Biostatistics/Bioinformatics Core

项目摘要 本P01的生物统计学和生物信息学核心（核心D）将提供统计学和生物信息学 所有研究项目和核心的合作和咨询。可从研究中获得咨询 设计和规划阶段，包括实施、数据管理、统计和生物信息分析， 和结果的解释。核心D将为所有拟议的实验室研究和翻译提供支持。 研究，包括基于人类样本和动物研究的各种生物标志物的研究，以支持 P01的首要使命和中心科学战略。此外，系统性的 从所有项目中选择样本，并协调信息支持和数据管理， 核心D将允许本P01项目之间的数据共享和结果的整体整合，以开发新的 了解AD的发病机制和治疗方法。

PROJECT SUMMARY The Biostatistics and Bioinformatics Core (Core D) of this P01 will provide statistical and bioinformatics collaboration and consultation to all Research Projects and Cores. Consultation is available from the study design and planning stages through implementation, data management, statistical and bioinformatics analysis, and interpretation of results. Core D will provide support for all proposed laboratory studies and translational studies, including investigation of various biomarkers based on human samples and animal studies to support the overarching mission and central scientific strategy of the P01. Furthermore, strategies for the systematic selection of samples from all the projects and the coordination of informatics support and data management in Core D will permit data sharing and overall integration of results across projects of this P01 to develop novel approaches to understanding the pathogenesis and treating AD.