How do cells sense and react to mechanical forces?

细胞如何感知机械力并做出反应？

• 批准号: DE210100604
• 负责人: Dr Sarah Boyle
• 金额: $ 30.71万
• 依托单位: University of South Australia
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Early Career Researcher Award
• 财政年份: 2022
• 资助国家: 澳大利亚
• 起止时间: 2022-03-16 至 2025-12-15
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DE210100604
• 关键词: How; do; cells; sense; react

There is accumulating evidence that mechanical forces exerted on tissues and cells strongly influences their behaviour. My research aims to understand how cells sense and respond to forces experienced throughout life. Using a combination of three-dimensional cell and tissue culture methods, I will investigate how compressive forces change the biochemistry of cells and their functionality. This work is aimed at generating fundamental knowledge to improve our comprehension of how cells respond to force. The expected outcome is a greater understanding of mechanical and biochemical relationships between cells and the environment, to inform fields of tissue engineering of culture scaffolds to better mimic natural cell-tissue settings.

越来越多的证据表明，施加在组织和细胞上的机械力会强烈地影响它们的行为。我的研究旨在了解细胞如何感知和应对生命中所经历的力量。使用三维细胞和组织培养方法的组合，我将研究压缩力如何改变细胞的生物化学及其功能。这项工作的目的是产生基础知识，以提高我们对细胞如何对力作出反应的理解。预期的结果是更好地理解细胞与环境之间的机械和生化关系，为培养支架的组织工程领域提供信息，以更好地模拟自然细胞组织环境。