Yale Alzheimer Disease Research Center

耶鲁大学阿尔茨海默病研究中心

• 批准号: 10620812
• 负责人: STEPHEN M STRITTMATTER
• 金额: $ 318.24万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-06-15 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10620812
• 关键词: Acceleration; Advisory Committees; Alzheimer' s Disease; Alzheimer' s disease related dementia; Area; Autopsy; Award; Axonal Transport; Back; Behavioral; Biological; Biological Assay; Biological Markers; Blood Cells; Brain; Career Mobility; Caregiver support; Cells; Cellular biology; Clinic; Clinical; Clinical Data; Clinical Trials; Collaborations; Communities; Connecticut; Coupled; DNA; Data; Data Collection; Data Set; Development; Dimensions; Disease; Education; Education and Outreach; Evaluation; Faculty; Family; Fostering; Functional Magnetic Resonance Imaging; Funding; Future; Genome; Genomics; Gerontology; Goals; Heterogeneity; Hospitals; Image; Impaired cognition; Individual; Intention; Intervention; Investigation; Knowledge; Laboratories; Laboratory Research; Leadership; Learning; Life; Ligands; Lysosomes; Maps; Mass Spectrum Analysis; Measures; Memory Disorders; Mentors; Mentorship; Methodology; Methods; Methylation; Minority; Modification; Molecular; Molecular Analysis; Monitor; Nerve Degeneration; Neurology; Neuronal Dysfunction; Neurons; Neuropsychology; Neurosciences; Organelles; Pathologic; Pathway interactions; Pharmacology; Phase; Play; Population; Positron-Emission Tomography; Postdoctoral Fellow; Proteome; Recording of previous events; Records; Research; Research Personnel; Research Project Grants; Research Support; Resources; Rest; Role; Serum; Signal Transduction; Site; Specimen; Synapses; Testing; Therapeutic; Tracer; Training; Translating; Translational trial; Translations; United States National Institutes of Health; Vocational Guidance; Whole Blood; Work; bench to bedside; brain tissue; career; career development; clinical care; cohort; data management; doctoral student; education research; epigenomics; ethnic diversity; family burden; graduate student; human subject; human tissue; induced pluripotent stem cell; kinase inhibitor; member; neuropathology; novel; outreach; postsynaptic; programs; recruit; repaired; research and development; research study; sample collection; statistics; success; therapeutic development; transcriptomics

PROJECT SUMMARY: OVERALL YALE ADRC The Yale Alzheimer’s Disease Research Center (ADRC) seeks to advance our understanding of Alzheimer’s disease at a cell biological level with the eventual goal of translating laboratory discoveries into novel effective clinical therapies. Seven Cores (Administrative, Clinical, Data, Biomarker, Neuropathology, Imaging and Outreach) and a Research Education Component will work together to achieve this goal. Our unifying theme is a focus on the cell biology of specific neurons, and its disruption in AD, whether measured by genome/proteome-wide methods in Biofluids, imaged diagnostically, manifested clinically in behavioral attributes, detected pathologically in brain tissue at autopsy or observed in cultures of induced pluripotent stem cells. The participation of the seven Cores will accelerate and optimize the ability of individual Research Projects both within and beyond the Yale ADRC to ask and answer specific pathophysiological questions and to translate knowledge to therapies. The breadth of the Core support for particular projects will allow assessments across the heterogeneity of Alzheimer’s disease. The Yale ADRC expects to extend its track record of facilitating Research Projects focused on specific neuronal organelles and specific neuronal subtypes perturbed in disease while making use of human tissue analysis and human subject imaging to evaluate mechanistic hypotheses. The Biomarker Core will develop novel, sensitive and high-throughput mass spectrometry assays and genomic methylation profiles to monitor disease mechanisms. The Imaging Core will develop, integrate and apply novel PET tracers and functional MRI connectivity maps to subjects of the Clinical Core and multiple separately supported Research Projects. A key emphasis will be the translational development of research findings into therapeutic benefit. To support the future strength of Alzheimer’s research, the Yale ADRC will strive to advance the careers of Young Investigators through mentorship from a distinguished Internal Advisory Committee, and through Development Project awards coupled with an extensive educational program developed by the Research Education Component. In addition to collecting clinical data and biospecimens of brain, CSF, DNA, serum, blood cells and iPSCs for analysis by members of the Yale ADRC research team, the Yale ADRC will support other NIH- funded research studies on related topics and contribute materials to national NIA-sponsored research networks. The Outreach Core will connect with the community to provide greater knowledge regarding Alzheimer’s disease and related dementia.

项目总结：整体耶鲁大学adrc

项目成果

Emotion Processing Dysfunction in Alzheimer's Disease: An Overview of Behavioral Findings, Systems Neural Correlates, and Underlying Neural Biology.

• DOI: 10.1177/15333175221082834
• 发表时间: 2022-01
• 期刊: AMERICAN JOURNAL OF ALZHEIMERS DISEASE AND OTHER DEMENTIAS
• 影响因子: 3.4
• 作者: Chaudhary, Shefali;Zhornitsky, Simon;Chao, Herta H.;van Dyck, Christopher H.;Li, Chiang-Shan R.
• 通讯作者: Li, Chiang-Shan R.

Evaluating the Safety and Efficacy of Crenezumab vs Placebo in Adults With Early Alzheimer Disease: Two Phase 3 Randomized Placebo-Controlled Trials.

• DOI: 10.1001/jamaneurol.2022.2909
• 发表时间: 2022-11-01
• 期刊: JAMA NEUROLOGY
• 影响因子: 29
• 作者: Ostrowitzki, Susanne;Bittner, Tobias;Sink, Kaycee M.;Mackey, Howard;Rabe, Christina;Honig, Lawrence S.;Cassetta, Emanuele;Woodward, Michael;Boada, Merce;van Dyck, Christopher H.;Grimmer, Timo;Selkoe, Dennis J.;Schneider, Andres;Blondeau, Kathleen;Hu, Nan;Quartino, Angelica;Clayton, David;Dolton, Michael;Dang, Yifan;Ostaszewski, Beth;Sanabria-Bohorquez, Sandra M.;Rabbia, Michael;Toth, Balazs;Eichenlaub, Udo;Smith, Jillian;Honigberg, Lee A.;Doody, Rachelle S.
• 通讯作者: Doody, Rachelle S.

Cerebral Volumetric Correlates of Apathy in Alzheimer's Disease and Cognitively Normal Older Adults: Meta-Analysis, Label-Based Review, and Study of an Independent Cohort.

• DOI: 10.3233/jad-215316
• 发表时间: 2022
• 期刊: JOURNAL OF ALZHEIMERS DISEASE
• 影响因子: 4
• 作者: Chaudhary, Shefali;Zhornitsky, Simon;Chao, Herta H.;van Dyck, Christopher H.;Li, Chiang-Shan R.
• 通讯作者: Li, Chiang-Shan R.

Spreading of Alzheimer tau seeds is enhanced by aging and template matching with limited impact of amyloid-β.

• DOI: 10.1016/j.jbc.2021.101159
• 发表时间: 2021-10
• 期刊: The Journal of biological chemistry
• 作者: Nies SH;Takahashi H;Herber CS;Huttner A;Chase A;Strittmatter SM
• 通讯作者: Strittmatter SM

Cognitive impairment in pulmonary arterial hypertension.

• DOI: 10.1002/acn3.51867
• 发表时间: 2023-10
• 期刊: ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
• 影响因子: 5.3
• 作者: Heller, Sloane;See, Claudia;Singh, Inderjit;Fredericks, Carolyn A.
• 通讯作者: Fredericks, Carolyn A.