Yale Alzheimer Disease Research Center

耶鲁大学阿尔茨海默病研究中心

• 批准号: 9921654
• 负责人: STEPHEN M STRITTMATTER
• 金额: $ 320.6万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-06-15 至 2025-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9921654
• 关键词: Address; Advisory Committees; Alzheimer' s Disease; Alzheimer' s disease related dementia; Area; Autopsy; Award; Axonal Transport; Back; Behavioral; Biological; Biological Assay; Biological Markers; Blood Cells; Brain; Career Mobility; Caregiver support; Cells; Cellular biology; Clinic; Clinical; Clinical Data; Clinical Trials; Collaborations; Communities; Connecticut; Coupled; DNA; Data; Data Collection; Data Set; Dementia; Development; Diagnostic Imaging; Disease; Education and Outreach; Evaluation; Faculty; Family; Fostering; Functional Magnetic Resonance Imaging; Funding; Future; Genome; Genomics; Gerontology; Goals; Heterogeneity; Hospitals; Image; Impaired cognition; Individual; Intention; Intervention; Investigation; Knowledge; Laboratories; Laboratory Research; Leadership; Learning; Life; Ligands; Lysosomes; Maps; Mass Spectrum Analysis; Measures; Memory Disorders; Mentors; Mentorship; Methodology; Methods; Methylation; Minority; Modification; Molecular; Molecular Analysis; Monitor; Nerve Degeneration; Neurology; Neuronal Dysfunction; Neurons; Neuropsychology; Neurosciences; Organelles; Pathologic; Pathway interactions; Pharmacology; Phase; Play; Population; Positron-Emission Tomography; Proteome; Recording of previous events; Records; Research; Research Personnel; Research Project Grants; Research Support; Resources; Rest; Role; Serum; Signal Transduction; Site; Specimen; Synapses; Testing; Therapeutic; Tracer; Training; Translating; Translations; United States National Institutes of Health; Vocational Guidance; Whole Blood; Work; base; bench to bedside; brain tissue; career; career development; clinical care; cohort; data management; education research; epigenomics; ethnic diversity; family burden; graduate student; human subject; human tissue; induced pluripotent stem cell; kinase inhibitor; member; neuropathology; novel; outreach; programs; recruit; repaired; research and development; research study; sample collection; statistics; success; therapeutic development; transcriptomics

PROJECT SUMMARY: OVERALL YALE ADRC The Yale Alzheimer’s Disease Research Center (ADRC) seeks to advance our understanding of Alzheimer’s disease at a cell biological level with the eventual goal of translating laboratory discoveries into novel effective clinical therapies. Seven Cores (Administrative, Clinical, Data, Biomarker, Neuropathology, Imaging and Outreach) and a Research Education Component will work together to achieve this goal. Our unifying theme is a focus on the cell biology of specific neurons, and its disruption in AD, whether measured by genome/proteome-wide methods in Biofluids, imaged diagnostically, manifested clinically in behavioral attributes, detected pathologically in brain tissue at autopsy or observed in cultures of induced pluripotent stem cells. The participation of the seven Cores will accelerate and optimize the ability of individual Research Projects both within and beyond the Yale ADRC to ask and answer specific pathophysiological questions and to translate knowledge to therapies. The breadth of the Core support for particular projects will allow assessments across the heterogeneity of Alzheimer’s disease. The Yale ADRC expects to extend its track record of facilitating Research Projects focused on specific neuronal organelles and specific neuronal subtypes perturbed in disease while making use of human tissue analysis and human subject imaging to evaluate mechanistic hypotheses. The Biomarker Core will develop novel, sensitive and high-throughput mass spectrometry assays and genomic methylation profiles to monitor disease mechanisms. The Imaging Core will develop, integrate and apply novel PET tracers and functional MRI connectivity maps to subjects of the Clinical Core and multiple separately supported Research Projects. A key emphasis will be the translational development of research findings into therapeutic benefit. To support the future strength of Alzheimer’s research, the Yale ADRC will strive to advance the careers of Young Investigators through mentorship from a distinguished Internal Advisory Committee, and through Development Project awards coupled with an extensive educational program developed by the Research Education Component. In addition to collecting clinical data and biospecimens of brain, CSF, DNA, serum, blood cells and iPSCs for analysis by members of the Yale ADRC research team, the Yale ADRC will support other NIH- funded research studies on related topics and contribute materials to national NIA-sponsored research networks. The Outreach Core will connect with the community to provide greater knowledge regarding Alzheimer’s disease and related dementia.

项目概要：耶鲁ADRC总体 耶鲁大学阿尔茨海默病研究中心（ADRC）旨在促进我们对阿尔茨海默病的理解。 阿尔茨海默病在细胞生物学水平上的最终目标是将实验室发现转化为 新的有效的临床疗法。七大核心（管理、临床、数据、生物标志物、神经病理学、 成像和推广）和研究教育组成部分将共同努力，以实现这一目标。我们 统一的主题是关注特定神经元的细胞生物学，以及其在AD中的破坏，无论是通过 生物流体中的全基因组/蛋白质组方法，诊断成像，临床表现为行为 属性，尸检时在脑组织中病理学检测到或在诱导多能干细胞培养物中观察到 细胞七个核心的参与将加速和优化个人研究的能力 项目内外耶鲁ADRC问和回答具体的病理生理学问题， 将知识转化为治疗方法核心小组对特定项目的支持范围将使 评估阿尔茨海默病的异质性。 耶鲁ADRC希望扩大其促进研究项目的记录，重点是具体的 利用人体组织时，疾病中神经元细胞器和特定神经元亚型受到干扰 分析和人类受试者成像来评估机械假说。生物标志物核心将开发 新的、灵敏的和高通量的质谱分析和基因组甲基化谱， 疾病机制。成像核心将开发，集成和应用新型PET示踪剂和功能 MRI连接映射到临床核心和多个单独支持的研究项目的受试者。一 重点是将研究成果转化为治疗效益。支持 作为阿尔茨海默氏症研究的未来力量，耶鲁ADRC将努力推进Young的职业生涯。 调查人员通过杰出的内部咨询委员会的指导，并通过发展 项目奖励加上研究教育开发的广泛的教育计划 成分除了收集临床数据和脑、CSF、DNA、血清、血细胞的生物标本外， 和iPSC的分析耶鲁ADRC研究小组的成员，耶鲁ADRC将支持其他NIH- 资助相关主题的研究，并为国家NIA赞助的研究提供材料 网络.外展核心将与社区联系，以提供更多的知识， 阿尔茨海默病和相关的痴呆症。