Common and distinct early environmental influences on cardiometabolic and respiratory health: Mechanisms and methods
Common and distinct early environmental influences on cardiometabolic and respiratory health: Mechanisms and methods
批准号:
10475628
负责人:
Emily Oken
金额:
$227.74万
依托单位国家:
美国
项目类别:
财政年份:
2016
资助国家:
美国
项目状态:
已结题
起止时间:
2016-09-21 至 2024-08-31
关键词:
AddressAdolescenceAdultAgeAir PollutionAllergensAreaAsthmaAttentionBackBehavioralBiologicalBiological MarkersBirthBostonCharacteristicsChemicalsChildChild HealthChild NutritionChildhoodChildhood AsthmaChronicCollaborationsComplexConceptionsDNA MethylationDataDevelopmentDietDyspneaEarly InterventionEnvironmentEnvironmental ExposureEnvironmental Risk FactorEtiologyEvolutionExposure toFeedbackFetusFunctional disorderGenesGeneticGoalsHealthHomeHormonesHouseholdIndividualInterventionLeadLifeLongevityMeasuresMediationMetalsMethodsModernizationModificationMothersNatureNeighborhoodsObesityOutcomeOutcome MeasurePassive SmokingPathway interactionsPatient Self-ReportPersonsPharmaceutical PreparationsPhenotypePhysical environmentPoliciesPregnancyPreventionProductivityQuality of lifeQuestionnairesResolutionRespiration DisordersRespiratory Signs and SymptomsRespiratory physiologyRiskRisk FactorsSchool-Age PopulationScienceSkinSleepSocial EnvironmentSocietiesSourceStatistical MethodsSymptomsSystemTechniquesTeenagersTestingTimeViolenceVisitairway obstructioncardiometabolismcohortcostdietaryearly adolescenceearly childhoodearly life exposureearly pregnancyeffective interventionexcessive weight gainexperiencefollow-uphealth care service utilizationinfancyinnovationinsightintervention effectmaternal depressionmodels and simulationmother nutritionmultidisciplinarynovelobesity preventionobesity-associated asthmaoffspringprenatalpreventive interventionpulmonary functionracismrecruitresiliencerespiratory healthresponsesocial stressorspatiotemporaltv watching
中文摘要
项目总结/文摘
英文摘要
Project Summary/Abstract
Obesity and asthma are the two most common chronic conditions in children. Obesity is a risk factor for
asthma as well as for dyspnea not associated with airflow obstruction. Reciprocally, asthma symptoms and
some asthma medications may increase risk of excess weight gain. Because no effective cures exist, and
because both conditions are often established before school age, early life prevention is critical. Yet our ability
to identify the most promising environmental or behavioral targets for prevention has been hampered by the
fact that many exposures may be difficult to measure, often overlap and interact, and rarely occur at a single
point in time. Individuals may vary in their sensitivity to exposures because of genetic or other factors.
Furthermore, obesity and asthma themselves are not static – each may first emerge in early childhood, later
childhood, adolescence, or adulthood; once present they may persist, remit, or worsen; and the two outcomes
may interact. Sophisticated analytic approaches are needed to handle the complex natures of both longitudinal
birth cohort data as well as of the questions themselves.
To this end, we propose this project, which is grounded in our large Boston-area Project Viva pre-birth cohort.
We recruited mothers in early pregnancy, and have followed them and their children at frequent in-person visits
(after delivery and at infancy, early childhood, mid-childhood, and the nearly completed early teen visits) as
well as via annual questionnaires. Building on the outcomes we have already assessed from birth through
early adolescence, we now propose to characterize adiposity and cardiometabolic health measures as well as
lung function and respiratory symptoms into the mid-teen years.
Using state of the art statistical methods, we will address the early life environmental exposures that, singly
and as mixtures, influence the separate and co-evolution of obesity, asthma and related dysfunctions. We will
refine exposure measures, characterize outcome trajectories, and disentangle confounding, mediation and
moderation in associations of exposures with outcomes. Finally, we will use agent based simulation models
that will draw from but also go beyond the results from our own cohort, to identify optimal levers for effective
intervention, incorporating multiple levels of action from physiologogy all the way up to policy. We will
contribute the data, measures, and methods we refine within our cohort to the larger ECHO enterprise, as well
as findings to be followed up in the large synthetic cohort with its diversity representative of children
nationwide.
期刊论文(3)
专著(0)
科研奖励(0)
会议论文
DOI:
10.1093/ajcn/nqab325
发表时间:
2022-01-11
期刊:
The American journal of clinical nutrition
影响因子:
--
作者:
[Mahmassani HA, Switkowski KM, Scott TM, Johnson EJ, Rifas-Shiman SL, Oken E, Jacques PF]
通讯作者:
Jacques PF
Fresh fish findings?
新鲜鱼的发现?
DOI:
10.1093/ajcn/nqaa249
发表时间:
2020
期刊:
The American journal of clinical nutrition
影响因子:
--
作者:
[Oken,Emily]
通讯作者:
Oken,Emily
DOI:
10.1186/s40337-022-00660-4
发表时间:
2022-09-13
期刊:
Journal of eating disorders
影响因子:
4.1
作者:
[Zhou JC, Rifas-Shiman SL, Haines J, Jones K, Oken E]
通讯作者:
Oken E
Maintain and Enrich Resource Infrastructure for Project Viva: a pre-birth cohort with follow up into adolescence
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批准号:10429909
-
项目类别:
-
资助金额:$39.86万
-
财政年份:2020
-
负责人:Emily Oken
-
依托单位:
Maintain and Enrich Resource Infrastructure for Project Viva: a pre-birth cohort with follow up into adolescence
-
批准号:10552007
-
项目类别:
-
资助金额:$39.59万
-
财政年份:2020
-
负责人:Emily Oken
-
依托单位:
Physiologic and social stressors and health during menopausal transition
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批准号:10669217
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项目类别:
-
资助金额:$37.53万
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财政年份:2020
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负责人:Emily Oken
-
依托单位:
Physiologic and social stressors and health during menopausal transition
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批准号:10424524
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项目类别:
-
资助金额:$34.4万
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财政年份:2020
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负责人:Emily Oken
-
依托单位:
Pre- and Peri-natal Predictors of Childhood Obesity
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批准号:9222311
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项目类别:
-
资助金额:$102.42万
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财政年份:2017
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负责人:Emily Oken
-
依托单位:
Longitudinal Association of PFCs with Obesity, Diabetes, and Metabolic Syndrome
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批准号:9230371
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项目类别:
-
资助金额:$35.2万
-
财政年份:2015
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负责人:Emily Oken
-
依托单位:
Patient-oriented Research in Maternal Perinatal Overnutrition and Child Adiposity
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批准号:8164496
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项目类别:
-
资助金额:$16.91万
-
财政年份:2011
-
负责人:Emily Oken
-
依托单位:
Patient-oriented Research in Maternal Perinatal Overnutrition and Child Adiposity
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批准号:8843496
-
项目类别:
-
资助金额:$16.87万
-
财政年份:2011
-
负责人:Emily Oken
-
依托单位:
Patient-oriented Research in Maternal Perinatal Overnutrition and Child Adiposity
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批准号:8463825
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项目类别:
-
资助金额:$16.89万
-
财政年份:2011
-
负责人:Emily Oken
-
依托单位:
Patient-oriented Research in Maternal Perinatal Overnutrition and Child Adiposity
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批准号:8320882
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项目类别:
-
资助金额:$16.9万
-
财政年份:2011
-
负责人:Emily Oken
-
依托单位:
Patient-oriented Research in Maternal Perinatal Overnutrition and Child Adiposity
-
批准号:8658448
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项目类别:
-
资助金额:$16.88万
-
财政年份:2011
-
负责人:Emily Oken
-
依托单位:
Effects of prenatal diet and mercury exposure on child behavior and development
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批准号:7350505
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项目类别:
-
资助金额:$34.36万
-
财政年份:2008
-
负责人:Emily Oken
-
依托单位:
Effects of prenatal diet and mercury exposure on child behavior and development
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批准号:8028380
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项目类别:
-
资助金额:$33.78万
-
财政年份:2008
-
负责人:Emily Oken
-
依托单位:
Effects of prenatal diet and mercury exposure on child behavior and development
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批准号:7600546
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项目类别:
-
资助金额:$34.39万
-
财政年份:2008
-
负责人:Emily Oken
-
依托单位:
Breastfeeding Promotion RCT and Child Metabolic Syndrome
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批准号:7599714
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项目类别:
-
资助金额:$42.09万
-
财政年份:2007
-
负责人:Emily Oken
-
依托单位:
Maternal fatty acids, birth weight and child development
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批准号:6677276
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项目类别:
-
资助金额:$13.23万
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财政年份:2003
-
负责人:Emily Oken
-
依托单位:
Maternal fatty acids, birth weight and child development
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批准号:6777619
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项目类别:
-
资助金额:$13.23万
-
财政年份:2003
-
负责人:Emily Oken
-
依托单位:
Maternal fatty acids, birth weight and child development
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批准号:7095251
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项目类别:
-
资助金额:$13.23万
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财政年份:2003
-
负责人:Emily Oken
-
依托单位:
Maternal fatty acids, birth weight and child development
-
批准号:6943376
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项目类别:
-
资助金额:$13.23万
-
财政年份:2003
-
负责人:Emily Oken
-
依托单位:
海外基金