Southern California Center for Chronic Health Disparities in Latino Children and Families.

南加州拉丁裔儿童和家庭慢性健康差异中心。

• 批准号: 10656504
• 负责人: Michael Isaac Goran
• 金额: $ 486.05万
• 依托单位: CHILDREN'S HOSPITAL OF LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-24 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10656504
• 关键词: Acceleration; Address; Affect; Age; Air Pollution; Biometry; Birth; California; Cardiometabolic Disease; Chemical Exposure; Child; Chronic; Chronic Disease; Clinical; Collaborations; Communication; Communities; Complex; County; Data; Data Analyses; Development; Diet; Disparity; Dyslipidemias; Eating Behavior; Economic Factors; Education; Elderly; Ensure; Environment; Evaluation; Factor Analysis; Family; Foundations; Funding; Generations; Goals; Government; Health; Health Disparities Research; Health Food; Home; Household; Individual; Intervention; Language; Latino; Latino Population; Lead; Leadership; Life; Life Cycle Stages; Los Angeles; Mentors; Methods; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Outcome; Parents; Pediatric Hospitals; Physical activity; Pilot Projects; Policies; Population; Prevalence; Prevention; Process; Research; Research Personnel; Resources; Risk Reduction; Science; Support System; Technical Expertise; Testing; Underrepresented Populations; Universities; career; clinical efficacy; cohort; community engagement; cost; cultural values; data harmonization; data management; data sharing; design; disease disparity; disorder risk; early-life nutrition; efficacy evaluation; environmental intervention; health disparity; innovation; intergenerational; literacy; multidisciplinary; non-alcoholic fatty liver disease; nutrition; obesity treatment; programs; randomized, clinical trials; response; social; social determinants; social factors; success; synergism; telehealth; transmission process; treatment program; voucher

Obesity and related chronic diseases, type 2 diabetes, non-alcoholic fatty liver disease, and dyslipidemia continue to increase in the U.S., and Latinos are disproportionally affected. These disparities begin in early life, occur within families, and are driven by multi-level factors, including individual (diet, eating behaviors), social (cultural values, economic factors), and environmental (access to healthy foods, chemical exposures such as air pollution). These factors interact to affect Latino health but are rarely studied in a holistic manner. Our overarching goal is to understand how these multi-level factors contribute to multiple chronic disease disparities in Latinos across the life course, and to develop and evaluate family-based, culturally sensitive solutions. We propose to accomplish this ambitious goal by establishing the Southern California Center for Chronic Health Disparities in Latino Families and Children (SCC-CHDLFC), a coalition of academic, clinical, government, and community stakeholders across the region that is home to 10.8 million Latinos representing 45.2% of the population. The Center is led by Drs. Goran (Children’s Hospital Los Angeles; CHLA) and Baezconde-Garbanati (Univ. of Southern California; USC), who provide complementary expertise in Latino health disparities research. The Administrative Core provides leadership, oversight, communication, and evaluation to strengthen and build collaboration, accelerate research, and drive innovation to ensure Center success and impact. Project 1 (led by Dr. Goran, CHLA) utilizes an ongoing birth-cohort to examine how early-life nutrition, environment, and social factors affect chronic disease risk by age 5y, and how these factors affect response to family-based interventions in Projects 2 and 3. Project 2 (led by Dr. Boutelle, UC San Diego) tests a parent-only intervention for treatment of obesity and chronic disease risk in Latino children. The intervention, designed to address cultural issues relevant to Latino families, is delivered by telehealth to parents only, increasing dissemination potential. Project 3 (led by Dr. Cohen, Kaiser Permanente) examines the efficacy of an affordable grocery delivery program (at a cost not exceeding SNAP dollars), in conjunction with culturally appropriate meal planning, on chronic disease risk reduction in Latino multi-generation households. We will support synergy and collaboration across these projects and build the research enterprise through Center Cores. The Methods & Data Sub-Core led by Dr. Espinoza (CHLA) will provide expertise in assessment of diet, social, environmental, and geospatial factors, and data analysis and management, to support data harmonization and sharing. The Investigator Development Core led by Drs. Spruijt-Metz and de la Haye (USC) and Elder (San Diego State Univ.) will establish a mentoring network and pilot study program to support early-stage or underrepresented researchers, while also promoting team science. The Community Engagement Core led by Drs. Kipke (CHLA) and Baezconde-Garbanati (USC) engages the community in the research process via bi-directional interaction with the overall goal to accelerate the impact of Center findings on the Latino community to mitigate chronic disease risk across the region.

肥胖和相关慢性疾病，2型糖尿病，非酒精性脂肪肝病和血脂异常 美国继续增加，拉丁美洲人受到不成比例的影响。这些差异从早期开始， 发生在家庭中，并由多层因素驱动，包括个人（饮食，饮食行为），社会 （文化价值，经济因素）和环境（获得健康食品，化学暴露，例如空气 污染）。这些因素相互作用以影响拉丁裔健康，但很少以整体方式研究。我们的 总体目标是了解这些多层次因素如何促进多种慢性疾病分布 在整个生活课程中的拉丁美洲人，并开发和评估基于家庭的文化敏感解决方案。我们 通过建立南加州慢性健康中心来实现这一雄心勃勃的目标 拉丁裔家庭和儿童（SCC-CHDLFC）的差异，一个学术，临床，政府联盟， 该地区的社区利益相关者占有1080万拉丁美洲人，占45.2％ 人口。该中心由Drs领导。 Goran（洛杉矶儿童医院； CHLA）和Baezconde-Garbanati （南加州大学；南加州大学），他在拉丁裔健康差异研究方面提供了完整的专业知识。 行政核心提供领导，监督，沟通和评估以加强和建立 协作，加速研究并推动创新，以确保中心的成功和影响。项目1（由 CHLA的Goran博士利用正在进行的出生库来研究早期生活，环境和社会的如何 因素会影响5岁时慢性疾病的风险，以及这些因素如何影响对家庭干预的反应 在项目2和3中 拉丁裔儿童的肥胖和慢性疾病风险。干预措施旨在解决文化问题 与拉丁裔家庭有关，仅由远程医疗提供给父母，从而提高了传播潜力。项目 3（由Cohen博士领导，Kaiser Permanente）研究了负担得起的杂货交付计划的效率（在 关于慢性病 拉丁裔多代家庭的风险降低。我们将支持这些协同和协作 通过中心核心项目并建立研究企业。博士领导的方法和数据子核 Espinoza（CHLA）将提供评估饮食，社会，环境和地理空间因素的专业知识，以及 数据分析和管理，以支持数据协调和共享。研究人员开发 由Drs领导的核心。 Spruijt-Metz和de la Haye（USC）和Elder（圣地亚哥州立大学）将建立一个心理 网络和试点研究计划，以支持早期或代表性不足的研究人员，同时也促进 团队科学。由博士领导的社区参与核心。 Kipke（CHLA）和Baezconde-Garbanati（USC） 通过双向互动与社区参与研究过程，以加速加速的总体目标 中心发现对拉丁裔社区减轻该地区慢性疾病风险的影响。