Yale Alzheimer Disease Research Center

项目摘要：耶鲁 ADRC 整体 耶鲁大学阿尔茨海默病研究中心 (ADRC) 致力于增进我们对 细胞生物学水平的阿尔茨海默病，最终目标是将实验室发现转化为 新颖有效的临床疗法。七个核心（管理、临床、数据、生物标志物、神经病理学、 成像和外展）和研究教育部分将共同努力实现这一目标。我们的 统一的主题是关注特定神经元的细胞生物学及其对 AD 的破坏，无论是通过 生物流体中的基因组/蛋白质组方法，诊断成像，临床表现在行为上 尸检时在脑组织中病理学检测到的属性，或在诱导多能干细胞培养物中观察到的属性 细胞。七大核心的参与将加速和优化个体研究能力 耶鲁大学 ADRC 内部和外部的项目提出并回答特定的病理生理学问题 将知识转化为疗法。对特定项目的核心支持的广度将允许 对阿尔茨海默病异质性的评估。 耶鲁大学 ADRC 希望扩大其促进专注于特定领域的研究项目的记录 利用人体组织时，神经元细胞器和特定神经元亚型在疾病中受到干扰 分析和人体成像来评估机制假设。生物标记核心将开发 新颖、灵敏、高通量的质谱分析和基因组甲基化谱来监测 疾病机制。成像核心将开发、集成和应用新型 PET 示踪剂和功能 MRI 连接映射到临床核心和多个单独支持的研究项目的主题。一个 重点是将研究成果转化为治疗效益。支持 作为阿尔茨海默病研究的未来优势，耶鲁大学 ADRC 将努力促进年轻人的职业发展 调查人员通过杰出的内部咨询委员会的指导，并通过发展 项目奖项加上研究教育开发的广泛教育计划 组件。除了收集脑、脑脊液、DNA、血清、血细胞的临床数据和生物样本 和 iPSC 供耶鲁 ADRC 研究团队成员进行分析，耶鲁 ADRC 将支持其他 NIH- 资助相关主题的研究，并为国家 NIA 资助的国家研究贡献材料 网络。外展核心将与社区联系，提供更多关于 阿尔茨海默病和相关痴呆症。

PROJECT SUMMARY: OVERALL YALE ADRC The Yale Alzheimer’s Disease Research Center (ADRC) seeks to advance our understanding of Alzheimer’s disease at a cell biological level with the eventual goal of translating laboratory discoveries into novel effective clinical therapies. Seven Cores (Administrative, Clinical, Data, Biomarker, Neuropathology, Imaging and Outreach) and a Research Education Component will work together to achieve this goal. Our unifying theme is a focus on the cell biology of specific neurons, and its disruption in AD, whether measured by genome/proteome-wide methods in Biofluids, imaged diagnostically, manifested clinically in behavioral attributes, detected pathologically in brain tissue at autopsy or observed in cultures of induced pluripotent stem cells. The participation of the seven Cores will accelerate and optimize the ability of individual Research Projects both within and beyond the Yale ADRC to ask and answer specific pathophysiological questions and to translate knowledge to therapies. The breadth of the Core support for particular projects will allow assessments across the heterogeneity of Alzheimer’s disease. The Yale ADRC expects to extend its track record of facilitating Research Projects focused on specific neuronal organelles and specific neuronal subtypes perturbed in disease while making use of human tissue analysis and human subject imaging to evaluate mechanistic hypotheses. The Biomarker Core will develop novel, sensitive and high-throughput mass spectrometry assays and genomic methylation profiles to monitor disease mechanisms. The Imaging Core will develop, integrate and apply novel PET tracers and functional MRI connectivity maps to subjects of the Clinical Core and multiple separately supported Research Projects. A key emphasis will be the translational development of research findings into therapeutic benefit. To support the future strength of Alzheimer’s research, the Yale ADRC will strive to advance the careers of Young Investigators through mentorship from a distinguished Internal Advisory Committee, and through Development Project awards coupled with an extensive educational program developed by the Research Education Component. In addition to collecting clinical data and biospecimens of brain, CSF, DNA, serum, blood cells and iPSCs for analysis by members of the Yale ADRC research team, the Yale ADRC will support other NIH- funded research studies on related topics and contribute materials to national NIA-sponsored research networks. The Outreach Core will connect with the community to provide greater knowledge regarding Alzheimer’s disease and related dementia.