Molecular Biology and Genetics: Signaling, Epigenetics and Genome Maintenance

我们社会的生物医学劳动力研究需求在规模和多样性上都有所增加。我们有 帮助培养下一代科学家的责任，不仅要满足学术界的研究需求， 产业，而是培养鼓舞人心的大学科学教师，有效的研究管理人员，科学政策制定者， 医学作家和科学编辑，商业和金融分析师，科学顾问，大生物科学数据 管理人员以及其他未来必不可少的生物医学研究工作。因此，我们的毕业生将需要 具备严谨的批判性思维能力，发展跨学科的观点，学会分析 复杂的数据集，开发复杂的研究方法，利用复杂的设备，同时保持 精神灵活性，以跟上生物医学研究探索和应用的快节奏。整体 这个博士预科课程的目标是在广泛的领域提供特殊的跨学科培训机会 分子和细胞生物学和遗传学，特别关注细胞信号，表观遗传学和基因组 上维护这个跨学科项目的成员包括来自刘易斯卡茨医学院的教师 （LKSOM），他们是癌症生物学和遗传学（CBGN）以及分子和细胞生物学的导师。 浓度集群。虽然有许多传统的方案，提供培训，在每一个 这三个领域，该计划将为学生提供所需的工具和观点，考虑如何 这三个与疾病高度相关的领域相互交叉。 选择这一培训建议的重点主要是为了反映这些领域的多个领导人的存在。 CBGN和MCBS集群中的字段。该提案将支持实验室的研究培训机会- 36名助理教授、副教授和正教授。该计划的导师带来了多学科的力量 在分子和细胞生物学，生物化学，生物物理学，遗传学和表观遗传学，使用状态的程序 在共聚焦和TIRF显微镜、质谱蛋白质组学、结构生物学、分子模型、 eling，生物信息学，高通量筛选，基因组学和表观基因组学，使用各种动物和细胞 模型系统和人体样本。导师在这个计划有一个悠久的传统，在培训双方的研究生 学生和博士后研究员具有很高的学术标准，并将接受额外的培训，在现代， 以证据为基础的指导实践。这一计划将进一步提供更广泛的了解疾病 机制，并将在学员中发展与临床挑战相关的深入了解， 他们的研究兴趣领域。毕业后，我们相信，这一独特的跨学科培训经验- Eence将使我们的学生不仅在学术界，工业界，科学学院的未来职位具有很强的竞争力 教育、研究管理、科学政策和宣传、技术转让、科学和医疗文书 信息和科学编辑，商业和金融分析，科学咨询，大生物科学数据管理和 一系列更广泛的未来生物医学研究工作。

The biomedical workforce research needs of our society have increased in size and diversity. We have the responsibility to help train the next generation of scientists, not only to feed the research needs of academia and industry, but to train inspiring college science faculty, effective research administrators, science policy makers, medical writers and scientific editors, business and financial analysts, science consultants, big bioscience data managers as well as other future essential biomedical research jobs. Thus, our graduates will need to be equipped with abilities for rigorous critical thinking, develop an interdisciplinary perspective, learn to analyze complex sets of data, develop complex research approaches utilizing complex equipment while maintaining the mental flexibility to keep up with the fast pace of biomedical research exploration and application. The overall goal of this predoctoral program is to offer exceptional interdisciplinary training opportunities in the broad area of Molecular and Cellular Biology and Genetics with special interest in cell signaling, epigenetics and genome maintenance. Members of this interdisciplinary program include faculty from the Lewis Katz School of Medicine (LKSOM), who are mentors in the Cancer Biology and Genetics (CBGN) and the Molecular and Cellular Biosci- ence (MCBS) concentration clusters. While there are many traditional programs that offer training in each of these three areas, this program will provide students with the tools and perspectives needed to consider how these three highly disease-relevant fields intersect. The focus for this training proposal was chosen primarily to reflect the presence of multiple leaders in these fields in the CBGN and MCBS clusters. This proposal will support research training opportunities in the labora- tories of 36 Assistant, Associate and full Professors. Mentors in this program bring strength in multidisciplinary programs in molecular and cellular biology, biochemistry, biophysics, genetics and epigenetics, using state of the art approaches in confocal and TIRF microscopy, mass spec proteomics, structural biology, molecular mod- eling, bioinformatics, high throughput screens, genomics, and epigenomics using a variety of animal and cellular model systems and human samples. Mentors in this program have a long tradition in the training of both graduate students and postdoctoral fellows with very high academic standards and will receive additional training in mod- ern evidence-based mentoring practices. This program will further provide a broader understanding of disease mechanisms and will develop in the trainees an in-depth understanding of the clinical challenges associated with their research interest area. Upon graduating, we are confident that this unique interdisciplinary training experi- ence will make our students not only highly competitive for future positions in academia, industry, science college education, research administration, science policy and advocacy, technology transfer, science and medical writ- ing and scientific editing, business and financial analysis, science consulting, big bioscience data managing and a broader array of future biomedical research jobs.