Menstrual health during the Covid-19 pandemic: A longitudinal study among young people with and without endometriosis

Covid-19 大流行期间的月经健康：对患有和不患有子宫内膜异位症的年轻人进行的纵向研究

• 批准号: 10434356
• 负责人: Asgerally T. Fazleabas
• 金额: $ 27.46万
• 依托单位: MICHIGAN STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-08-01 至 2023-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10434356
• 关键词: Accounting; Administrative Supplement; Adolescence; Adolescent and Young Adult; Adult; Affect; Anxiety; COVID-19; COVID-19 pandemic; COVID-19 vaccination; Characteristics; Data; Data Collection; Disease; Distress; Economics; Enrollment; Gynecologic; Hand; Health; Home; Individual; Infection; Irregular Menstruation; Longitudinal Studies; Medical; Menorrhagia; Menstrual cycle; Menstruation; Mental Depression; Mental Health; Modification; Parents; Participant; Pelvic Pain; Pelvis; Persons; Pharmaceutical Preparations; Population; Prospective Studies; Questionnaires; Reporting; Research; Resources; SARS-CoV-2 infection; Sample Size; Sampling; Series; Severities; Social isolation; Stress; Symptoms; Testing; Time; Vaccinated; Vaccination; Woman; Women' s Health; chronic pelvic pain; cohort; coping; coping mechanism; cost; endometriosis; frailty; health care availability; human data; inflammatory marker; interest; pandemic disease; prospective; psychosocial; sample collection; social

PROJECT SUMMARY/ABSTRACT Despite prevalent anecdotal reports, the impact of SARS-CoV-2 infection or vaccination on menorrhagia and menstrual regularity remains largely undocumented and unstudied. COVID-19 disease has impacted millions, while stay-at-home orders and heightened stress have impacted billions. Menorrhagia, menstrual irregularity, and chronic pelvic pain (with or without endometriosis) are known to increase in severity when challenged with stress, unraveling of personal coping mechanisms, or diminished access to healthcare – all of which occurred during the COVID-19 pandemic. To successfully assess changes in menstrual and gynecologic characteristics attributable to SARS-CoV-2 infection or vaccination, it is critical to compare post-infection or post-vaccination menstruation and pelvic symptoms to that person’s pre-exposure menstruation and also to compare menstruation among those who have been infected or vaccinated to those who have not, accounting for pandemic impacts that may vary by individual social or economic frailty and mental health. Answering these critical questions with scientific rigor in existing research cohort populations is responsive to Notice of Special Interest (NOSI) to Encourage Administrative Supplement Applications to Investigate COVID-19 Vaccination and Menstruation (NOT-HD-21-035). We will utilize an ongoing prospective study, the Women’s Health Study: from Adolescence to Adulthood (A2A, N=1569) - the core cohort included in the Parent R01 (HD094842). Cohort participants have completed annual questionnaires since enrollment began in 2012, which includes assessment of menstrual characteristics. Leveraging this cohort to compare and contrast prospectively collected pre-, peri-, and post-pandemic characteristics and inflammatory markers, we will test these hypotheses: a) SARS-CoV-2 infection is associated with incident or worsened menorrhagia, menstrual irregularity or pelvic pain compared to pre-pandemic and pre-infection menstrual characteristics within individual women, and compared to women who have not been infected; b) SARS-CoV-2 vaccination is associated with incident or worsened menorrhagia, menstrual irregularity or pelvic pain, as has been reported anecdotally, compared to pre-vaccination menstrual characteristics within individuals, and compared to unvaccinated women; and c) Increase in COVID-19 pandemic-related distress (e.g. depression, anxiety, social isolation, economic peril) and diminished healthy coping will be associated with incident or increased severity of menorrhagia, menstrual cycle irregularity, or chronic pelvic pain – independent of SARS-CoV-2 infection or vaccination. While many are scrambling to assemble research teams and establish de novo human data and sample collection, which will yield uncertain deliverables, small samples sizes, and often reliance on fully de-identified samples from which confounding and modification cannot be validly assessed, the proposed study capitalizes on well-established resources providing cost and time efficiency as well as scientifically robust opportunity.

项目总结/摘要 尽管有流行的轶事报道，但SARS-CoV-2感染或疫苗接种对月经过多和 月经规律在很大程度上仍没有文献记载和研究。COVID-19疾病影响了数百万人， 而留在家里的订单和压力的增加影响了数十亿人。月经过多，月经不调， 和慢性盆腔疼痛（有或没有子宫内膜异位症）是已知的严重程度增加时，挑战与 压力，个人应对机制的瓦解，或获得医疗保健的机会减少-所有这些都发生在 在COVID-19大流行期间。成功评估月经和妇科特征的变化 由于SARS-CoV-2感染或疫苗接种，比较感染后或疫苗接种后 月经和盆腔症状，以该人的前暴露月经，也比较 月经在那些谁已感染或接种疫苗的人谁没有，占 流行病的影响可能因个人的社会或经济脆弱性和心理健康而异。回答这些 在现有研究队列人群中具有科学严谨性的关键问题是对特别通知的响应。 NOSI鼓励行政补充申请调查COVID-19疫苗接种， 月经（NOT-HD-21-035）。我们将利用正在进行的前瞻性研究，妇女健康研究：从 青少年至成年期（A2 A，N=1569）-母研究R 01（HD 094842）中包含的核心队列。队列 自2012年开始招募以来，参与者已经完成了年度问卷，其中包括评估 月经的特点。利用该队列比较和对比前瞻性收集的术前、术后、 和大流行后的特征和炎症标志物，我们将测试这些假设：a）SARS-CoV-2 感染与月经过多、月经不规则或盆腔疼痛的发生或恶化有关， 个别妇女在大流行前和感染前的月经特征，并与 未被感染; B）SARS-CoV-2疫苗接种与月经过多事件或恶化有关， 与接种前月经不调或盆腔疼痛相比， 个体内的特征，并与未接种疫苗的女性相比;以及c）COVID-19的增加 与流行病有关的痛苦（例如抑郁、焦虑、社会孤立、经济危险）和健康状况下降 应对将与月经过多、月经周期不规则或 慢性盆腔疼痛-与SARS-CoV-2感染或疫苗接种无关。虽然许多人争先恐后地 组建研究团队，重新建立人类数据和样本收集，这将产生不确定的 可交付成果、样本量小，并且通常依赖于完全去识别的样本， 修改不能有效地评估，拟议的研究利用了完善的资源， 成本和时间效率以及科学上的强大机会。