Beyond the Medical: The ELSI of Polygenic Scores for Social Traits

超越医学:社会特征多基因评分的 ELSI

基本信息

项目摘要

7. PROJECT SUMMARY/ ABSTRACT In traditional predictive genetic testing single gene variants are analyzed to determine whether an individual is at high risk of developing a disease. The vast majority of diseases, however, are polygenic—caused by many different genes. Polygenic risk scores (PRS) have been heralded for their promise to predict risk for these more complex diseases like heart disease or diabetes by measuring the contribution of hundreds or thousands of genetic variants at once. Yet beyond prediction of health or medical outcomes, the realm of `sociogenomics' is developing polygenic scores (PGS) measuring genetic contributions to social traits and behavioral factors, such as income, educational attainment, sexuality, and optimism. Proponents of sociogenomic PGS cite the potential for this research to increase understanding of the interplay between genetic and environmental factors, to account for genetic factors in social science research, and to create personalized social interventions akin to personalized medicine. But others worry that sociogenomic PGS findings could lead to discrimination and an exacerbation of existing social disparities. In order to understand the ethical, legal, and social implications of sociogenomic PGS research and its outcomes, this project addresses the following research questions: 1) What are the current trends in the development of sociogenomic PGS and what are the possible applications of scores in social settings?; 2) How do various stakeholders perceive the benefits and risks of sociogenomic PGS?; and 3) How well do existing laws, policies, or governance protect against the potential harms of sociogenomic PGS while also promoting their potential benefits? Answering these questions requires both empirical research and legal analysis. Using horizon scanning methodologies, Aim 1 maps the landscape of sociogenomic PGS, their potential applications, and how sociogenomic research findings are presented to and consumed by the public. Aim 2 enlists those involved in the pipeline of sociogenomics research (biobank participants whose genetic data may be used to develop PGS, PGS researchers who develop the scores, and social scientists who may use the scores in their research studies) to examine and assess their attitudes toward the range of harms and benefits of sociogenomic PGS, and the implications of varying applications of PGS. Both of these efforts will inform Aim 3, which consists of a legal and policy analysis of how current legal rules protect against potential misuse and/or promote possible benefits of sociogenomic findings. The product of this project will be a set of case studies designed to help policy makers and researchers anticipate and mitigate the potential harms of employing sociogenomic PGS in various social settings while still identifying and maximizing potential benefits.
7. 项目摘要/摘要

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Rosemary Jean Cadigan其他文献

Rosemary Jean Cadigan的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Rosemary Jean Cadigan', 18)}}的其他基金

Beyond the Medical: The ELSI of Polygenic Scores for Social Traits
超越医学:社会特征多基因评分的 ELSI
  • 批准号:
    10644015
  • 财政年份:
    2022
  • 资助金额:
    $ 71.15万
  • 项目类别:
Incidental Enhancement: Addressing a Neglected Policy Issue in Human Genome Editing
附带增强:解决人类基因组编辑中被忽视的政策问题
  • 批准号:
    10565919
  • 财政年份:
    2020
  • 资助金额:
    $ 71.15万
  • 项目类别:
Incidental Enhancement: Addressing a Neglected Policy Issue in Human Genome Editing
附带增强:解决人类基因组编辑中被忽视的政策问题
  • 批准号:
    10363704
  • 财政年份:
    2020
  • 资助金额:
    $ 71.15万
  • 项目类别:

相似海外基金

STTR Phase I: A Reliable and Efficient New Method for Satellite Attitude Control
STTR第一阶段:可靠、高效的卫星姿态控制新方法
  • 批准号:
    2310323
  • 财政年份:
    2024
  • 资助金额:
    $ 71.15万
  • 项目类别:
    Standard Grant
BCSER - PVEST: A Dynamic Framework for Investigating STEM Interest, Attitude and Identity Among African American Middle School Students
BCSER - PVEST:调查非裔美国中学生 STEM 兴趣、态度和身份的动态框架
  • 批准号:
    2327055
  • 财政年份:
    2023
  • 资助金额:
    $ 71.15万
  • 项目类别:
    Standard Grant
The hidden power of grammar: a mixed-methods study of media discourses on climate change protests and their effects on audience attitude.
语法的隐藏力量:气候变化抗议媒体话语及其对受众态度影响的混合方法研究。
  • 批准号:
    2881735
  • 财政年份:
    2023
  • 资助金额:
    $ 71.15万
  • 项目类别:
    Studentship
Development of Psychological Approach to Improve Intergroup Attitude and Behavior and Exploration of Its Application
改善群际态度和行为的心理学方法的发展及其应用探索
  • 批准号:
    23K12855
  • 财政年份:
    2023
  • 资助金额:
    $ 71.15万
  • 项目类别:
    Grant-in-Aid for Early-Career Scientists
Attitude and Identity in Wales' Primary and Secondary Schools
威尔士中小学的态度和认同
  • 批准号:
    2876788
  • 财政年份:
    2023
  • 资助金额:
    $ 71.15万
  • 项目类别:
    Studentship
Attitude and Shape Estimation of an Unknown Object Using Light Curves
使用光曲线估计未知物体的姿态和形状
  • 批准号:
    23K04232
  • 财政年份:
    2023
  • 资助金额:
    $ 71.15万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Examining the relationship between death attitude and AD completion and attitude among older Chinese Americans
研究老年华裔美国人的死亡态度与 AD 完成度和态度之间的关系
  • 批准号:
    10575699
  • 财政年份:
    2023
  • 资助金额:
    $ 71.15万
  • 项目类别:
Insect flight mechanisms in high flight attitude
高飞行姿态下昆虫的飞行机制
  • 批准号:
    22H01397
  • 财政年份:
    2022
  • 资助金额:
    $ 71.15万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
High-accurate relative position and rotation control of multiple satellites considering orbit-attitude coupled dynamics for space interferometry
空间干涉测量中考虑轨道姿态耦合动力学的多卫星高精度相对位置和旋转控制
  • 批准号:
    22K18856
  • 财政年份:
    2022
  • 资助金额:
    $ 71.15万
  • 项目类别:
    Grant-in-Aid for Challenging Research (Exploratory)
Solar Sailing: Attitude, Orbit, and Shape Control
太阳航行:姿态、轨道和形状控制
  • 批准号:
    RGPIN-2020-04037
  • 财政年份:
    2022
  • 资助金额:
    $ 71.15万
  • 项目类别:
    Discovery Grants Program - Individual
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了