Researching Institutional and Psychosocial Sources of Resiliency to Accelerated Biological Aging

研究加速生物衰老的复原力的制度和社会心理来源

• 批准号: 10435741
• 负责人: Michal Engelman
• 金额: $ 8.28万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-15 至 2024-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10435741
• 关键词: Address; Adult; African American; Age; Aging; Americas; Area; Attention; Awareness; Biological; Biological Aging; Biological Markers; Businesses; Censuses; Characteristics; Communities; Community Participation; DNA Methylation; Data; Data Set; Demographic Factors; Demography; Disadvantaged; Disease; Environment; Environmental Exposure; Epidemiologist; Epigenetic Process; Exhibits; Expenditure; Exposure to; Gene Expression; Geography; Government; Health; Health Surveys; Hospitals; Human; Immune response; Income; Individual; Infrastructure; Institution; Intervention; Investigation; Investments; Length; Libraries; Life Cycle Stages; Link; Longevity; Measurement; Measures; Mentorship; Methods; Municipalities; Outcome; Participant; Pathway interactions; Phenotype; Play; Police; Population; Population Study; Premature Mortality; Premature aging syndrome; Process; Psychosocial Factor; Psychosocial Influences; Public Health; Race; Records; Reporting; Research; Research Training; Resources; Role; Safety; Schools; Services; Shapes; Skin; Social Network; Socioeconomic Factors; Source; Street Address; Stress; Structure; Telomere Shortening; Time; Training; Weather; Wisconsin; age effect; aging population; allostatic load; biological adaptation to stress; career; computing resources; data resource; design; disadvantaged population; experience; fire fighter; health disparity; improved; insight; methylation pattern; mortality; neighborhood disadvantage; parent grant; population health; post-doctoral training; psychosocial; racial disparity; resilience; response biomarker; social; social disadvantage; social relationships; socioeconomic disadvantage; socioeconomic disparity

A. SUMMARY OF PARENT GRANT The central aim of the Researching Epigenetics, Weathering, Aging, and Residential Disadvantage (REWARD) study (R01AG061080) is to investigate how cumulative and contextual disadvantage act to accelerate biological aging processes. Persistent exposure to these disadvantages is known to produce health disparities through biological mechanisms in a process known as weathering. The health effects of weathering have been well- documented [1,2]. However, previously proposed mechanisms of weathering, such as allostatic load, shortened telomere length, and altered stress and immune responses have proven limited in explaining persistent health disparities [3]. Recent discoveries in human epigenetics suggest that differential rates of biological aging may play an important role in explaining these disparities [4,5]. R01AG061080 advances our understanding of weathering by probing the mechanisms through which individual and spatial disadvantage “get under the skin” to throttle biological aging processes. Termed “epigenetic clocks,” several specific DNA methylation patterns have been identified as metrics of biological aging [6-8]. The REWARD study collected DNA methylation data from 1400 participants in the Survey of the Health of Wisconsin (SHOW). The resulting dataset combines rich biomarker and demographic data and the residential addresses of participants with cutting-edge biological aging metrics, allowing for our group to investigate social and contextual causes of disparities in biological aging. Critically for the purposes of the proposed supplement, this address data can also be used to expand the range of the contextual characteristics considered. A growing body of interdisciplinary evidence identifies key associations between local institutional contexts, such as public schools, libraries, and safety services, and health outcomes. No research of which we are aware has investigated associations between institutional contexts and biological aging. Understanding whether and how local public and social institutions shape racial, socioeconomic, and disparities in biological aging may provide new insights for structural intervention aimed at ameliorating these disparities. We will address this by expanding the reach of the REWARD study of biological aging disparities to include local institutions. We will additionally assess the role of psychosocial sources of resiliency in the weathering process. To accomplish these aims, we will link publicly available institutional data, including quinquennial municipal and business records, with the REWARD dataset using the geocoded street addresses of study participants. Next, we will apply the analytic strategy outlined below to estimate the associations between local institutions, psychosocial factors – such as sense of community and community participation, and biological aging. Dr. Clark will have access to all data resources available within the REWARD and SHOW studies, as well as computational resources from the Center for Demography of Health and Aging (CDHA). This proposed Research Supplement to Promote Diversity in Health-Related Research (RSPD) will provide Dr. Clark with the resources, protected time, and mentorship necessary to achieve the stated research and training aims.

A.专利授权摘要 研究表观遗传学，风化，老化和居住劣势（奖励）的中心目标 研究（R 01 AG 061080）旨在研究累积和背景不利因素如何加速生物学 老化过程众所周知，持续暴露于这些不利因素会产生健康差异， 这是一个被称为风化的过程中的生物机制。风化对健康的影响一直很好- 记录[1，2]。然而，以前提出的风化机制，如非稳态负荷，缩短 端粒长度、压力和免疫反应的改变在解释持久健康方面被证明是有限的 差距[3]。人类表观遗传学的最新发现表明，生物衰老的不同速度可能 在解释这些差异方面发挥了重要作用[4，5]。R 01 AG 061080促进了我们对以下内容的理解： 通过探索个人和空间劣势“隐藏在皮肤下”的机制， 来抑制生物衰老过程。被称为“表观遗传时钟”的几种特定的DNA甲基化模式 已被确定为生物老化的指标[6-8]。REWARD研究收集了DNA甲基化数据 来自威斯康星州健康调查（SHOW）的1400名参与者。生成的数据集结合了丰富的 生物标志物和人口统计数据以及具有尖端生物老化的参与者的居住地址 指标，使我们的团队能够调查生物老化差异的社会和背景原因。 对于所提议的补充的目的而言，至关重要的是，该地址数据还可以用于扩展 所考虑的上下文特征。越来越多的跨学科证据确定了 地方机构环境之间的联系，如公立学校、图书馆和安全服务，以及 健康成果。据我们所知，没有研究调查过机构之间的联系， 环境和生物老化。了解当地公共和社会机构是否以及如何塑造种族， 社会经济学和生物老化的差异可能为旨在 改善这些差距。我们将通过扩大生物学研究的范围来解决这个问题。 包括地方机构在内的老龄化差距。我们还将评估心理社会来源的作用， 风化过程中的弹性。为了实现这些目标，我们将把公共可用的机构 数据，包括五年一次的市政和商业记录，以及使用地理编码的REWARD数据集 研究参与者的街道地址。接下来，我们将应用下面概述的分析策略来估计 地方机构之间的联系，社会心理因素-如社区感和社区 参与和生物老化。克拉克博士将有权访问 REWARD和SHOW研究，以及来自美国人口统计学中心的计算资源， 健康与衰老（CDHA）。这项拟议的研究补充，以促进健康相关的多样性 研究（RSPD）将为克拉克博士提供必要的资源，受保护的时间和指导， 实现既定的研究和培训目标。