Researching Institutional and Psychosocial Sources of Resiliency to Accelerated Biological Aging

A.家长助学金摘要 表观遗传学、风化、老化和居住劣势(奖励)研究的中心目标 研究(R01AG061080)旨在调查累积和背景劣势如何促进生物 老化过程。众所周知，长期暴露在这些不利条件下会通过以下方式产生健康差距 在一个称为风化的过程中的生物机制。气候变化对健康的影响一直很好- 文献[1，2]。然而，以前提出的风化机制，如不平衡载荷，缩短了 端粒长度、压力和免疫反应的改变在解释持续性健康方面已被证明是有限的。 差距[3]。人类表观遗传学的最新发现表明，生物衰老的不同速度可能 在解释这些差异方面发挥了重要作用[4，5]。R01AG061080推进了我们对 通过探索个人和空间劣势“深入皮肤”的机制来抵御风化 来抑制生物衰老过程。被称为“表观遗传时钟”的几种特定的DNA甲基化模式 已被确定为生物老化的指标[6-8]。这项奖励研究收集了DNA甲基化数据 来自威斯康星州健康调查(SHOW)的1400名参与者。生成的数据集结合了丰富的 生物标志物和人口学数据以及前沿生物老龄化参与者的住址 指标，使我们的小组能够调查生物衰老差异的社会和背景原因。 重要的是，就拟议的补编而言，该地址数据还可用于扩大 所考虑的语境特征。越来越多的跨学科证据确定了关键 当地机构环境之间的联系，如公立学校、图书馆和安全服务，以及 健康结果。据我们所知，没有一项研究调查了机构之间的联系 环境和生物老化。了解当地公共和社会机构是否以及如何影响种族， 社会经济和生物老龄化方面的差异可能为旨在 改善这些差距。我们将通过扩大生物学奖励研究的范围来解决这个问题 老龄化差距包括当地机构。我们还将评估心理社会来源的作用 在风化过程中的弹性。为了实现这些目标，我们将把公开可用的机构联系起来 数据，包括五年一次的市政和商业记录，奖励数据集使用地理编码 研究参与者的街道地址。接下来，我们将应用下面概述的分析策略来估计 当地机构、心理社会因素之间的联系--如社区意识和社区意识 参与和生物老化。Clark博士将有权访问 奖励和展示研究，以及来自人口统计中心的计算资源 健康与老龄化(CDHA)。这项建议的研究补充资料旨在促进与健康相关的多样性 研究(RSPD)将为克拉克博士提供必要的资源、保护时间和指导 完成规定的研究和培训目标。

A. SUMMARY OF PARENT GRANT The central aim of the Researching Epigenetics, Weathering, Aging, and Residential Disadvantage (REWARD) study (R01AG061080) is to investigate how cumulative and contextual disadvantage act to accelerate biological aging processes. Persistent exposure to these disadvantages is known to produce health disparities through biological mechanisms in a process known as weathering. The health effects of weathering have been well- documented [1,2]. However, previously proposed mechanisms of weathering, such as allostatic load, shortened telomere length, and altered stress and immune responses have proven limited in explaining persistent health disparities [3]. Recent discoveries in human epigenetics suggest that differential rates of biological aging may play an important role in explaining these disparities [4,5]. R01AG061080 advances our understanding of weathering by probing the mechanisms through which individual and spatial disadvantage “get under the skin” to throttle biological aging processes. Termed “epigenetic clocks,” several specific DNA methylation patterns have been identified as metrics of biological aging [6-8]. The REWARD study collected DNA methylation data from 1400 participants in the Survey of the Health of Wisconsin (SHOW). The resulting dataset combines rich biomarker and demographic data and the residential addresses of participants with cutting-edge biological aging metrics, allowing for our group to investigate social and contextual causes of disparities in biological aging. Critically for the purposes of the proposed supplement, this address data can also be used to expand the range of the contextual characteristics considered. A growing body of interdisciplinary evidence identifies key associations between local institutional contexts, such as public schools, libraries, and safety services, and health outcomes. No research of which we are aware has investigated associations between institutional contexts and biological aging. Understanding whether and how local public and social institutions shape racial, socioeconomic, and disparities in biological aging may provide new insights for structural intervention aimed at ameliorating these disparities. We will address this by expanding the reach of the REWARD study of biological aging disparities to include local institutions. We will additionally assess the role of psychosocial sources of resiliency in the weathering process. To accomplish these aims, we will link publicly available institutional data, including quinquennial municipal and business records, with the REWARD dataset using the geocoded street addresses of study participants. Next, we will apply the analytic strategy outlined below to estimate the associations between local institutions, psychosocial factors – such as sense of community and community participation, and biological aging. Dr. Clark will have access to all data resources available within the REWARD and SHOW studies, as well as computational resources from the Center for Demography of Health and Aging (CDHA). This proposed Research Supplement to Promote Diversity in Health-Related Research (RSPD) will provide Dr. Clark with the resources, protected time, and mentorship necessary to achieve the stated research and training aims.