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Common and distinct early environmental influences on cardiometabolic and respiratory health: Mechanisms and methods

早期环境对心脏代谢和呼吸系统健康的常见和独特影响：机制和方法

基本信息

批准号：
10475628
负责人：
Emily Oken
金额：
$ 227.74万
依托单位：
HARVARD PILGRIM HEALTH CARE, INC.
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-09-21 至 2024-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10475628
关键词：
Address Adolescence Adult Age Air Pollution Allergens Area Asthma Attention Back Behavioral Biological Biological Markers Birth Boston Characteristics Chemicals Child Child Health Child Nutrition Childhood Childhood Asthma Chronic Collaborations Complex Conceptions DNA Methylation Data Development Diet Dyspnea Early Intervention Environment Environmental Exposure Environmental Risk Factor Etiology Evolution Exposure to Feedback Fetus Functional disorder Genes Genetic Goals Health Home Hormones Household Individual Intervention Lead Life Longevity Measures Mediation Metals Methods Modernization Modification Mothers Nature Neighborhoods Obesity Outcome Outcome Measure Passive Smoking Pathway interactions Patient Self-Report Persons Pharmaceutical Preparations Phenotype Physical environment Policies Pregnancy Prevention Productivity Quality of life Questionnaires Resolution Respiration Disorders Respiratory Signs and Symptoms Respiratory physiology Risk Risk Factors School-Age Population Science Skin Sleep Social Environment Societies Source Statistical Methods Symptoms System Techniques Teenagers Testing Time Violence Visit airway obstruction cardiometabolism cohort cost dietary early adolescence early childhood early life exposure early pregnancy effective intervention excessive weight gain experience follow-up health care service utilization infancy innovation insight intervention effect maternal depression models and simulation mother nutrition multidisciplinary novel obesity prevention obesity-associated asthma offspring prenatal preventive intervention pulmonary function racism recruit resilience respiratory health response social stressor spatiotemporal tv watching

项目摘要

Project Summary/Abstract Obesity and asthma are the two most common chronic conditions in children. Obesity is a risk factor for asthma as well as for dyspnea not associated with airflow obstruction. Reciprocally, asthma symptoms and some asthma medications may increase risk of excess weight gain. Because no effective cures exist, and because both conditions are often established before school age, early life prevention is critical. Yet our ability to identify the most promising environmental or behavioral targets for prevention has been hampered by the fact that many exposures may be difficult to measure, often overlap and interact, and rarely occur at a single point in time. Individuals may vary in their sensitivity to exposures because of genetic or other factors. Furthermore, obesity and asthma themselves are not static – each may first emerge in early childhood, later childhood, adolescence, or adulthood; once present they may persist, remit, or worsen; and the two outcomes may interact. Sophisticated analytic approaches are needed to handle the complex natures of both longitudinal birth cohort data as well as of the questions themselves. To this end, we propose this project, which is grounded in our large Boston-area Project Viva pre-birth cohort. We recruited mothers in early pregnancy, and have followed them and their children at frequent in-person visits (after delivery and at infancy, early childhood, mid-childhood, and the nearly completed early teen visits) as well as via annual questionnaires. Building on the outcomes we have already assessed from birth through early adolescence, we now propose to characterize adiposity and cardiometabolic health measures as well as lung function and respiratory symptoms into the mid-teen years. Using state of the art statistical methods, we will address the early life environmental exposures that, singly and as mixtures, influence the separate and co-evolution of obesity, asthma and related dysfunctions. We will refine exposure measures, characterize outcome trajectories, and disentangle confounding, mediation and moderation in associations of exposures with outcomes. Finally, we will use agent based simulation models that will draw from but also go beyond the results from our own cohort, to identify optimal levers for effective intervention, incorporating multiple levels of action from physiologogy all the way up to policy. We will contribute the data, measures, and methods we refine within our cohort to the larger ECHO enterprise, as well as findings to be followed up in the large synthetic cohort with its diversity representative of children nationwide.

项目总结/文摘

项目成果

期刊论文数量（3）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Maternal diet quality during pregnancy and child cognition and behavior in a US cohort.

DOI：
10.1093/ajcn/nqab325
发表时间：
2022-01-11
期刊：
The American journal of clinical nutrition
影响因子：
0
作者：
Mahmassani HA;Switkowski KM;Scott TM;Johnson EJ;Rifas-Shiman SL;Oken E;Jacques PF
通讯作者：
Jacques PF

Fresh fish findings?

新鲜鱼的发现？