保透明度、可重复性和未来可翻译性。