Decision Support for Multigene Panel Testing and Family Risk Communication among Racially/Ethnically Diverse Young Breast Cancer Survivors
多基因面板测试和不同种族/民族的年轻乳腺癌幸存者之间的家庭风险沟通的决策支持
基本信息
- 批准号:10434656
- 负责人:
- 金额:$ 15.45万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-07-01 至 2026-06-30
- 项目状态:未结题
- 来源:
- 关键词:Active LearningAddressAdvisory CommitteesAgeAreaAsianAttitudeBRCA1 geneBRCA2 geneBehaviorBehavior TherapyBehavioralBeliefBiologicalBlack raceBloodBreast Cancer PatientBreast Cancer PreventionBreast Cancer survivorCancer ControlCancer SurvivorshipCancer-Predisposing GeneCaringClinicalCommunicationConflict (Psychology)Cross-Sectional StudiesCultural DiversityDataDecision AidDecision MakingDiagnosisEducational workshopEthicsEthnic groupExposure toFailureFamilyFamily history ofFamily memberFeasibility StudiesFeedbackFloridaFrequenciesFundingGenesGeneticGenetic ResearchGenetic RiskGenomic medicineGenomicsGoalsHealth Disparities ResearchHereditary Breast and Ovarian Cancer SyndromeHispanicIndividualInheritedInterventionIntervention StudiesInterviewK-Series Research Career ProgramsKnowledgeLatinaLeadershipMalignant NeoplasmsMalignant neoplasm of ovaryMeasuresMentored Research Scientist Development AwardMethodologyMethodsMinorityMinority WomenNational Cancer InstituteNational Comprehensive Cancer NetworkNot Hispanic or LatinoOncogenesOncologyOnline SystemsPALB2 geneParticipantPathogenicityPatient EducationPatientsPenetrancePopulationPopulation InterventionPredispositionPreventive serviceProductivityPublic HealthRaceRandomizedRandomized Controlled TrialsRecording of previous eventsReduce health disparitiesRelative RisksResearchResearch InstituteResearch PersonnelResearch Project GrantsRiskRisk ReductionScienceScreening for cancerSocioeconomic StatusTest ResultTestingTimeTrainingUnderserved PopulationUnited States National Institutes of HealthVariantWomanWritingbasebiobehaviorcancer geneticscancer health disparitycancer riskcareerclinical applicationethnic diversityethnic minorityexperiencegenetic panel testgenetic risk assessmentgenetic testinghealth disparitymalignant breast neoplasmprimary outcomepsychosocialracial and ethnicracial and ethnic disparitiesracial minorityrecruitsecondary outcomeskillsusabilityuser centered designvariant of unknown significanceyoung woman
项目摘要
Project Summary/Abstract:
The introduction of multi-gene panel testing for hereditary breast and ovarian cancer (HBOC) syndrome has
rapidly changed the clinical approach to genetic testing for patients and their families. Young breast cancer
survivors (YBCS), diagnosed at age ≤50 years old, may have inherited a pathogenic/likely pathogenic (P/LP)
variant in a breast cancer susceptibility gene, e.g., BRCA1, BRCA2, PALB2, etc. Recent studies have found
suboptimal rates of genetic testing among young breast cancer patients with less than 50% completion rates for
hereditary breast and ovarian cancer (HBOC) syndrome. Racial and ethnic disparities in genetic testing
completion and results have been well documented. My long-term career goal is to become a leading
independent investigator in breast cancer prevention and control, focusing on cancer genetics/genomics, risk
communication, biobehavioral oncology, and reduction of cancer health disparities among racial/ethnic minority
women. The specific aims are: In Aim 1, we propose to identify factors associated with completion of HBOC
multigene panel testing, cancer risk-reducing behaviors, and family risk communication among racially/ethnically
diverse young breast cancer survivors (YBCS) (N=300) within a sequential explanatory mixed-methods study.
In addition, we will conduct qualitative interviews with (N=40) YBCS who completed genetic testing and those
who have not completed genetic testing to explore knowledge, attitudes, beliefs about genetic testing, and to
identify barriers and facilitators to the communication of genetic risk to their at-risk relatives. We will illuminate
quantitative findings with qualitative data collected. In Aim 2, we will apply user-centered design to modify the
existing genetic testing module within the RealRisks decision aid to meet the needs of YBCS and to add family
risk communication content and conduct participatory workshops and usability testing (N=20). Lastly, in Aim 3,
we will conduct a pilot randomized controlled trial of standard patient education alone or in combination with the
modified RealRisks decision aid among racially/ethnically diverse YBCS. This career development award will
provide me with protected time and the opportunity to pursue my training goals in several targeted areas: (1):
Acquire and apply advanced statistical analytics for conducting mixed methodology and intervention research;
(2) increase knowledge and skills in biobehavioral oncology, cancer survivorship, clinical application of
genetic/genomic medicine, risk communication in families, cascade genetic testing, adapting web-based
decision support interventions for underserved populations, and breast cancer health disparities; (3) gain didactic
and experiential learning in the conduct of randomized controlled trials; and (4) develop leadership skills in the
ethical conduct of scientific research, grant writing, increasing scholarly productivity, and management skills for
scientific independence. In summary, this Mentored Research Scientist Development Award to Promote
Diversity will provide me with invaluable experiences to successfully transition into a scientific independence,
ultimately reducing health disparities.
项目总结/文摘:
项目成果
期刊论文数量(0)
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科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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{{ truncateString('Tarsha Jones', 18)}}的其他基金
Decision Support for Multigene Panel Testing and Family Risk Communication among Racially/Ethnically Diverse Young Breast Cancer Survivors
多基因面板测试和不同种族/民族的年轻乳腺癌幸存者之间的家庭风险沟通的决策支持
- 批准号:
10657728 - 财政年份:2021
- 资助金额:
$ 15.45万 - 项目类别:
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