Maintain and Enrich Resource Infrastructure for Project Viva: a pre-birth cohort with follow up into adolescence

项目摘要/摘要 此应用程序响应RFA-ES-18-009：维护和丰富资源基础架构 现有环境流行病学队列 Viva项目是波士顿地区的一个队列，由2128对母婴组成，我们从他们那里收集了关于 1999-2002年从怀孕早期开始的大量环境暴露和健康后果。我们的 因此，近20年的数据跨越了生命过程的无数敏感期：尽管是从怀孕开始 指数参与者的青春期，以及他们的母亲从怀孕进入围绝经期。我们的 丰富的数据库包含大量环境暴露的详细信息，包括日常空气 来自卫星、本地监视器和地理信息系统的污染暴露估计.测量 建筑和自然环境.包括全氟烷基物质和多氟烷基物质(PFAS)在内的毒物的生物标志物 和金属；以及母婴饮食。现有的研究质量成果包括衡量 母亲和儿童的心脏代谢健康(人体测量、身体成分、血压和 血糖、血脂和脂肪因子的生物标志物)；儿童认知和行为；儿童肺功能和特应性；AS 以及遗传变异和表观遗传标记。 当前提案的总体目标是：1)通过以下方式支持留住Viva项目指数参与者 青春期进入青壮年过渡期，2)通过发展和发展为未来的科学建立基础设施 利用现代技术实施远程数据收集方法，重点是环境 以及3)加强我们的数据管理基础设施，以促进与更广泛的 科学界。这些活动将补充我们现有的现有赠款，支持数据收集和 分析，包括参与NIH的环境对儿童健康结局的影响(ECHO) 程序。 Project Viva中已有的丰富数据和生物样本为继续提供了独特的机会 推进NIEHS的研究重点，包括研究早期生命环境的影响 单独暴露以及与其他暴露和遗传因素相结合，对慢性疾病的发展有重要影响。 拟议的基础设施活动将改善向更广泛的研究提供Viva项目数据 社区，同时支持我们努力保持这一宝贵的资源和我们的立场 在未来研究新的科学问题。改进后的基础设施还将提供 可扩展的基础，以支持Project Viva协议和数据集的持续丰富。

Project Summary/Abstract This application is responsive to RFA-ES-18-009: Maintain and Enrich Resource Infrastructure for Existing Environmental Epidemiology Cohorts Project Viva is a Boston-area cohort of 2,128 mother-child pairs from whom we have collected information on numerous environmental exposures and health outcomes beginning in early pregnancy in 1999-2002. Our almost two decades of data thus traverse numerous sensitive periods of the lifecourse: from gestation though adolescence for index participants, and from pregnancy into the perimenopausal period for their mothers. Our rich database comprises detailed information on a wealth of environmental exposures including daily air pollution exposure estimates from satellites, local monitors, and geographic information systems; measures of built and natural environments; biomarkers of toxicants including per- and polyfluoroalkyl substances (PFAS) and metals; and maternal and child diet. Existing research-quality outcomes include measures of cardiometabolic health for both mothers and children (anthropometry, body composition, blood pressure, and biomarkers of glycemia, lipids, and adipokines); child cognition and behavior; child lung function and atopy; as well as genetic variants and epigenetic markers. The overall goals of the current proposal are to 1) bolster retention of Project Viva index participants through adolescence into the young adult transition, 2) build infrastructure for future science through development and implementation of remote data collection methods using modern technology, with a focus on environmental exposures, and 3) enhance our data management infrastructure to facilitate data sharing with the broader scientific community. These activities will complement our existing active grants supporting data collection and analysis, including participation in the NIH’s Environmental Influences on Child Health Outcomes (ECHO) Program. The wealth of data and biosamples already available in Project Viva provide a unique opportunity to continue to advance the research priorities of NIEHS, including examining the influence of early-life environmental exposures, alone and in combination with other exposures and genetics, on development of chronic disease. The proposed infrastructure activities will improve the availability of Project Viva data to the wider research community, while simultaneously supporting our efforts to maintain this valuable resource and position our cohort to examine novel scientific questions in the future. The enhanced infrastructure will also provide a scalable foundation to support ongoing enrichment of the Project Viva protocols and datasets.