Computed Tomographic Insights Into Pulmonary Hypertension
Computed Tomographic Insights Into Pulmonary Hypertension
批准号:
10439060
负责人:
FARBOD Nicholas RAHAGHI
金额:
$7.07万
依托单位国家:
美国
项目类别:
财政年份:
2017
资助国家:
美国
项目状态:
已结题
起止时间:
2017-06-01 至 2023-11-30
关键词:
3-DimensionalAlgorithmsBiomedical EngineeringBlood VesselsBlood coagulationChestChronic Obstructive Airway DiseaseClinicalCollaborationsComplicationComputational algorithmComputersCritical CareDataDedicationsDiseaseDisease ProgressionDistalDoctor of PhilosophyEarly DiagnosisEventExerciseFundingHeart DiseasesHeart failureHospitalsImageKnowledgeLaboratoriesLeftLifeLungLung diseasesMechanicsMedicalMedicineMentorsMorbidity - disease rateOutcomePatientsPharmaceutical PreparationsPhysiciansPhysicsPublicationsPulmonary HypertensionResearch DesignRestRight Ventricular DysfunctionScienceScientistSeverity of illnessSignal TransductionSiteStructureSupervisionTeaching HospitalsTraining ProgramsUnited States National Institutes of HealthWestern WorldWomanWorkX-Ray Computed Tomographyaggressive therapycare outcomescohortcomorbidityengineering designheart functionimage processingimprovedinsightlung imagingmedical schoolsmembermortalityradiologistreconstructionscreening
中文摘要
项目摘要
肺动脉高压是一种最常见的并发症,
在西方世界,慢性阻塞性肺病、心力衰竭和肺部血块是常见的慢性病。它的存在本身或
与其他病症结合导致显著的发病率和死亡率。开发的药物
成功治疗I组疾病在II组(由于左心脏病)中没有显示出同样多的效用,
III组(由于肺部疾病)PH。有人提出,这可能是由于无法识别
对这种治疗有反应的PH亚型。此外,非侵入性筛查和早期检测
保持挑战性。放射科医生一直在观察远端脉管系统的损失(修剪),
增加血管“迂曲度”和肺血管的近端扩张。开发的算法和
由Rahaghi博士和应用胸部成像实验室(ACIL)小组实施的3D
使用CT扫描重建和量化肺血管结构。Rahaghi博士
已经在多个群组中部署了这些算法,生成了出版物和初步数据。
在他的第一个目标中,Rahaghi博士将探索肺血管结构的差异
不同肺动脉高压组与非肺动脉高压组之间的差异及相关性
这些发现与疾病的严重程度有关。在第二个目标中,他将研究肺血管
结构可以预测右心室功能障碍,这是疾病进展中的一个关键事件,
结果不佳,表明需要更积极的治疗。在第三个目标中,他将研究肺
运动时肺血管结构及其与肺血管力学的关系。
这项工作将在布里格姆的肺部和重症监护医学部进行,
女子医院是哈佛医学院的核心教学医院,在两位导师的监督下,
博士Washko博士是临床肺部成像专家,Waxman博士是临床肺部成像专家。
高血压该网站是美国国家卫生研究院资助的PVDOMICS项目的六个网站之一
努力分型肺动脉高压。Rahaghi博士的团队包括应用胸部成像的成员
该实验室包括一个由数学家和计算机科学家组成的团队,
合作创建用于肺部图像处理的计算机算法。
Rahaghi博士毕生致力于成为一名专注于定量研究的物理科学家。
科学及其在医学上的应用。他有物理学背景和博士学位。生物工程作为
是NIH资助的医学科学家培训项目的一部分。他计划利用他所获得的知识,
与患有肺动脉高压的患者以及他的工程和研究设计知识进行互动
以改善PH的护理和结果。
英文摘要
Project Summary
Pulmonary hypertension is a disease that occurs most frequently as complicating comorbidity of very common
disease in the western world including COPD, Heart Failure and Blood Clots in the lung. Its presence alone or
in combination with other conditions leads to significant morbidity and mortality. Medications developed
successfully for Group I disease have not shown as much utility in Group II (Due to left heart disease) and
Group III (due to lung disease) PH. It has been proposed that this may be due to an inability to identify
subtypes of PH that respond to this type of treatment. Additionally, non-invasive screening and early detection
remain challenging. Radiologists have been making observations of the loss of distal vasculature (pruning),
increase vascular “tortuosity”, and proximal dilation of the pulmonary vasculature. Algorithms developed and
implemented by Dr. Rahaghi and the Applied Chest Imaging Laboratory (ACIL) group permit the 3D
reconstruction and quantification of the structure of pulmonary vasculature using CT scans. Dr. Rahaghi has
already deployed these algorithms in multiple cohorts generating publications and preliminary data.
In his first aim, Dr. Rahaghi will explore the differences in the structure of the pulmonary vasculature
between different groups of pulmonary hypertension and subjects without pulmonary hypertension and relate
these findings to disease severity. In the second aim, he will study the extent to which pulmonary vascular
structure can predict right ventricular dysfunction, a key event in the progression of disease that is predictive of
poor outcome and signals the need for more aggressive treatment. In the third aim, he will study pulmonary
vascular structure and its relationship to pulmonary vascular mechanics during exercise.
This work will be performed at the Division of Pulmonary and Critical Care Medicine at Brigham and
Women's Hospital, a core teaching hospital of Harvard Medical School, under the supervision of two mentors,
Dr. Washko who is an expert in clinical lung imaging and Dr. Waxman who is an expert in clinical pulmonary
hypertension. The site is one of six in the nation chosen as part of the PVDOMICS project which is NIH funded
effort to subtype pulmonary hypertension. Dr. Rahaghi's team includes members of the Applied Chest Imaging
Laboratory which includes a team of mathematicians and computer scientists who have a decade long
collaboration in creating computer algorithms for image-processing of the lung.
Dr. Rahaghi has a life-long dedication to becoming a physician-scientist with a focus on quantitative
sciences and their applications to medicine. He has a background in physics and a Ph.D. in Bioengineering as
part of a NIH sponsored medical-scientist training program. He plans to use the knowledge he gains by
interacting with patients who have pulmonary hypertension and his knowledge of engineering and study design
to improve care and outcomes in PH.
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DOI:
10.1007/s00421-018-3873-4
发表时间:
2018-07
期刊:
European journal of applied physiology
影响因子:
3
作者:
[McCabe C, Oliveira RKF, Rahaghi F, Faria-Urbina M, Howard L, Axell RG, Priest AN, Waxman AB, Systrom DM]
通讯作者:
Systrom DM
Automated CT-Based Quantification of Pulmonary Veins Shows Greater Central Venous Dilation in Group 2 Pulmonary Hypertension Compared With Group 1 Pulmonary Arterial Hypertension and Control Subjects.
基于 CT 的肺静脉自动定量显示,与第 1 组肺动脉高压受试者和对照受试者相比,第 2 组肺动脉高压受试者的中心静脉扩张更大。
DOI:
10.1016/j.chpulm.2023.100020
发表时间:
2023
期刊:
CHEST pulmonary
影响因子:
--
作者:
[Synn,AndrewJ, Harder,EileenM, Nardelli,Pietro, Ross,JamesC, Maron,BradleyA, Leopold,JaneA, Waxman,AaronB, SanJoséEstépar,Raúl, Washko,GeorgeR, Rahaghi,FarbodN]
通讯作者:
Rahaghi,FarbodN
Cardiac Morphometry on Computed Tomography and Exacerbation Reduction with β-Blocker Therapy in Chronic Obstructive Pulmonary Disease.
计算机断层扫描的心脏形态测量和慢性阻塞性肺疾病β-受体阻滞剂治疗减轻病情加重。
DOI:
10.1164/rccm.201702-0399le
发表时间:
2017
期刊:
American journal of respiratory and critical care medicine
影响因子:
24.7
作者:
[Bhatt,SuryaP, Vegas-Sánchez-Ferrero,Gonzalo, Rahaghi,FarbodN, MacLean,ErickS, Gonzalez-Serrano,German, Come,CarolynE, Kinney,GregoryL, Hokanson,JohnE, Budoff,MatthewJ, Cuttica,MichaelJ, Wells,JMichael, Estépar,RaúlSanJosé, Washko,G]
通讯作者:
Washko,G
DOI:
10.1177/20458940211040713
发表时间:
2021-07
期刊:
Pulmonary circulation
影响因子:
2.6
作者:
[Sweatt AJ, Reddy R, Rahaghi FN, Al-Naamani N, American Thoracic Society Pulmonary Circulation Assembly Early Career Working Group]
通讯作者:
American Thoracic Society Pulmonary Circulation Assembly Early Career Working Group
Pulmonary arterial pruning is associated with CT-derived bronchiectasis progression in smokers.
肺动脉修剪与吸烟者 CT 衍生的支气管扩张进展相关。
DOI:
10.1016/j.rmed.2022.106971
发表时间:
2022
期刊:
Respiratory medicine
影响因子:
4.3
作者:
[Dolliver,WojciechR, Wang,Wei, Nardelli,Pietro, Rahaghi,FarbodN, Orejas,JoseL, Maselli,DiegoJ, Yen,Andrew, Young,Kendra, Kinney,Gregory, Estépar,RaulSanJosé, Diaz,AlejandroA]
通讯作者:
Diaz,AlejandroA
共 7 条
Classification and Prognostication in Pulmonary Thromboembolism Using Computed Tomography Image Analytics
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批准号:10502716
-
项目类别:
-
资助金额:$76.87万
-
财政年份:2022
-
负责人:FARBOD Nicholas RAHAGHI
-
依托单位:
Computed Tomographic Insights Into Pulmonary Hypertension
-
批准号:10162641
-
项目类别:
-
资助金额:$19.98万
-
财政年份:2017
-
负责人:FARBOD Nicholas RAHAGHI
-
依托单位:
海外基金