Southern California Center for Chronic Health Disparities in Latino Children and Families.

南加州拉丁裔儿童和家庭慢性健康差异中心。

• 批准号: 10437267
• 负责人: Michael Isaac Goran
• 金额: $ 505.53万
• 依托单位: CHILDREN'S HOSPITAL OF LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-24 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10437267
• 关键词: Address; Affect; Age; Air Pollution; Biometry; Birth; California; Cardiometabolic Disease; Chemical Exposure; Child; Chronic; Chronic Disease; Clinical; Collaborations; Communication; Communities; Complex; County; Data; Data Analyses; Development; Diet; Dyslipidemias; Eating Behavior; Economic Factors; Education; Elderly; Ensure; Environment; Evaluation; Factor Analysis; Family; Foundations; Funding; Generations; Goals; Government; Health; Health Food; Hispanics; Home; Household; Individual; Intervention; Language; Latino; Lead; Leadership; Life; Life Cycle Stages; Los Angeles; Mentors; Methods; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Outcome; Parents; Pediatric Hospitals; Physical activity; Pilot Projects; Play; Policies; Population; Prevalence; Prevention; Process; Randomized Clinical Trials; Research; Research Personnel; Resources; Risk Reduction; S-nitro-N-acetylpenicillamine; Science; Support System; Technical Expertise; Testing; Underrepresented Populations; Universities; base; career; clinical efficacy; cohort; community engagement; cost; cultural values; data harmonization; data management; data sharing; design; disease disparity; disorder risk; early-life nutrition; efficacy evaluation; environmental intervention; health disparity; innovation; intergenerational; literacy; multidisciplinary; non-alcoholic fatty liver disease; nutrition; obesity treatment; programs; response; social; social determinants; social factors; success; synergism; telehealth; therapy design; transmission process; treatment program; voucher

Obesity and related chronic diseases, type 2 diabetes, non-alcoholic fatty liver disease, and dyslipidemia continue to increase in the U.S., and Latinos are disproportionally affected. These disparities begin in early life, occur within families, and are driven by multi-level factors, including individual (diet, eating behaviors), social (cultural values, economic factors), and environmental (access to healthy foods, chemical exposures such as air pollution). These factors interact to affect Latino health but are rarely studied in a holistic manner. Our overarching goal is to understand how these multi-level factors contribute to multiple chronic disease disparities in Latinos across the life course, and to develop and evaluate family-based, culturally sensitive solutions. We propose to accomplish this ambitious goal by establishing the Southern California Center for Chronic Health Disparities in Latino Families and Children (SCC-CHDLFC), a coalition of academic, clinical, government, and community stakeholders across the region that is home to 10.8 million Latinos representing 45.2% of the population. The Center is led by Drs. Goran (Children’s Hospital Los Angeles; CHLA) and Baezconde-Garbanati (Univ. of Southern California; USC), who provide complementary expertise in Latino health disparities research. The Administrative Core provides leadership, oversight, communication, and evaluation to strengthen and build collaboration, accelerate research, and drive innovation to ensure Center success and impact. Project 1 (led by Dr. Goran, CHLA) utilizes an ongoing birth-cohort to examine how early-life nutrition, environment, and social factors affect chronic disease risk by age 5y, and how these factors affect response to family-based interventions in Projects 2 and 3. Project 2 (led by Dr. Boutelle, UC San Diego) tests a parent-only intervention for treatment of obesity and chronic disease risk in Latino children. The intervention, designed to address cultural issues relevant to Latino families, is delivered by telehealth to parents only, increasing dissemination potential. Project 3 (led by Dr. Cohen, Kaiser Permanente) examines the efficacy of an affordable grocery delivery program (at a cost not exceeding SNAP dollars), in conjunction with culturally appropriate meal planning, on chronic disease risk reduction in Latino multi-generation households. We will support synergy and collaboration across these projects and build the research enterprise through Center Cores. The Methods & Data Sub-Core led by Dr. Espinoza (CHLA) will provide expertise in assessment of diet, social, environmental, and geospatial factors, and data analysis and management, to support data harmonization and sharing. The Investigator Development Core led by Drs. Spruijt-Metz and de la Haye (USC) and Elder (San Diego State Univ.) will establish a mentoring network and pilot study program to support early-stage or underrepresented researchers, while also promoting team science. The Community Engagement Core led by Drs. Kipke (CHLA) and Baezconde-Garbanati (USC) engages the community in the research process via bi-directional interaction with the overall goal to accelerate the impact of Center findings on the Latino community to mitigate chronic disease risk across the region.

肥胖及相关慢性病、2型糖尿病、非酒精性脂肪肝和血脂异常 在美国继续增加，而拉丁裔则受到了严重的影响。这些差异开始在生命的早期， 发生在家庭内部，并受到多层次因素的驱动，包括个人（饮食，饮食行为），社会 （文化价值、经济因素）和环境（获得健康食品、化学品暴露，如空气 污染）。这些因素相互作用，影响拉丁美洲人的健康，但很少以整体的方式进行研究。我们 总体目标是了解这些多水平因素如何导致多种慢性病差异 在拉丁美洲人的整个生命过程中，并制定和评估以家庭为基础的，文化上敏感的解决方案。我们 我建议通过建立南加州慢性病健康中心来实现这一雄心勃勃的目标 拉丁裔家庭和儿童的差异（SCC-CHDLFC），一个学术，临床，政府， 该地区有1080万拉丁美洲人，占该地区人口的45.2%， 人口该中心由Goran博士（洛杉矶儿童医院; CHLA）和Baezconde-Garbanati博士领导 （南加州大学;南加州大学），他们在拉丁美洲健康差异研究方面提供补充专业知识。 行政核心提供领导、监督、沟通和评估，以加强和建设 协作，加速研究和推动创新，以确保中心的成功和影响。项目1（由 博士Goran，CHLA）利用一个正在进行的出生队列来研究生命早期的营养、环境和社会 影响5岁以下慢性病风险的因素，以及这些因素如何影响对基于家庭的干预措施的反应 在项目2和3中。项目2（由加州大学圣地亚哥分校的Boutelle博士领导）测试了一种仅限父母的治疗干预措施 肥胖和慢性疾病风险的关系。旨在解决文化问题的干预措施 与拉丁美洲家庭相关的远程保健服务通过远程保健仅向父母提供，增加了传播潜力。项目 3（由科恩博士领导，凯泽永久）检查了一个负担得起的杂货配送计划（在一个 费用不超过SNAP美元），结合文化上适当的膳食计划， 降低拉丁美洲多代家庭的风险。我们将支持这些领域的协同增效和合作， 项目，并通过中心核心建立研究企业。方法和数据子核心由博士领导。 埃斯皮诺萨（CHLA）将提供饮食，社会，环境和地理空间因素评估的专业知识， 数据分析和管理，以支持数据协调和共享。研究者发展 核心由Spruijt-Metz和de la Haye（南加州大学）和Elder（圣地亚哥州立大学）领导。将建立一个指导 网络和试点研究计划，以支持早期阶段或代表性不足的研究人员，同时也促进 团队科学由Kipke博士（CHLA）和Baezconde-Garbanati博士（USC）领导的社区参与核心 通过双向互动使社区参与研究过程，总体目标是加速 该中心的研究结果对拉丁裔社区的影响，以减轻整个地区的慢性病风险。