Transforming the measurement of modified proteins using mass spectrometry data and advanced software

使用质谱数据和先进软件改变修饰蛋白质的测量

• 批准号: 10073842
• 金额: $ 2.03万
• 依托单位: TURBINIA LTD
• 依托单位国家: 英国
• 项目类别: Collaborative R&D
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=10073842
• 关键词: Transforming; measurement; modified; proteins; using

**Summary**This is a project part funded by an InnovateUK grant, running over 9 months. The goal is to improve the ability of Turbinia's software to analyse modified forms of proteins. This is a problem Turbinia have been unable to solve with software alone, so we will be working with the mass spectrometry experts at the Royce Institute.**What Turbinia does, how it helps our customers**Turbinia is developing a new software platform to help customers in the pharmaceutical and diagnostic industries to develop more and better drugs and tests. The drug discovery process can be thought of like a sales process. You find leads, filter out the poor ones until you only have those with true potential, then work on those until you close the sale. Turbinia's software helps find leads for possible new drugs and diagnostics where it has traditionally been hard to find them and helps ensure that the leads passed on to the next stage are likely to yield results. Our "lead-finding" market is called proteomics.**Need or challenge addressed by your innovation**In 2021 the global pharmaceutical market spent $298b on R&D, and yet the FDA only approved 50 new drugs - compared to over 150 per year in the 1970s. We believe that this project will enable us to deliver more candidate biomarkers to the drug discovery process.**How the Royce Institute will help**Firstly, with their expertise in this highly specialised field. Secondly by providing test samples (and the data from them) specifically designed to enable Turbinia to understand and solve the analysis problems posed by modified forms of proteins. Finally, by providing comparative analyses run using the current standard techniques and a blinded trial to measure our progress.**Outcomes of the project for Turbinia**A first version of the software ready to demonstrate to customers. Honed from iterative loops of prototype development and testing with the Royce.**Routes to market**Software sales will be world-wide, direct and via multinational distributors - a model the team is very familiar with in this space.**Wider impacts**The product will help customers develop new drugs. If this project enables Turbinia's UK customers to bring just one new drug to market, the value in sales to them could be measured in billions, while saving lives and easing the pressure on the NHS.

**摘要**这是一个由InnovateUK基金资助的项目部分，持续时间超过9个月。其目标是提高Turbinia软件分析蛋白质修饰形式的能力。这是Turbinia仅靠软件无法解决的问题，因此我们将与罗伊斯研究所的质谱学专家合作。**Turbinia做什么，它如何帮助我们的客户**Turbinia正在开发一个新的软件平台，帮助制药和诊断行业的客户开发更多更好的药物和测试。药物发现过程可以被认为是一个销售过程。你找到线索，过滤掉糟糕的线索，直到你只有真正有潜力的线索，然后继续努力，直到你完成销售。Turbinia的软件有助于为可能的新药和诊断找到线索，而这些线索传统上很难找到，并有助于确保传递到下一阶段的线索可能会产生结果。我们的“领先发现”市场被称为蛋白质组学。**您的创新解决了**需求或挑战**2021年，全球药品市场在研发上花费了2980亿美元，但FDA只批准了50种新药--而在20世纪70年代，每年超过150种。我们相信，这个项目将使我们能够为药物发现过程提供更多的候选生物标记物。**罗伊斯研究所将如何帮助**首先，凭借他们在这一高度专业化领域的专业知识。其次，通过提供专门设计的测试样本(以及测试样本中的数据)，使Turbinia能够理解和解决蛋白质修饰形式带来的分析问题。最后，通过提供使用当前标准技术和盲法试验运行的比较分析来衡量我们的进展。**Turbinia项目的结果**该软件的第一个版本准备向客户演示。在与罗伊斯的原型开发和测试的迭代循环中磨练。**进入市场的路线**软件销售将是全球范围的、直接的，并通过跨国分销商--该团队在该领域非常熟悉的模式。**更广泛的影响**产品将帮助客户开发新药。如果该项目使Turbinia的英国客户能够只将一种新药推向市场，那么向他们销售的价值可以用数十亿来衡量，同时拯救生命并缓解NHS的压力。