Molecular Biology and Genetics: Signaling, Epigenetics and Genome Maintenance

分子生物学和遗传学：信号传导、表观遗传学和基因组维护

• 批准号: 10615210
• 负责人: Xavier Grana
• 金额: $ 25.51万
• 依托单位: TEMPLE UNIV OF THE COMMONWEALTH
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10615210
• 关键词: Epigenetic Process; Genome; Maintenance; Molecular Biology; Molecular Genetics; Signal Transduction

The biomedical workforce research needs of our society have increased in size and diversity. We have the responsibility to help train the next generation of scientists, not only to feed the research needs of academia and industry, but to train inspiring college science faculty, effective research administrators, science policy makers, medical writers and scientific editors, business and financial analysts, science consultants, big bioscience data managers as well as other future essential biomedical research jobs. Thus, our graduates will need to be equipped with abilities for rigorous critical thinking, develop an interdisciplinary perspective, learn to analyze complex sets of data, develop complex research approaches utilizing complex equipment while maintaining the mental flexibility to keep up with the fast pace of biomedical research exploration and application. The overall goal of this predoctoral program is to offer exceptional interdisciplinary training opportunities in the broad area of Molecular and Cellular Biology and Genetics with special interest in cell signaling, epigenetics and genome maintenance. Members of this interdisciplinary program include faculty from the Lewis Katz School of Medicine (LKSOM), who are mentors in the Cancer Biology and Genetics (CBGN) and the Molecular and Cellular Biosci- ence (MCBS) concentration clusters. While there are many traditional programs that offer training in each of these three areas, this program will provide students with the tools and perspectives needed to consider how these three highly disease-relevant fields intersect. The focus for this training proposal was chosen primarily to reflect the presence of multiple leaders in these fields in the CBGN and MCBS clusters. This proposal will support research training opportunities in the labora- tories of 36 Assistant, Associate and full Professors. Mentors in this program bring strength in multidisciplinary programs in molecular and cellular biology, biochemistry, biophysics, genetics and epigenetics, using state of the art approaches in confocal and TIRF microscopy, mass spec proteomics, structural biology, molecular mod- eling, bioinformatics, high throughput screens, genomics, and epigenomics using a variety of animal and cellular model systems and human samples. Mentors in this program have a long tradition in the training of both graduate students and postdoctoral fellows with very high academic standards and will receive additional training in mod- ern evidence-based mentoring practices. This program will further provide a broader understanding of disease mechanisms and will develop in the trainees an in-depth understanding of the clinical challenges associated with their research interest area. Upon graduating, we are confident that this unique interdisciplinary training experi- ence will make our students not only highly competitive for future positions in academia, industry, science college education, research administration, science policy and advocacy, technology transfer, science and medical writ- ing and scientific editing, business and financial analysis, science consulting, big bioscience data managing and a broader array of future biomedical research jobs.

我们社会对生物医学劳动力研究的需求在规模和多样性上都有所增加。我们有 帮助培养下一代科学家的责任，不仅是为了满足学术界和 但要培养鼓舞人心的大学理科教师、有效的研究管理人员、科学政策制定者， 医学作家和科学编辑、商业和金融分析师、科学顾问、大型生物科学数据 管理人员以及其他未来重要的生物医学研究工作。因此，我们的毕业生将需要 具备严谨的批判性思维能力，发展跨学科视角，学会分析 复杂的数据集，利用复杂的设备开发复杂的研究方法，同时维护 心理灵活性跟上了生物医学研究、探索和应用的快节奏。整体而言 这一博士前项目的目标是在广阔的领域内提供卓越的跨学科培训机会。 分子和细胞生物学与遗传学，对细胞信号、表观遗传学和基因组特别感兴趣 维修。这个跨学科项目的成员包括刘易斯·卡茨医学院的教职员工。 (LKSOM)，他们是癌症生物学和遗传学(CBGN)以及分子和细胞生物学的导师- ENS(MCBS)浓度集群。虽然有许多传统的项目在每一个项目中提供培训 这三个领域，本课程将为学生提供所需的工具和观点，以考虑如何 这三个与疾病高度相关的领域相交。 本培训计划的重点主要是反映多个领导者在这些 CBGN和MCBS群集中的字段。该提案将支持实验室的研究培训机会- 托利斯党36名助理教授、副教授和正教授。该项目的导师带来了多学科的力量 分子和细胞生物学、生物化学、生物物理学、遗传学和表观遗传学的课程，使用状态 ART在共聚焦显微镜和TIRF显微镜、质谱学蛋白质组学、结构生物学、分子模型等方面的研究进展。 Eling、生物信息学、高通量筛选、基因组学和使用各种动物和细胞的表观基因组学 模型系统和人体样本。该项目的导师在培养两位毕业生方面有着悠久的传统 学生和博士后具有很高的学术水平，并将接受额外的培训，在MOD- ERN循证指导实践。该计划将进一步提供对疾病的更广泛的了解 机制，并将在受训人员中深入了解与以下相关的临床挑战 他们的研究兴趣领域。毕业后，我们相信这一独特的跨学科培训经验- ENCE将使我们的学生不仅在未来的学术界、工业界、理工学院的职位上具有很强的竞争力 教育、研究管理、科学政策和宣传、技术转让、科学和医学文书-- ING和科学编辑、商业和金融分析、科学咨询、大生物科学数据管理和 更广泛的未来生物医学研究工作。

项目成果

Eosinophilic esophagitis-associated epithelial remodeling may limit esophageal carcinogenesis.

• DOI: 10.3389/falgy.2023.1086032
• 发表时间: 2023
• 期刊: FRONTIERS IN ALLERGY
• 作者: Fuller, Annie D.;Karami, Adam L.;Kabir, Mohammad Faujul;Klochkova, Alena;Jackson, Jazmyne L.;Mu, Anbin;Tan, Yinfei;Klein-Szanto, Andres J.;Whelan, Kelly A.
• 通讯作者: Whelan, Kelly A.

A role for age-associated alterations in esophageal epithelium in eosinophilic esophagitis-associated fibrosis.

• DOI: 10.3389/falgy.2022.983412
• 发表时间: 2022
• 期刊: FRONTIERS IN ALLERGY
• 作者: Klochkova, Alena;Fuller, Annie D.;Miller, Riley;Karami, Adam L.;Panchani, Surali R.;Natarajan, Shruthi;Mu, Anbin;Jackson, Jazmyne L.;Klein-Szanto, Andres J.;Muir, Amanda B.;Whelan, Kelly A.
• 通讯作者: Whelan, Kelly A.

Mutant C. elegans p53 Together with Gain-of-Function GLP-1/Notch Decreases UVC-Damage-Induced Germline Cell Death but Increases PARP Inhibitor-Induced Germline Cell Death.

• DOI: 10.3390/cancers14194929
• 发表时间: 2022-10-08
• 期刊: Cancers
• 影响因子: 5.2