Biostatistics/Bioinformatics Core

项目总结 本P01的生物统计和生物信息学核心(D核心)将提供统计和生物信息学 对所有研究项目和核心进行协作和咨询。这项研究提供了咨询服务 通过实施、数据管理、统计和生物信息学分析的设计和规划阶段， 以及对结果的解释。核心D将为所有拟议的实验室研究和翻译提供支持 研究，包括基于人体样本的各种生物标记物的调查和动物研究，以支持 P01的总体任务和中心科学战略。此外，系统化的战略 从所有项目中挑选样本，协调#年的信息学支助和数据管理 核心D将允许跨P01项目的数据共享和结果整体集成，以开发新的 认识阿尔茨海默病的发病机制和治疗方法。

PROJECT SUMMARY The Biostatistics and Bioinformatics Core (Core D) of this P01 will provide statistical and bioinformatics collaboration and consultation to all Research Projects and Cores. Consultation is available from the study design and planning stages through implementation, data management, statistical and bioinformatics analysis, and interpretation of results. Core D will provide support for all proposed laboratory studies and translational studies, including investigation of various biomarkers based on human samples and animal studies to support the overarching mission and central scientific strategy of the P01. Furthermore, strategies for the systematic selection of samples from all the projects and the coordination of informatics support and data management in Core D will permit data sharing and overall integration of results across projects of this P01 to develop novel approaches to understanding the pathogenesis and treating AD.