High potency food grade growth factor mimics for low cost cultivated meat manufacture

栽培肉类有望通过提供比动物产品更符合道德、更绿色的替代品，同时保持相同的味道和质地，从而给食品行业带来革命性的变化。然而，这些产品由于生产的技术复杂性，特别是制造过程中所用材料的高昂成本，正受到阻碍。据估计，成本需要降低99%或更多。这些成本的主要贡献者是生产中使用的蛋白质，这些蛋白质提供生物线索来刺激生长，并确保生产出正确类型的肉类细胞。除非这些蛋白质的成本能降低99%或更多，否则该行业将无法在经济上生存。MarraBio已经开发出一种全新的方法来制造当前使用的蛋白质的替代品。它的原料可以大量生产，而且成本将使培育的肉类在经济上可行。到目前为止，MarraBio已经生产出了这些产品的“研究级”版本，并有初步证据表明它们将满足该行业的需求。在该项目中，MarraBio将证明这些产品可以规模化生产，质量达到栽培肉类生产所需的监管要求。如果成功，到项目结束时，我们将能够在这个快速增长的市场上推出我们的产品。为了实现这些目标，MarraBio与过程创新中心(CPI)和Aelius Biotech合作。CPI是蛋白质制造和分析领域的领先者，将协助MarraBio改进其制造技术，以提供对产品质量和效力的严格控制。埃利乌斯生物技术公司已经开发出一种肠道模型，可以预测摄入的物质将如何影响消化系统。他们的参与将使MarraBio能够测试他们的产品在摄入后是如何处理的--这是一个关键的安全步骤--同时使Aelius能够进一步开发他们的技术，以满足这一领域的需求。由于所有参与者都在英格兰东北部，他们的合作将支持该地区快速增长的栽培肉类行业。该项目的结果将对经济地生产栽培肉类的能力产生重大影响。这将提供一种高质量、强效的产品，简化并降低养殖肉类生产的成本。

Cultivated meat promises to revolutionize the food industry by providing a more ethical and greener alternative to animal products, whilst retaining the same taste and texture. However, these products are being held back by the technical complexity of production and, in particular, the high cost of materials used in their manufacture. It is estimated that costs need to be reduced by 99% or more.A major contributor to these costs are the proteins used in production which supply biological cues to stimulate growth and ensure that the right type of meat cells are produced. Unless the cost of these proteins can be reduced by 99% or more, the sector will not be economically viable.MarraBio has have developed a radically new way to make alternatives to the proteins currently used. Its materials can be made in very large quantities, and at a cost which will make cultivated meat economically viable. So far, MarraBio has produced "research grade" versions of the products and have preliminary evidence that they will meet the needs of the sector. In the project, MarraBio will demonstrate that the products can be produced at scale and at a quality where they will meet the regulatory requirements needed for their use in cultivated meat production. If successful, by the end of the project we will be in a position to launch our products on this rapidly growing market.To achieve these aims MarraBio are partnering with the Centre for Process Innovation (CPI) and Aelius Biotech. CPI is a leader in protein manufacturing and analysis and will assist MarraBio in refining its manufacturing techniques to provide tight control over product quality and potency. Aelius Biotech have developed a model of the gut that predicts how ingested substances will affect the digestive system. Their involvement will allow MarraBio to test how their products are processed on ingestion - a critical safety step -- whilst allowing Aelius to further develop their technology towards the needs of this sector. With all participants based in North East England, their collaboration will support the rapidly growing cultivated meat sector in the region.The outcomes of the project will have a significant impact on the ability to economically produce cultivated meat. This will provide a high quality, potent product that simplifies and reduces the cost of cultivated meat manufacture.