Maintain and Enrich Resource Infrastructure for Project Viva: a pre-birth cohort with follow up into adolescence

维护和丰富 Viva 项目的资源基础设施：出生前队列，并跟踪青春期

• 批准号: 10429909
• 负责人: Emily Oken
• 金额: $ 39.86万
• 依托单位: HARVARD PILGRIM HEALTH CARE, INC.
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-04-01 至 2025-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10429909
• 关键词: Accelerometer; Address; Adolescence; Air Pollution; Anthropometry; Area; Asthma; Behavior; Biological; Biological Markers; Birth; Blood Pressure; Body Composition; Boston; Cardiovascular Diseases; Cellular Phone; Child; Child Health; Chronic Disease; Cognition; Communication Methods; Communities; Complement; DNA analysis; Data; Data Analyses; Data Collection; Data Set; Databases; Development; Diet; Dietary Assessment; Documentation; Ecological momentary assessment; Electronic Mail; Enrollment; Environment; Environmental Epidemiology; Environmental Exposure; Environmental Health; Fathers; Feedback; Focus Groups; Foundations; Future; Genetic; Geographic Information Systems; Geography; Goals; Grant; Health; Infrastructure; Infrastructure Activities; Internet; Life; Link; Lipids; Location; Longitudinal cohort study; Measures; Metals; Methods; Modernization; Monitor; Moods; Mothers; National Institute of Environmental Health Sciences; Obesity; Online Systems; Outcome; Participant; Pattern; Perimenopause; Physical activity; Poly-fluoroalkyl substances; Positioning Attribute; Pregnancy; Protocols documentation; Records; Research; Research Priority; Resolution; Resources; Sampling; Science; Secure; Techniques; Technology; Testing; Time; United States National Institutes of Health; adipokines; atopy; base; cardiometabolism; cohort; data management; data sharing; data warehouse; design; early pregnancy; epigenetic marker; follow-up; genetic variant; improved; indexing; member; novel; patient engagement; programs; pulmonary function; saliva sample; search engine; sleep pattern; smartphone Application; substance use; toxicant; web portal; young adult

Project Summary/Abstract This application is responsive to RFA-ES-18-009: Maintain and Enrich Resource Infrastructure for Existing Environmental Epidemiology Cohorts Project Viva is a Boston-area cohort of 2,128 mother-child pairs from whom we have collected information on numerous environmental exposures and health outcomes beginning in early pregnancy in 1999-2002. Our almost two decades of data thus traverse numerous sensitive periods of the lifecourse: from gestation though adolescence for index participants, and from pregnancy into the perimenopausal period for their mothers. Our rich database comprises detailed information on a wealth of environmental exposures including daily air pollution exposure estimates from satellites, local monitors, and geographic information systems; measures of built and natural environments; biomarkers of toxicants including per- and polyfluoroalkyl substances (PFAS) and metals; and maternal and child diet. Existing research-quality outcomes include measures of cardiometabolic health for both mothers and children (anthropometry, body composition, blood pressure, and biomarkers of glycemia, lipids, and adipokines); child cognition and behavior; child lung function and atopy; as well as genetic variants and epigenetic markers. The overall goals of the current proposal are to 1) bolster retention of Project Viva index participants through adolescence into the young adult transition, 2) build infrastructure for future science through development and implementation of remote data collection methods using modern technology, with a focus on environmental exposures, and 3) enhance our data management infrastructure to facilitate data sharing with the broader scientific community. These activities will complement our existing active grants supporting data collection and analysis, including participation in the NIH’s Environmental Influences on Child Health Outcomes (ECHO) Program. The wealth of data and biosamples already available in Project Viva provide a unique opportunity to continue to advance the research priorities of NIEHS, including examining the influence of early-life environmental exposures, alone and in combination with other exposures and genetics, on development of chronic disease. The proposed infrastructure activities will improve the availability of Project Viva data to the wider research community, while simultaneously supporting our efforts to maintain this valuable resource and position our cohort to examine novel scientific questions in the future. The enhanced infrastructure will also provide a scalable foundation to support ongoing enrichment of the Project Viva protocols and datasets.

项目摘要/摘要 此应用程序对RFA-ES-18-009响应：维护和丰富资源基础架构 现有的环境流行病学队列 Viva Project是波士顿地区的2,128对母子对的队列 从1999 - 2002年怀孕初期开始，许多环境暴露和健康结果。我们的 因此，将近二十年的数据遍历了生命的许多敏感时期：虽然妊娠 指数参与者的青少年，从怀孕到母亲的围绝经期。我们的 丰富的数据库包含有关大量环境暴露在内的详细信息，包括日常空气 卫星，当地监视器和地理信息系统的污染暴露估计；措施 建造和自然环境；毒物的生物标志物在内 和金属；以及Matal和儿童饮食。现有的研究质量结果包括测量 母亲和儿童的心脏代谢健康（人体测量法，身体成分，血压和 血糖，脂质和脂肪因子的生物标志物）；儿童认知和行为；儿童肺功能和特纳；作为 以及遗传变异和表观遗传标记。 当前建议的总体目标是1）通过 青少年进入年轻成人过渡，2）通过发展和 使用现代技术实施远程数据收集方法，重点是环境 3）增强我们的数据管理基础架构，以促进数据共享 科学界。这些活动将完成我们现有的主动赠款，支持数据收集，并 分析，包括参与NIH对儿童健康成果的影响（ECHO） 程序。 Viva项目中已经可用的大量数据和生物样本提供了一个独特的机会来继续 提高NIEH的研究优先事项，包括研究早期环境的影响 单独的暴露与其他暴露和遗传学结合了慢性疾病的发展。 拟议的基础设施活动将改善项目Viva数据的可用性 社区，同时支持我们维持这一宝贵资源并定位我们的努力 在将来研究新的科学问题。增强的基础设施也将提供 可扩展的基础，以支持VIVA协议和数据集的持续丰富。