Imaging Core

核心B将继续发挥它在我们目前的PPG中的作用，同时引入两个 用于小鼠胚胎动脉形成表型和通透性评估的新型CT成像组件 成年小鼠后肢缺血模型的建立。这三个项目都广泛使用了多普勒血流速度系统。 用于血流测量和用于动脉形成表型的高分辨率MicroCT成像， 分子、细胞和亚细胞器研究。对于胚胎表型，核心将进行主要的 所需的成像程序所需的服务，如插管和整体染色。《核心》 将执行高分辨率MicroCT图像采集、重建和分析。这些标准化的 这些努力将产生最佳的图像采集和处理、减少可变性和最大限度地提高数据可靠性， 同时促进思想从长凳到老鼠，最终到人类的转化。核心B程序 将由两名研究专家在庄振武博士的指导下进行。

Core B will continue to serve the role it plays in our present PPG, while introducing two novel CT imaging components for phenotyping embryonic arteriogenesis in mice and assessing permeability in the setting of hindlimb ischemia in adult mice. All three projects extensively utilize Doppler flow velocity system for blood flow measurements and high-resolution microCT imaging for arteriogenesis phenotyping, with molecular, cellular and sub-organelle studies. For embryonic phenotyping, the Core will perform primary services necessary for the desired imaging procedures such as catheterization and en bloc staining. The Core will execute high-resolution microCT image acquisition, reconstruction, and analysis. These standardized efforts will result in optimal image acquisition and processing, reduce variability and maximize data reliability, while facilitating the translation of ideas from the bench to mice, and ultimately to humans. Core B procedures will be performed by two research specialists under the direction of Dr. Zhenwu Zhuang.