In Vivo Translational Imaging Shared Resource

体内转化成像共享资源

• 批准号: 10492615
• 负责人: Abhijit J Chaudhari
• 金额: --
• 依托单位: UNIVERSITY OF CALIFORNIA AT DAVIS
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-07-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10492615
• 关键词: Address; Animal Cancer Model; Animal Model; Animals; Budgets; Cancer Center Support Grant; Cancer Grant Supplements (P30); Cancer Model; Canis familiaris; Clinic; Comprehensive Cancer Center; Data Analyses; Diagnosis; Diagnostic; Doctor of Philosophy; Emission-Computed Tomography; Equipment; Experimental Designs; Felis catus; Foundations; Functional Imaging; Genomics; Grant; Human; IACUC; Image; Imaging technology; Individual; Institutional Review Boards; Magnetic Resonance Imaging; Malignant Neoplasms; Manuscripts; Medical Imaging; Molecular; Outcome; Positron-Emission Tomography; Preparation; Process; Protocols documentation; Radiochemistry; Research; Resource Sharing; Resources; Rodent Model; Technology; Therapeutic; Tracer; Training; Translations; Ultrasonography; X-Ray Computed Tomography; anatomic imaging; cancer imaging; cancer therapy; companion animal; design verification; experience; follow-up; human disease; human model; image processing; imaging biomarker; imaging facilities; imaging modality; imaging probe; imaging science; imaging study; in vivo; in vivo imaging; member; molecular imaging; non-invasive imaging; optical imaging; pre-clinical; quantitative imaging; radiologist; single photon emission computed tomography; targeted imaging; tool; ultrasound

IN VIVO TRANSLATIONAL IMAGING SHARED RESOURCE (IVTISR) PROJECT SUMMARY/ABSTRACT The In Vivo Translational Imaging Shared Resource (IVTISR) was developed to provide UC Davis Comprehensive Cancer Center (UCDCCC) members outstanding resources in the rapidly evolving field of non- invasive imaging technologies, addressing the strong demand for these technologies by UCDCCC members. In vivo imaging in animal models of human disease and in humans is an integral part of addressing cancer outcomes and in assessing and addressing diagnostic and therapeutic approaches. The IVTISR provides in vivo imaging equipment, and dedicated imaging protocols and expertise that are critical to the advancement of understanding basic mechanisms of cancer as well as the translation of new oncologic diagnostic and therapeutic tools to the clinic. Guidance is also provided on experimental design involving in vivo imaging, Institutional Animal Care and Use Committee (IACUC) and Institutional Review Board (IRB) protocols, imaging data analysis and interpretation, as well as on manuscript and grant preparation/budgeting. The IVTISR consists of three units; the Center for Molecular and Genomic Imaging (CMGI) that supports small animal in vivo imaging, biospecimen imaging and preclinical radiochemistry, the Center for Imaging Science (CIS) that supports imaging studies in large animals, and the EXPLORER Molecular Imaging Center (EMIC), that supports human positron emission tomography/computed tomography (PET/CT) studies. Therefore, as a whole this shared resource uniquely supports imaging studies from rodent models of cancer to larger animals such as cats and dogs with spontaneous cancers to humans with oncologic conditions. Oversight and management of the IVTISR is provided by the Director, Abhijit Chaudhari, MS, PhD, the Director of the CMGI with over 15 years of experience in animal and human cancer imaging with various imaging modalities, quantitative imaging science, imaging biomarker design and validation and medical image processing; the co- Director, Allison Zwingenberger, DVM, MAS, a board-certified veterinary radiologist with extensive experience in cancer imaging using CT, MRI, and ultrasound in companion animal models of cancer; and the co-Director, Lorenzo Nardo, MD, PhD, radiologist with extensive training in MRI, CT, and molecular imaging in the diagnosis, follow up and treatment of cancer. The Specific Aims for the IVTISR are to: 1) Provide UCDCCC members with access to a broad range of in vivo imaging technologies, including molecular imaging technologies, such as PET, single photon emission computed tomography (SPECT) and optical imaging, quantitative physiologic imaging with ultrasound, and anatomic imaging with CT and magnetic resonance imaging (MRI). 2) Provide expertise in planning, executing and analyzing in vivo imaging studies. 3) Support imaging studies in rodent models (primarily at the CMGI), in larger animals with spontaneously arising cancers (primarily at the CIS), and humans (primarily at the EMIC). 4) Continue to seek state-of-the-art in vivo imaging technologies that will enhance UCDCCC members' research endeavors.

体内平移成像共享资源（ivtisr）